INT55743

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Context Info
Confidence 0.31
First Reported 1994
Last Reported 2009
Negated 0
Speculated 3
Reported most in Body
Documents 25
Total Number 30
Disease Relevance 8.95
Pain Relevance 4.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Timp2) aging (Timp2) extracellular region (Timp2)
nucleus (Timp2)
Anatomy Link Frequency
endometrium 4
brain 3
plasma 2
ESCs 2
fibroblast 1
Timp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 114 100.00 Very High Very High Very High
Inflammation 12 100.00 Very High Very High Very High
antagonist 1 100.00 Very High Very High Very High
Chronic pancreatitis 12 99.68 Very High Very High Very High
cytokine 65 99.60 Very High Very High Very High
endometriosis 14 99.56 Very High Very High Very High
Dismenorea 11 98.84 Very High Very High Very High
Angina 1 97.72 Very High Very High Very High
Restless leg syndrome 1 97.54 Very High Very High Very High
fibrosis 12 94.24 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 13 100.00 Very High Very High Very High
Acute Coronary Syndrome 2 100.00 Very High Very High Very High
Pancreatitis 12 99.68 Very High Very High Very High
Endometriosis (extended) 14 99.56 Very High Very High Very High
Cv Unclassified Under Development 4 99.08 Very High Very High Very High
Dupuytren's Disease 8 98.88 Very High Very High Very High
Dysmenorrhea 11 98.84 Very High Very High Very High
Contracture 4 98.40 Very High Very High Very High
Cv General 3 Under Development 1 97.72 Very High Very High Very High
Increased Venous Pressure Under Development 1 97.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: Immunohistochemical staining of tissues was performed to study the expressions and locations of MMP-2, MMP-3, TIMP-2 between women with and without endometriosis.
Gene_expression (expressions) of TIMP-2
1) Confidence 0.31 Published 2006 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 16468658 Disease Relevance 0.19 Pain Relevance 0
OBJECTIVE: To investigate the expressions of matrix metalloproteinase -2, -3 (MMP-2,-3) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in internal uterine endometriosis tissue and endometrium from women with and without endometriosis throughout the menstrual cycle.
Spec (investigate) Gene_expression (expressions) of TIMP-2 in internal associated with endometriosis and metalloproteinase
2) Confidence 0.31 Published 2006 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Abstract Doc Link 16468658 Disease Relevance 0.27 Pain Relevance 0.35
All eutopic and ectopic endometrium samples from women with and without endometriosis throughout the menstrual cycle showed similar expressions of MMP-2, MMP-3 and TIMP-2.
Gene_expression (expressions) of TIMP-2 in endometrium
3) Confidence 0.31 Published 2006 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 16468658 Disease Relevance 0.13 Pain Relevance 0
RESULTS: We found that ectopic endometrium from patients with endometriosis expressed higher levels of MMP-2 and MMP-3 and lower levers of TIMP-2 than normal controls did (P < 0.05).
Gene_expression (expressed) of TIMP-2 in endometrium
4) Confidence 0.31 Published 2006 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 16468658 Disease Relevance 0.17 Pain Relevance 0
Quantitative expressions of MMP-2 mRNA, MMP-3 mRNA and TIMP-2 mRNA were significantly lower in eutopic endometrium from controls compared with ectopic endometrium from patients with endometriosis (P < 0.05).
Gene_expression (expressions) of TIMP-2 mRNA in endometrium
5) Confidence 0.31 Published 2006 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 16468658 Disease Relevance 0.13 Pain Relevance 0
The real-time PCR technique was applied to detected the mRNA expressions of MMP-2, MMP-3 and TIMP-2.
Gene_expression (expressions) of TIMP-2
6) Confidence 0.24 Published 2006 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 16468658 Disease Relevance 0.18 Pain Relevance 0
CONCLUSION: The results suggest that ectopic endometrium with adenomyosis has more invasiveness and is prone to peritoneal implantation maybe to involved in the high expressions of MMP-2 and MMP-3 and the less expressions of TIMP-2 than endometrium from women without adenomyosis does.


