INT55737

Context Info Confidence 0.68 First Reported 1994 Last Reported 2011 Negated 4 Speculated 0 Reported most in Body Documents 101 Total Number 101 Disease Relevance 59.11 Pain Relevance 27.71

peptidase activity (MMP2) extracellular space (MMP2) extracellular region (MMP2) proteinaceous extracellular matrix (MMP2) plasma membrane (MMP2) nucleus (MMP2)

Anatomy Link Frequency fibroblasts 5 decidua 4 lateral 4 chondrocytes 2 brain 2 MMP2 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 2009 100.00 ischemia 201 99.98 Dismenorea 21 99.96 rheumatoid arthritis 440 99.84 cytokine 408 99.84 Chronic pancreatitis 37 99.44 Inflammation 716 99.26 IPN 4 98.76 dexamethasone 224 98.16 COX-2 inhibitor 153 97.96

Disease Link Frequency Relevance Heat Cv Unclassified Under Development 148 99.98 Dysmenorrhea 20 99.96 Herpes Simplex Virus 477 99.84 Rheumatoid Arthritis 465 99.84 Metastasis 335 99.82 Renal Cancer 85 99.82 Bladder Cancer 178 99.48 Lung Cancer 164 99.44 Pancreatitis 38 99.44 Glioblastoma 10 99.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We found that in media conditioned by decidua, following the establishment of uterine contractions, matrix metalloproteinase-2 (MMP-2) activity is increased while the protein tissue inhibitors of matrix metalloproteinase-1 (TIMP-1) level is decreased.

Positive_regulation (increased) of MMP-2 in decidua associated with metalloproteinase and dismenorea

1) Confidence 0.68 Published 2003 Journal Mol. Hum. Reprod. Section Abstract Doc Link 12771238 Disease Relevance 0.33 Pain Relevance 0.38

We found that in media conditioned by decidua, following the establishment of uterine contractions, matrix metalloproteinase-2 (MMP-2) activity is increased while the protein tissue inhibitors of matrix metalloproteinase-1 (TIMP-1) level is decreased.

Positive_regulation (increased) of matrix metalloproteinase-2 in decidua associated with metalloproteinase and dismenorea

2) Confidence 0.68 Published 2003 Journal Mol. Hum. Reprod. Section Abstract Doc Link 12771238 Disease Relevance 0.33 Pain Relevance 0.38

The notable exception compared with control and Dupuytren's tissue was the absence of MMP-14, which is known to be a membrane-type MMP required for the activation of MMP-2 (gelatinase A).

Positive_regulation (activation) of gelatinase A associated with dupuytren's disease

3) Confidence 0.67 Published 2000 Journal J Bone Joint Surg Br Section Abstract Doc Link 10963182 Disease Relevance 0.46 Pain Relevance 0.34

They found elevated concentrations of MMP2 and MMP3 in patients with advanced TCC of the bladder (pT2-T4, N+, M+) in comparison to the serum of patients with superficial tumors (Ta-T1, N0, M0).

Positive_regulation (elevated) of MMP2 in bladder associated with cancer and transitional cell carcinoma

4) Confidence 0.65 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 1.11 Pain Relevance 0.12

Both C. yanhusuo extract and its active compound berberine significantly suppressed the VEGF-induced upregulation of matrix metalloproteinase 2 (MMP2) at both mRNA and protein levels.

Positive_regulation (upregulation) of MMP2 associated with metalloproteinase

5) Confidence 0.50 Published 2009 Journal Oncol. Res. Section Abstract Doc Link 19806782 Disease Relevance 0.07 Pain Relevance 0.12

Both C. yanhusuo extract and its active compound berberine significantly suppressed the VEGF-induced upregulation of matrix metalloproteinase 2 (MMP2) at both mRNA and protein levels.

Positive_regulation (upregulation) of matrix metalloproteinase 2 associated with metalloproteinase

6) Confidence 0.50 Published 2009 Journal Oncol. Res. Section Abstract Doc Link 19806782 Disease Relevance 0.07 Pain Relevance 0.12

More recently, studies have demonstrated that differentiated thyroid cancer cell invasion in vivo is regulated through EGFR-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A (Yeh et al 2006).

Positive_regulation (activation) of gelatinase A in thyroid associated with thyroid neoplasm and metalloproteinase

7) Confidence 0.49 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.91 Pain Relevance 0.24

Two matrix metalloproteinase were upregulated (MMP2 and an MIFR1), whereas ADAM metallopeptidase domain 3A was significantly downregulated.

