INT55710

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Context Info
Confidence 0.41
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 1.45
Pain Relevance 4.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Phax) RNA binding (Phax) nucleus (Phax)
cytoplasm (Phax)
Anatomy Link Frequency
neurons 2
Phax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 139 100.00 Very High Very High Very High
intrathecal 30 99.98 Very High Very High Very High
Neuropeptide 1 99.24 Very High Very High Very High
Inflammation 26 98.32 Very High Very High Very High
dorsal root ganglion 30 97.88 Very High Very High Very High
c fibre 140 92.60 High High
antagonist 14 91.80 High High
analgesia 37 91.36 High High
hyperexcitability 2 89.76 High High
hypoalgesia 8 88.16 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 26 98.32 Very High Very High Very High
Ganglion Cysts 36 97.88 Very High Very High Very High
Hypersensitivity 11 89.48 High High
Hypoalagesia 8 88.16 High High
Nociception 72 75.00 Quite High
Pain 49 71.96 Quite High
Depression 6 49.76 Quite Low
Neuropathic Pain 9 41.36 Quite Low
Nervous System Injury 3 37.28 Quite Low
Body Weight 9 12.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both expressed bacterial fusion proteins and cytoplasmic fractions from COS cells transfected with an expression vector encoding RTX-42 showed [3H]resiniferatoxin binding activity (IC50 approximately 10 nM).
Positive_regulation (transfected) of Gene_expression (expression) of RTX-42
1) Confidence 0.41 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8015392 Disease Relevance 0.06 Pain Relevance 0.27
Thus, RTX produced marked and prolonged impairment of capsaicin-sensitive afferents and upregulation of the inhibitory neuropeptides GMAP and galanin in DRG neurons, which may underlie the prolonged effect of RTX.
Positive_regulation (upregulation) of Gene_expression (produced) of RTX in neurons associated with dorsal root ganglion, qutenza and neuropeptide
2) Confidence 0.16 Published 1997 Journal Brain Res. Section Abstract Doc Link 9106440 Disease Relevance 0.53 Pain Relevance 0.89
behavioral responses after RTX may indicate that the A?
Positive_regulation (after) of Gene_expression (responses) of RTX
3) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.05 Pain Relevance 0.61
and C stimuli on day 18; after 50 ng RTX, rats were generally unresponsive to the 5.12 W/mm2 A?
Positive_regulation (generally) of Gene_expression (unresponsive) of RTX
4) Confidence 0.14 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0 Pain Relevance 0.51
and C stimuli on day 18; after 50 ng RTX, rats were generally unresponsive to the 5.12 W/mm2 A?
Positive_regulation (stimuli) of Gene_expression (unresponsive) of RTX
5) Confidence 0.14 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0 Pain Relevance 0.52
Intrathecal administration of RTX prevented the reduction in PWL caused by inflammation (control, 9.5±0.9 s (n?
Positive_regulation (administration) of Gene_expression (administration) of RTX associated with inflammation and intrathecal
6) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.81 Pain Relevance 0.65
Second, very high concentrations of CAP but not RTX (>10 ?
Positive_regulation (concentrations) of Gene_expression (>10) of RTX associated with qutenza
7) Confidence 0.04 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1481593 Disease Relevance 0 Pain Relevance 0.70

General Comments

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