Gene_expression (expressions) of TIMP-2 in endometrium
7) Confidence 0.24 Published 2006 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 16468658 Disease Relevance 0 Pain Relevance 0
The exception was for tissue inhibitor of metalloproteinase-1 (TIMP-1) and tissue inhibitor of metalloproteinase-2 (TIMP-2), which were detected in ACCS at the upper limit of known physiological levels.
Gene_expression (detected) of TIMP-2 in upper associated with metalloproteinase
8) Confidence 0.22 Published 2008 Journal Eplasty Section Body Doc Link PMC2323202 Disease Relevance 0.34 Pain Relevance 0.43
Levels of TIMP-1, TIMP-2 and TGF-?
Gene_expression (Levels) of TIMP-2
9) Confidence 0.21 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.28 Pain Relevance 0
Highest TIMP-1, TIMP-2 and TGF-?
Gene_expression (Highest) of TIMP-2
10) Confidence 0.19 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.23 Pain Relevance 0
1, TIMP-1 and TIMP-2 expression in AdV-SDF-1 group.
Gene_expression (expression) of TIMP-2
11) Confidence 0.19 Published 2009 Journal Mol Biol Rep Section Abstract Doc Link PMC2831180 Disease Relevance 0.42 Pain Relevance 0
The purpose of this study was to compare the expression patterns of TGF-beta1, MMP-2, and TIMP-2 between autoimmune chronic pancreatitis (AIP) and alcoholic chronic pancreatitis (ACP) by immunohistochemical staining of pancreatic tissue specimens.
Gene_expression (expression) of TIMP-2 associated with chronic pancreatitis
12) Confidence 0.17 Published 2009 Journal Pancreas Section Abstract Doc Link 19546837 Disease Relevance 0.73 Pain Relevance 0.41
The purpose of this study was to compare the expression patterns of TGF-beta1, MMP-2, and TIMP-2 between autoimmune chronic pancreatitis (AIP) and alcoholic chronic pancreatitis (ACP) by immunohistochemical staining of pancreatic tissue specimens.
Gene_expression (expression) of TIMP-2 associated with chronic pancreatitis
13) Confidence 0.15 Published 2009 Journal Pancreas Section Abstract Doc Link 19546837 Disease Relevance 0.73 Pain Relevance 0.41
TIMP-1 and TIMP-2 could be detected in tissue of patients with Dupuytren's contracture, with an accumulation in proliferative areas.
Gene_expression (detected) of TIMP-2 associated with dupuytren's disease and contracture
14) Confidence 0.12 Published 2003 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 14504511 Disease Relevance 1.26 Pain Relevance 0.25
RESULTS: While we found similar TIMP-2 levels, higher plasma pro-MMP-2 and pro-MMP-2/TIMP-2 ratios were found in MWA and MA patients compared with controls (P<0.05).
Gene_expression (levels) of TIMP-2 in plasma
15) Confidence 0.11 Published 2009 Journal Clin. Chim. Acta Section Body Doc Link 19627981 Disease Relevance 0.26 Pain Relevance 0
RESULTS: While we found similar TIMP-2 levels, higher plasma pro-MMP-2 and pro-MMP-2/TIMP-2 ratios were found in MWA and MA patients compared with controls (P<0.05).
Gene_expression (found) of TIMP-2 in plasma
16) Confidence 0.11 Published 2009 Journal Clin. Chim. Acta Section Body Doc Link 19627981 Disease Relevance 0.26 Pain Relevance 0
We hypothesized that patients with intermittent claudication (with low ankle-brachial blood pressure index, <0.8), and critical ischaemia would have raised circulating levels of MMP-9, TIMP-1 and TIMP-2 compared with healthy controls, reflecting an increase in proteolytic activity which may be related to ECM turnover in PAD.
Gene_expression (levels) of TIMP-2 in ECM associated with restless leg syndrome, cv unclassified under development and peripheral arterial disease
17) Confidence 0.09 Published 2005 Journal J. Intern. Med. Section Abstract Doc Link 15606382 Disease Relevance 0.61 Pain Relevance 0.14
OBJECTIVE: To investigate cell invasiveness and the production of matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 in endometrial stromal cells (ESCs) of adenomyosis.
Spec (investigate) Gene_expression (production) of TIMP-2 in ESCs associated with dismenorea and metalloproteinase
18) Confidence 0.09 Published 2009 Journal Fertil. Steril. Section Abstract Doc Link 18692810 Disease Relevance 0.17 Pain Relevance 0.35
Furthermore, the expression levels of Ang, brain-derived neurotrophic factor (BDNF), FGF-4, FGF-9, IGFBP-2, IL-8, MIP-1beta, OPG, pulmonary and activation-regulated protein (PARC), TGF-beta2, TIMP-2 and VEGF were significantly associated with the presence of JE; among these, nine cytokines (Ang, BDNF, FGF-4, FGF-9, IGFBP-2, MIP-1beta, PARC, TGF-beta2 and TIMP-2) were hitherto not described in TMD.
Gene_expression (expression) of TIMP-2 in brain
19) Confidence 0.06 Published 2006 Journal Dentomaxillofac Radiol Section Body Doc Link 17082335 Disease Relevance 0.13 Pain Relevance 0
In the majority of synovial fluid samples, angiogenin (Ang), fibroblast growth factor (FGF)-9, insulin-like growth factor-binding protein (IGFBP)-3, interleukin (IL)-1alpha, IL-1beta, IL-8, inducible protein (IP)-10, macrophage inflammatory protein (MIP)-1beta, osteoprotegerin (OPG), transforming growth factor (TGF)-beta2, tissue inhibitor of metalloproteinase (TIMP)-1, TIMP-2, tumour necrosis factor (TNF)-beta and vascular endothelial growth factor (VEGF) were detectable.
Gene_expression (detectable) of TIMP-2 in fibroblast
20) Confidence 0.06 Published 2006 Journal Dentomaxillofac Radiol Section Body Doc Link 17082335 Disease Relevance 0.14 Pain Relevance 0

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