INT55736

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Context Info
Confidence 0.68
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.78
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP2) extracellular space (MMP2) extracellular region (MMP2)
proteinaceous extracellular matrix (MMP2) plasma membrane (MMP2) nucleus (MMP2)
Anatomy Link Frequency
bladder 1
extracellular matrix 1
MMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 262 100.00 Very High Very High Very High
cytokine 9 99.00 Very High Very High Very High
Chronic pancreatitis 6 98.60 Very High Very High Very High
COX-2 inhibitor 2 92.16 High High
Inflammation 14 81.60 Quite High
fibrosis 1 80.24 Quite High
cINOD 4 75.00 Quite High
imagery 28 68.96 Quite High
Catecholamine 18 54.48 Quite High
Hippocampus 2 25.80 Quite Low
Disease Link Frequency Relevance Heat
Renal Cancer 8 99.56 Very High Very High Very High
Cancer 246 98.92 Very High Very High Very High
Aggression 4 98.64 Very High Very High Very High
Pancreatitis 6 98.60 Very High Very High Very High
Lung Cancer 4 98.48 Very High Very High Very High
Bladder Cancer 61 98.36 Very High Very High Very High
Reprotox - General 1 63 94.32 High High
Paraganglioma 70 90.88 High High
Malignant Neoplastic Disease 32 86.32 High High
Pathologic Processes 4 85.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that NS398 inhibited MMP-2, not MMP-9, mRNA expression.
Transcription (expression) of MMP-2
1) Confidence 0.68 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11728453 Disease Relevance 0.41 Pain Relevance 0.30
We performed promoter activity assay to address whether NS398 might affect MMP-2 gene transcription.
Transcription (transcription) of MMP-2
2) Confidence 0.68 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11728453 Disease Relevance 0.44 Pain Relevance 0.33
Kanayama et al. [33] found an elevated mRNA expression of MMP2 and MMP9 in tissue of muscular invasive bladder tumours compared to non-invasive tumours.
Transcription (expression) of MMP2 in bladder associated with cancer and bladder cancer
3) Confidence 0.67 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 1.11 Pain Relevance 0.16
Kugler et al. [38] stated for renal cell carcinoma (RCC) that the balance of MMP2- and MMP9- to TIMP1- and TIMP2-mRNA expression is a prognostic factor of tumour aggressiveness.
Transcription (expression) of MMP2 associated with cancer, aggression and renal cancer
4) Confidence 0.59 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.94 Pain Relevance 0.22
This inhibition was caused by the decrease in gene expression and transcriptional activity of MMP-2[25].
Transcription (activity) of MMP-2
5) Confidence 0.30 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0 Pain Relevance 0.04
The very low proliferation index (<1%) found in the presented case and the fact that no telomerase activity, hTERT expression, topoisomerase IIa expression, or mRNA expression of MMP-2 and EMMPRIN metalloproteinases was identified show the benign nature of this lesion.
Transcription (expression) of MMP-2 associated with metalloproteinase
6) Confidence 0.29 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1976114 Disease Relevance 0.41 Pain Relevance 0.21
Although several markers such as immunohistochemical expression of the cell proliferation marker Ki-67/MIB-1, telomerase activity, hTERT expression, topoisomerase IIa expression, and mRNA expression of MMP-2 and EMMPRIN metalloproteinases have shown promising results, they need further evaluation.
Transcription (expression) of MMP-2 associated with metalloproteinase
7) Confidence 0.29 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1976114 Disease Relevance 0.93 Pain Relevance 0.18
Levels of MMP-2 and MMP-9 mRNA expression were not upregulated by cytokine stimulation (data not shown) and their protein levels were not analyzed.


Transcription (expression) of MMP-2 associated with cytokine
8) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212570 Disease Relevance 0 Pain Relevance 0.05
kDa has been reported to have a strong inhibitory effect on MMP-2 by decreasing the gene expression and transcriptional activity of MMP-2.
Transcription (activity) of MMP-2
9) Confidence 0.15 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 0.43 Pain Relevance 0.11
MMP-2 transcript levels were evaluated in these cells by qRT/PCR, and it was shown that genistein decreased MMP-2 gene expression to 24% of the level seen in control subjects.
Transcription (levels) of MMP-2
10) Confidence 0.12 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.44 Pain Relevance 0
Steady-state levels of transcripts encoding extracellular matrix proteins, MMP-2 (72 kDa collagenase IV) and TIMP-2 were enhanced in 7 out of 8 chronic pancreatitis tissue samples and showed a large degree of variation between individual patients.
Transcription (levels) of collagenase IV in extracellular matrix associated with chronic pancreatitis
11) Confidence 0.07 Published 1994 Journal Z Gastroenterol Section Abstract Doc Link 8017097 Disease Relevance 0.67 Pain Relevance 0.68

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