INT55741

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Context Info
Confidence 0.51
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 8.12
Pain Relevance 4.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Timp1) extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
plasma 1
joint 1
pancreas 1
pituitary 1
brain 1
Timp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 209 100.00 Very High Very High Very High
Chronic pancreatitis 6 99.52 Very High Very High Very High
Inflammatory mediators 2 99.42 Very High Very High Very High
Inflammation 124 98.64 Very High Very High Very High
cytokine 52 98.34 Very High Very High Very High
Snapping jaw 2 97.80 Very High Very High Very High
Angina 5 96.28 Very High Very High Very High
Pain 2 95.00 High High
fibrosis 103 94.32 High High
imagery 1 93.40 High High
Disease Link Frequency Relevance Heat
Pancreatitis 6 99.52 Very High Very High Very High
Natriuresis 11 99.24 Very High Very High Very High
INFLAMMATION 135 99.22 Very High Very High Very High
Ganglion Cysts 4 98.88 Very High Very High Very High
Apoptosis 69 98.54 Very High Very High Very High
Pituitary Cancer 11 98.44 Very High Very High Very High
Temporomandibular Joint Syndrome 2 97.80 Very High Very High Very High
Myocardial Infarction 8 97.36 Very High Very High Very High
Epiretinal Membrane 1 97.04 Very High Very High Very High
Cirrhosis 46 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it does affect the apoptosis process since there was an increase in expression of the Casp4 gene and reduction in the Timp1 gene.
Negative_regulation (reduction) of Timp1 gene associated with apoptosis
1) Confidence 0.51 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872860 Disease Relevance 0.75 Pain Relevance 0.14
In addition, the Bard1 and Casp4 genes are significantly increased, while the Casp8 and Timp1 genes are significantly decreased compared to the
Negative_regulation (decreased) of Timp1
2) Confidence 0.38 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872860 Disease Relevance 0.34 Pain Relevance 0.10
TIMP-1 (tissue inhibitor of metallopeptidase1) expression is regulated through STAT3 [38] and TIMP-1 is induced in the epiretinal membranes of Type 1 and Type 2 diabetic patients [39].
Negative_regulation (inhibitor) of metallopeptidase1 associated with epiretinal membrane and diabetes mellitus
3) Confidence 0.34 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 1.12 Pain Relevance 0.23
OBJECTIVE: The distribution and biological roles of interleukin (IL)-1 beta, IL-6, and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the synovial fluid of patients with non-inflammatory chronic temporomandibular joint (TMJ) disorders were evaluated in relation to pain upon joint movements and X-ray and magnetic resonance imaging (MRI) findings.
Negative_regulation (inhibitor) of TIMP-1 in joint associated with pain, snapping jaw, inflammation, metalloproteinase and imagery
4) Confidence 0.16 Published 2000 Journal Oral Dis Section Abstract Doc Link 11355271 Disease Relevance 0.37 Pain Relevance 0.45
AIMS: We sought to determine the association between two major biomarkers, the inactive N-terminal fragment of brain natriuretic peptide (NT-proBNP) and tissue inhibitor of metalloproteinase-1 (TIMP-1) and long-term cardiovascular outcomes in a cohort of subjects who had a myocardial infarction or unstable angina 3-36 months previously.
Negative_regulation (inhibitor) of TIMP-1 in brain associated with natriuresis, angina, metalloproteinase and myocardial infarction
5) Confidence 0.15 Published 2008 Journal Eur. Heart J. Section Abstract Doc Link 18296678 Disease Relevance 0.37 Pain Relevance 0.18
Matrix metalloproteinase (MMP) is a group of Zn-dependent proteinases activated by proteolytic removal of their amino terminal, and their actions are inhibited by specific inhibitors, tissue inhibitors of matrix metalloproteinases (TIMP).2 MMP-2 and MMP-9 are designated as 72-kDa gelatinase A and 92-kDa gelatinase B, respectively, and well known by their ability of degrading collagen type IV, the major constituent of the basement membrane.
Negative_regulation (inhibitors) of TIMP in basement membrane associated with metalloproteinase
6) Confidence 0.15 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.69 Pain Relevance 0.62
1 and TIMP-1 were markedly downregulated by the end of treatment.
Negative_regulation (downregulated) of TIMP-1
7) Confidence 0.12 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.62 Pain Relevance 0.31
Because commercial kits for the measurement of mouse or rat matrix metalloproteinase 1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were not available, we used TWNT-4 cells, a human cell line derived from HSCs (16), to evaluate the effects of NIM811 on MMP-1 and TIMP-1.
