INT55740

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Context Info
Confidence 0.75
First Reported 1994
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 53
Total Number 56
Disease Relevance 28.63
Pain Relevance 13.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Timp1) extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
PGE2 4
liver 3
hepatocytes 2
ESCs 2
synovial fluid 1
Timp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 689 100.00 Very High Very High Very High
Chronic pancreatitis 12 99.84 Very High Very High Very High
ischemia 119 99.68 Very High Very High Very High
cytokine 173 99.60 Very High Very High Very High
fibrosis 386 99.00 Very High Very High Very High
Inflammation 172 98.64 Very High Very High Very High
Dismenorea 4 98.36 Very High Very High Very High
Snapping jaw 6 97.80 Very High Very High Very High
endometriosis 69 97.08 Very High Very High Very High
pulpitis 7 95.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 12 99.84 Very High Very High Very High
Pancreatic Cancer 7 99.84 Very High Very High Very High
Infarction 217 99.68 Very High Very High Very High
Cv Unclassified Under Development 118 99.68 Very High Very High Very High
Cirrhosis 534 99.64 Very High Very High Very High
Ganglion Cysts 3 99.48 Very High Very High Very High
Aneurism 42 99.40 Very High Very High Very High
Injury 216 99.24 Very High Very High Very High
Fibrosis 292 99.00 Very High Very High Very High
Disease 58 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MMPs and TIMPs protein expression
Gene_expression (expression) of TIMP associated with metalloproteinase
1) Confidence 0.75 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.64 Pain Relevance 0.41
Differential expression of both MMPs and TIMPs occurs in fibrotic liver disease and hepatocellular carcinoma (2, 3, 11-13).
Gene_expression (expression) of TIMP in liver associated with cirrhosis, hepatocellular cancer, metalloproteinase and disease
2) Confidence 0.75 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.97 Pain Relevance 0.62
However, just like the Casp4 gene, since the difference in two groups is not considerable, it is difficult to conclude that propofol plays an important role for the Timp1 gene expression in the ischemia-reperfusion model.
Gene_expression (expression) of Timp1 gene associated with ischemia
3) Confidence 0.68 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872860 Disease Relevance 1.12 Pain Relevance 0.24
While gene expression of Abcc9, Bard1 and Casp4 has increased significantly in the Post group, compared to Ischemic group, gene expression of Lyz, Timp1 and Casp8 has reduced significantly.
Gene_expression (expression) of Timp1
4) Confidence 0.68 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872860 Disease Relevance 0.53 Pain Relevance 0.30
MMPs and TIMPs mRNA
Gene_expression (mRNA) of TIMP associated with metalloproteinase
5) Confidence 0.65 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.37 Pain Relevance 0.36
Thus, overexpression of TIMPs inhibits the ECM-degrading functions of MMPs may explain the establishment and maintenance of liver fibrosis.
Gene_expression (overexpression) of TIMP in liver associated with fibrosis, cirrhosis and metalloproteinase
6) Confidence 0.65 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.90 Pain Relevance 0.63
The dominant expression of TIMPs may regulate the function of MMPs to maintain liver fibrosis induced by TAA.



Gene_expression (expression) of TIMP in liver associated with fibrosis, cirrhosis and metalloproteinase
7) Confidence 0.58 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2844613 Disease Relevance 0.74 Pain Relevance 0.46
Following liver injury, HSCs are activated and increase the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) (3, 4).
Gene_expression (expression) of TIMP in HSCs associated with cirrhosis, injury and metalloproteinase
8) Confidence 0.58 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 1.22 Pain Relevance 0.51
To this respect, our results demonstrate that increased TIMP expression is more critical than MMPs in TAA-induced fibrogenesis.
Gene_expression (expression) of TIMP associated with fibrosis and metalloproteinase
9) Confidence 0.54 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.90 Pain Relevance 0.59
MMPs are expressed in HSCs or hepatocytes (22), whereas TIMP-1 and TIMP-2 are expressed only in HSCs (23).
Gene_expression (expressed) of TIMP-1 in hepatocytes associated with cirrhosis and metalloproteinase
10) Confidence 0.54 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 1.13 Pain Relevance 0.48
MMPs are expressed in HSCs or hepatocytes (22), whereas TIMP-1 and TIMP-2 are expressed only in HSCs (23).
Gene_expression (expressed) of TIMP in hepatocytes associated with cirrhosis and metalloproteinase
11) Confidence 0.54 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 1.12 Pain Relevance 0.47
TIMP-1 (tissue inhibitor of metallopeptidase1) expression is regulated through STAT3 [38] and TIMP-1 is induced in the epiretinal membranes of Type 1 and Type 2 diabetic patients [39].
Gene_expression (expression) of TIMP-1 associated with epiretinal membrane and diabetes mellitus
12) Confidence 0.53 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 1.13 Pain Relevance 0.23
On the results of RT-PCR, the expressions of Abcc9, Bard1, and Casp4 were increased, but the expressions of Lyz, Casp8, and Timp1 were decreased in the Post group compared with the Ischemic group.


Gene_expression (expressions) of Timp1
13) Confidence 0.53 Published 2010 Journal Korean Journal of Anesthesiology Section Abstract Doc Link PMC2872860 Disease Relevance 0.33 Pain Relevance 0.16
Levels of TIMP-1, TIMP-2 and TGF-?
Gene_expression (Levels) of TIMP-1
14) Confidence 0.45 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.28 Pain Relevance 0
1 down-regulation caused by SDF-1 was associated with decreased collagen accumulation and down-regulated TIMP-1 expression in the infarction area.
Gene_expression (expression) of TIMP-1 associated with infarction
15) Confidence 0.45 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.64 Pain Relevance 0.08
Highest TIMP-1, TIMP-2 and TGF-?
Gene_expression (Highest) of TIMP-1
16) Confidence 0.39 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.23 Pain Relevance 0
1, TIMP-1 and TIMP-2 expression in AdV-SDF-1 group.
Gene_expression (expression) of TIMP-1
17) Confidence 0.39 Published 2009 Journal Mol Biol Rep Section Abstract Doc Link PMC2831180 Disease Relevance 0.42 Pain Relevance 0
Interestingly, TIMP-1 overexpression in pancreatic cancer cells reduced angiogenesis and cell implantation, this anti-angiogenic activity of TIMP-1 involved in part MMP-inhibition [33].
Gene_expression (overexpression) of TIMP-1 associated with pancreatic cancer
18) Confidence 0.35 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.15 Pain Relevance 0.07
In our study, we observed that expression of Tissue inhibitors of metalloproteinases (TIMP1, 2) decreased in infarction area of myocardium in the AdV-SDF-1 group, which was concordance with much more stem cells and blood vessels.
Gene_expression (expression) of TIMP1 in blood vessels associated with metalloproteinase and infarction
19) Confidence 0.35 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.18 Pain Relevance 0.08
Following examinations for pain upon joint movements and X-ray and MRI observations, the IL-1 beta, IL-6, and TIMP-1 levels and frequencies of their detection were compared.
Gene_expression (detection) of TIMP-1 in joint
20) Confidence 0.25 Published 2000 Journal Oral Dis Section Body Doc Link 11355271 Disease Relevance 0.23 Pain Relevance 0

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