INT55698

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Context Info
Confidence 0.44
First Reported 1994
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 8.98
Pain Relevance 4.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
T cells 4
nerve 2
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 291 100.00 Very High Very High Very High
Inflammation 176 100.00 Very High Very High Very High
methotrexate 148 100.00 Very High Very High Very High
Pain 13 100.00 Very High Very High Very High
Etanercept 196 99.44 Very High Very High Very High
Bioavailability 2 99.00 Very High Very High Very High
withdrawal 3 98.80 Very High Very High Very High
Adalimumab 37 98.60 Very High Very High Very High
cytokine 141 97.48 Very High Very High Very High
spinal inflammation 9 96.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 292 100.00 Very High Very High Very High
INFLAMMATION 182 100.00 Very High Very High Very High
Asthma 62 100.00 Very High Very High Very High
Necrosis 36 100.00 Very High Very High Very High
Cancer 32 100.00 Very High Very High Very High
Pain 8 100.00 Very High Very High Very High
Spondylarthropathies 5 98.20 Very High Very High Very High
Low Back Pain 11 96.88 Very High Very High Very High
Disease 138 96.40 Very High Very High Very High
Seronegative Spondarthritis 89 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
has been postulated to play an important role in the pathogenesis of asthma, the role of TNF-?
Regulation (role) of TNF Binding (role) of associated with asthma
1) Confidence 0.44 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 1.44 Pain Relevance 0.35
[Anti-TNF-alpha treatment--an effective complement in spondyloarthropathy].
Regulation (effective) of TNF-alpha Binding (complement) of associated with methotrexate
2) Confidence 0.44 Published 2002 Journal Lakartidningen Section Title Doc Link 12572316 Disease Relevance 0.59 Pain Relevance 0.34
Patients treated with combination of MTX and TNF-?
Regulation (treated) of TNF Binding (combination) of associated with methotrexate
3) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0.34 Pain Relevance 0.31
converting enzyme inhibitor.16,17 In addition, involvement of TNF-?
Regulation (converting) of TNF Binding (involvement) of
4) Confidence 0.44 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 1.18 Pain Relevance 0.36
Infliximab (Remicade®; Centocor, Inc., Malvern, PA, USA), etanercept (Enbrel®; Immunex Corp, Seattle, WA, USA), and adalimumab (Humira™; Abbott Laboratories, Abbott Park, IL, USA) are designed to modulate the inflammatory cascade of RA by binding TNF, thereby decreasing its bioavailability.
Regulation (modulate) of TNF Binding (binding) of associated with inflammation, infliximab, rheumatoid arthritis, adalimumab, etanercept and bioavailability
5) Confidence 0.38 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC2833457 Disease Relevance 0.95 Pain Relevance 0.80
Urinary concentrations of tumor necrosis factor, prostaglandins E2, D2 and F2 alpha, and thromboxane B2 were not different among either patient groups or controls.
Neg (not) Regulation (different) of tumor necrosis factor Binding (concentrations) of associated with necrosis and cancer
6) Confidence 0.34 Published 1994 Journal J. Urol. Section Abstract Doc Link 8015071 Disease Relevance 1.38 Pain Relevance 0.42
We conclude that neutralization of endoneurial TNF attenuates pain related behavior but has no effect on nerve regeneration.
Neg (no) Regulation (effect) of TNF Binding (neutralization) of in nerve associated with pain
7) Confidence 0.31 Published 2000 Journal Brain Res. Section Abstract Doc Link 10825476 Disease Relevance 1.06 Pain Relevance 1.07
on CD16 expression, human PBMC were cultured in either plain media or media supplemented with TNF?
Regulation (cultured) of TNF Binding (supplemented) of
8) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0 Pain Relevance 0
To ascertain the possible influence of this functional SNP on the association between antimalarial treatment and decreased TNF?
Spec (possible) Regulation (influence) of TNF Binding (association) of
9) Confidence 0.30 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526590 Disease Relevance 0.24 Pain Relevance 0.09
there was a marked increase in both TRADD and RIP recovery confirming the formation of a TNF?
Regulation (confirming) of TNF Binding (formation) of
10) Confidence 0.17 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0
After binding to TNF?
Regulation (After) of TNF Binding (binding) of
11) Confidence 0.08 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721350 Disease Relevance 0.70 Pain Relevance 0.61
does not influence the outcome after TNF-?
Neg (not) Regulation (influence) of TNF Binding (outcome) of
12) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.77 Pain Relevance 0.04
in murine T cells,25 using a combination of IL-2, IL-6, and TNF-?
Regulation (using) of TNF Binding (combination) of in T cells
13) Confidence 0.07 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.10 Pain Relevance 0.27
Although the percentage of IL-17-producing CD4 T cells coexpressing TNF?
Regulation (Although) of TNF Binding (percentage) of in T cells
14) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.22 Pain Relevance 0.07

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