Negative_regulation (inhibitor) of TIMP-1 associated with cirrhosis and metalloproteinase
8) Confidence 0.11 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.72 Pain Relevance 0.14
The alcoholic and aqueous extracts of T. cordifolia are reported to have beneficial effects on the immune system[8187] and have been tested successfully for their immunomodulatory activity.[97-103] The degradation of proteins due to photosensitization as assessed by Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) was effectively reduced by simultaneous treatment with G1-4A/PPI (partially purified immunomodulator) from T. cordifolia during photosensitization.[104] The novel (1,4)-alpha-D-glucan derived from the plant activates the immune system through the activation of macrophages via TLR6 signaling, NFkappaB translocation and cytokine production.[32105] Tinospora cordifolia differentially regulate elevation of cytokines as evidenced by the increased production of antiangiogenic agents IL-2 and tissue inhibitor of metalloprotease-1 (TIMP-1) in the B16F10-injected, extract-treated animals.
Negative_regulation (inhibitor) of TIMP-1 in immune system associated with photosensitivity disorders and cytokine
9) Confidence 0.08 Published 2010 Journal International Journal of Ayurveda Research Section Body Doc Link PMC2924974 Disease Relevance 0.55 Pain Relevance 0.14
CONCLUSION: AMI patients treated with PCI had an early significant reduction in MMP-9, MMP-9/TIMP-1 ratio and PAPP-A when compared to patients with stable angina pectoris treated with PCI.
Negative_regulation (reduction) of TIMP-1
10) Confidence 0.04 Published 2009 Journal Thromb. Res. Section Body Doc Link 19410278 Disease Relevance 0.06 Pain Relevance 0
UNLABELLED: The objective of this study was to investigate the time profiles of plasma matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinases (TIMP-1 and -2), and pregnancy associated plasma protein A (PAPP-A) in patients with acute myocardial infarction (AMI), compared to patients with stable angina pectoris (AP), all treated with percutaneous coronary intervention (PCI) with stent.
Negative_regulation (inhibitor) of TIMP-1 in plasma associated with stable angina pectoris, angina, metalloproteinase and myocardial infarction
11) Confidence 0.04 Published 2009 Journal Thromb. Res. Section Abstract Doc Link 19410278 Disease Relevance 0.34 Pain Relevance 0.31
The peptide up-regulated tissue inhibitor of metalloproteinase (TIMP)-1, TIMP-2, and TIMP-3 gene expression on day 1 in AF cells but had very little effect on their expression in NP cells.
Negative_regulation (inhibitor) of TIMP associated with metalloproteinase
12) Confidence 0.04 Published 2008 Journal The Open Orthopaedics Journal Section Abstract Doc Link PMC2685046 Disease Relevance 0.06 Pain Relevance 0.34
These are secreted as a pro-enzyme in response to several inflammatory mediators and are inhibited by tissue inhibitor of metalloproteinase-1 (TIMP-1) and tissue inhibitor of metalloproteinase-2 (TIMP-2).
Negative_regulation (inhibitor) of TIMP-1 associated with inflammatory mediators and metalloproteinase
13) Confidence 0.04 Published 2009 Journal Prz. Lek. Section Abstract Doc Link 20043576 Disease Relevance 0.35 Pain Relevance 0.37
In this study we analyzed the balance of expression of mRNAs encoding extracellular matrix components (collagens I, III and IV, laminin, fibronectin), extracellular matrix degrading metalloproteinases (MMP-1, -2 and -3) and tissue inhibitors of metalloproteinases (TIMP-1 and -2) in chronic pancreatitis (n = 8) and control pancreas (n = 7) by northern blot analysis.
Negative_regulation (inhibitors) of TIMP-1 in pancreas associated with metalloproteinase and chronic pancreatitis
14) Confidence 0.03 Published 1994 Journal Z Gastroenterol Section Abstract Doc Link 8017097 Disease Relevance 0.52 Pain Relevance 0.56
This is particularly prominent in pituitary adenomas in which very high levels of active MMP-2 and MMP-9 and low levels of tissue inhibitor of metalloproteinases-1 have been reported (825).
Negative_regulation (inhibitor) of metalloproteinases-1 in pituitary associated with pituitary cancer and metalloproteinase
15) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.27 Pain Relevance 0.20

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