Positive_regulation (upregulated) of MMP2 associated with metalloproteinase

8) Confidence 0.48 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.30 Pain Relevance 0.09

MMP-2, -3, and IL-8 mRNA expression was up-regulated by the compression, and both MMP-1 and -3 protein expression and MMP-2 activity were detected.

Positive_regulation (up-regulated) of MMP-2

9) Confidence 0.48 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 17652211 Disease Relevance 1.04 Pain Relevance 0.72

Some groups have found that MMP-1, -2 and -9 are not elevated at the presentation, but that they increase during the subsequent 7 to 14 days.43 Other groups have reported no significant elevation in MMP-2, but a rapid rise and fall of MMP-9 within the first week after ACS.

Neg (no) Positive_regulation (elevation) of MMP-2 associated with acute coronary syndrome

10) Confidence 0.48 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.08 Pain Relevance 0.17

Their studies revealed further elevated MMP2, MMP3, and TIMP2 concentrations from patients after tumour resection, which might function as a predictive value for early detection of tumour recurrence [20,40].

Positive_regulation (elevated) of MMP2 associated with cancer and recurrence

11) Confidence 0.47 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 1.13 Pain Relevance 0.17

Activated MMP1, MMP3 and latent forms of MMP2 and MMP9 are regulated and inhibited by endogenous proteins known as tissue inhibitors of metalloproteinase TIMP1 and TIMP2 [17].

Positive_regulation (Activated) of MMP2 associated with metalloproteinase

12) Confidence 0.47 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.88 Pain Relevance 0.23

Induction of matrix metalloproteinase-2 and -3 activity in ovine nucleus pulposus cells grown in three-dimensional agarose gel culture by interleukin-1beta: a potential pathway of disc degeneration.

Positive_regulation (Induction) of metalloproteinase-2 in nucleus pulposus associated with intervertebral disk degeneration and metalloproteinase

13) Confidence 0.47 Published 2003 Journal Eur Spine J Section Title Doc Link 12592549 Disease Relevance 0.35 Pain Relevance 0.27

CONCLUSION: Our results indicate that the elevation of MMP-2, -9 expression may have an important role in the development of adenomyosis, probably through contributing to invasion of endometrial tissues into the myometrium and angiogenesis in adenomyotic implants.

Positive_regulation (elevation) of MMP-2 in myometrium

14) Confidence 0.46 Published 2006 Journal Gynecol. Obstet. Invest. Section Body Doc Link 16837781 Disease Relevance 0.06 Pain Relevance 0

RESULTS: Gelatin zymography revealed that not only activated MMP-2 levels but also proMMP-9 levels in SF from the knee joints of gouty arthritis were associated with the local arthritis activity scores (LAS) (p < 0.001) and correlated well with the neutrophil counts in SF as well (p < 0.001).

Positive_regulation (activated) of MMP-2 in knee joints

15) Confidence 0.46 Published 2004 Journal Clin. Chim. Acta Section Body Doc Link 14687896 Disease Relevance 0.18 Pain Relevance 0

MMP-2 promoter and enzyme activity were up-regulated in Akt kinase activity dependent manner.

Positive_regulation (up-regulated) of MMP-2

16) Confidence 0.44 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 15546138 Disease Relevance 0.65 Pain Relevance 0.20

Immunohistochemistry with antibodies against MMP-2 and elastic van Gieson staining revealed that arterioles express high levels of MMP-2 within 3 months of symptom onset and that intimal hyperplasia proceeded rapidly between 4 and 7 months, resulting in severe vascular narrowing.

Positive_regulation (levels) of MMP-2 in arterioles associated with hyperplasia

17) Confidence 0.43 Published 2005 Journal J. Pathol. Section Abstract Doc Link 15685708 Disease Relevance 0.99 Pain Relevance 0.53

In that vein, the mechanism-based gelatinase inhibitor SB-3CT and its new structural variants stand out.

Positive_regulation (based) of gelatinase in vein

18) Confidence 0.42 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 0.24 Pain Relevance 0

As a negative control, primary antibody was replaced with Tris-buffered saline on sections that were proven to be positive for MMP9, MMP2, type IV collagen, macrophages and CD105 in preliminary experiments.

Positive_regulation (positive) of MMP2 in macrophages

19) Confidence 0.42 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 0.13 Pain Relevance 0

These phenomena were accompanied by a marked increase in gelatinolytic activity (MMP-2 and MMP-9) in the G1 tumor.

Positive_regulation (increase) of MMP-2 associated with cancer

20) Confidence 0.41 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12044784 Disease Relevance 0.77 Pain Relevance 0.35

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