INT55739

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Context Info
Confidence 0.67
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.72
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Timp1) extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
PGE2 2
Timp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 97 100.00 Very High Very High Very High
fibrosis 64 99.12 Very High Very High Very High
Chronic pancreatitis 6 99.04 Very High Very High Very High
agonist 10 97.72 Very High Very High Very High
pulpitis 2 92.84 High High
cytokine 35 91.44 High High
dexamethasone 5 86.72 High High
Inflammation 43 80.48 Quite High
Bile 1 77.64 Quite High
cINOD 2 63.84 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 38 99.36 Very High Very High Very High
Fibrosis 49 99.12 Very High Very High Very High
Pancreatitis 6 99.04 Very High Very High Very High
Cirrhosis 60 98.08 Very High Very High Very High
Pulpitis 2 92.84 High High
Necrosis 6 91.64 High High
Cancer 6 91.28 High High
Injury 32 86.56 High High
Disease 4 80.84 Quite High
INFLAMMATION 47 80.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We showed that TIMPs mRNA and protein level dramatically increase, while MMPs level increase modestly or remain relatively static as well.
Transcription (showed) of TIMP associated with metalloproteinase
1) Confidence 0.67 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.86 Pain Relevance 0.60
TAA treatment increased transcription of both MMPs and TIMPs, but only TIMPs showed increased translation.
Transcription (transcription) of TIMP associated with metalloproteinase
2) Confidence 0.52 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2844613 Disease Relevance 0.68 Pain Relevance 0.38
There were no major effects on MMP-13 mRNA levels by the GLP-2 agonists, under either ambient oxygen status; however, there were interesting statistically significant increases in mRNA levels for TIMP 1, 2, and 3 in hypoxic animals treated with GLP-2-MMB, but not native GLP-2 (data not shown).


Transcription (levels) of TIMP associated with hypoxia and agonist
3) Confidence 0.17 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.73 Pain Relevance 0.24
In vivo, however, this was associated with increased collagen I and III depositions and enhanced tissue inhibitor of metalloproteinase-1 (TIMP-1) mRNA expression.
Transcription (expression) of TIMP-1 associated with metalloproteinase
4) Confidence 0.11 Published 2001 Journal Hepatology Section Abstract Doc Link 11584368 Disease Relevance 0.86 Pain Relevance 0.52
The differential regulation of IL-1alpha or TNF-alpha-induced MMP-1 and TIMP-1 mRNA synthesis, as well as the direct upregulation of TIMP-1 gene expression by PGE2, also implied that prostaglandin may serve as a protective mechanism from excessive tissue breakdown during pulpitis.
Transcription (synthesis) of TIMP-1 in PGE2 associated with pulpitis
5) Confidence 0.06 Published 2001 Journal J Endod Section Abstract Doc Link 11487149 Disease Relevance 0.47 Pain Relevance 0.31
Exogenous PGE2, however, upregulated TIMP-1 mRNA synthesis but not MMP-1.
Transcription (synthesis) of TIMP-1 in PGE2
6) Confidence 0.06 Published 2001 Journal J Endod Section Abstract Doc Link 11487149 Disease Relevance 0.49 Pain Relevance 0.30
Transcripts for MMP-1 (interstitial collagenase), MMP-3 (stromelysin) and TIMP-1 were not detectable in chronic pancreatitis and control tissues.
Transcription (Transcripts) of TIMP-1 associated with chronic pancreatitis
7) Confidence 0.05 Published 1994 Journal Z Gastroenterol Section Abstract Doc Link 8017097 Disease Relevance 0.63 Pain Relevance 0.65

General Comments

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