INT55758

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Context Info
Confidence 0.70
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 11.71
Pain Relevance 4.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
brains 2
astrocyte 2
glial cell 1
neuron 1
Cerebrospinal fluid 1
Apoe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 39 99.82 Very High Very High Very High
anesthesia 3 99.78 Very High Very High Very High
backache 4 99.76 Very High Very High Very High
aspirin 20 99.58 Very High Very High Very High
Inflammation 73 95.00 High High
Pyramidal cell 24 94.16 High High
psoriasis 145 92.88 High High
Arthritis 15 77.96 Quite High
Central nervous system 7 76.08 Quite High
Multiple sclerosis 49 74.48 Quite High
Disease Link Frequency Relevance Heat
Psoriasis 156 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 115 100.00 Very High Very High Very High
Disease 132 99.84 Very High Very High Very High
Low Back Pain 5 99.76 Very High Very High Very High
Motor Neuron Diseases 4 99.00 Very High Very High Very High
Meningoencephalitis 4 98.12 Very High Very High Very High
Injury 7 97.20 Very High Very High Very High
INFLAMMATION 88 95.00 High High
Atherosclerosis 13 93.68 High High
Demyelinating Disease 60 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, treatment of primary rat mixed glial cell cultures with the common NSAIDs, indomethacin and aspirin, induced significant increases in extracellular apoE protein levels.
Positive_regulation (increases) of apoE in glial cell associated with aspirin and cinod
1) Confidence 0.70 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511323 Disease Relevance 0.68 Pain Relevance 0.54
Similarly, treatment of primary rat astrocyte cell cultures with aspirin and a cyclooxygenase (COX)-2-selective aspirin derivative also stimulated significant increases in apoE protein.
Positive_regulation (increases) of apoE in astrocyte associated with aspirin
2) Confidence 0.70 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511323 Disease Relevance 0.63 Pain Relevance 0.62
Consequently, NSAID-induced increases in apoE protein may enhance apoE-mediated immunosuppression and compensatory synaptic plasticity, potentially resulting in decreased AD risk and delay of disease onset.
Positive_regulation (increases) of apoE associated with cinod and disease
3) Confidence 0.70 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511323 Disease Relevance 0.60 Pain Relevance 0.56
The failure of NSAIDs to significantly alter apoE expression may have been indicative of a nontranscriptional mechanism of apoE protein induction.
Positive_regulation (induction) of apoE associated with cinod
4) Confidence 0.70 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511323 Disease Relevance 0.42 Pain Relevance 0.57
Higher levels of CSF apoE were also present in a subset of patients with meningoencephalitis, motor neuron disease, and low back pain.
Positive_regulation (levels) of apoE in motor neuron associated with low back pain, meningoencephalitis, motor neuron diseases and backache
5) Confidence 0.65 Published 1997 Journal J. Neurol. Sci. Section Abstract Doc Link 9073026 Disease Relevance 1.24 Pain Relevance 0.13
The increase of CSF-apoE in AD is in agreement with results from studies that find an increase of mRNA apoE in the brains of AD patients.
Positive_regulation (increase) of apoE in brains associated with disease
6) Confidence 0.65 Published 1997 Journal J. Neurol. Sci. Section Abstract Doc Link 9073026 Disease Relevance 1.23 Pain Relevance 0.14
The increase of CSF-apoE in AD is in agreement with results from studies that find an increase of mRNA apoE in the brains of AD patients.
Positive_regulation (increase) of apoE in brains associated with disease
7) Confidence 0.65 Published 1997 Journal J. Neurol. Sci. Section Abstract Doc Link 9073026 Disease Relevance 1.20 Pain Relevance 0.14
Cerebrospinal fluid apolipoprotein E level is increased in late-onset Alzheimer's disease.
Positive_regulation (increased) of apolipoprotein E in Cerebrospinal fluid associated with disease and disorder of lipid metabolism
8) Confidence 0.56 Published 1997 Journal J. Neurol. Sci. Section Title Doc Link 9073026 Disease Relevance 1.18 Pain Relevance 0.10
In contrast to these results, indomethacin and aspirin treatment failed to induce any significant changes in apoE mRNA levels.
Neg (failed) Positive_regulation (induce) of apoE associated with aspirin
9) Confidence 0.50 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511323 Disease Relevance 0.51 Pain Relevance 0.70
In recent years, some researchers conformed that astrocytes generated apoA-I and apoE in rat, apoA-I facilitated translocation of newly synthesized cholesterol and phospholipid to cytosol to form the lipid-protein complex particles as an initial event in cholesterol trafficking for the assembly of HDL, and found cholesterol efflux from rat astrocytes induced by apoA-I and apoE.
Positive_regulation (generated) of apoE in astrocytes associated with disorder of lipid metabolism
10) Confidence 0.43 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2860353 Disease Relevance 0.88 Pain Relevance 0.30
Furthermore, the enhanced apo E immunoreactivity was also detected in the stratum oriens and radiatum of the CA1 region.
Positive_regulation (enhanced) of apo E
11) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.15 Pain Relevance 0.15
Numerous factors have been shown to be increased in the serum of psoriatic patients including apolipoprotein E (ApoE), vascular endothelial growth factor (VEGF), sICAM-1, IL-8, soluble interleukin2 receptor (sIL-2R) and TNF?
Positive_regulation (increased) of apolipoprotein E associated with psoriasis and disorder of lipid metabolism
12) Confidence 0.21 Published 2006 Journal Arch Dermatol Res Section Body Doc Link PMC1705513 Disease Relevance 1.37 Pain Relevance 0.36
Arterial blood samples were drawn before and 8 and 24 h after induction of anesthesia and later assayed for neuron specific enolase (NSE), S-100beta, and apoE genotype.
Positive_regulation (assayed) of apoE in neuron associated with anesthesia
13) Confidence 0.18 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15502024 Disease Relevance 0.26 Pain Relevance 0.18
Fluvastatin significantly increased LpA-I (+8%) and apo E (+20%).
Positive_regulation (increased) of apo E
14) Confidence 0.05 Published 1994 Journal Am. J. Med. Section Abstract Doc Link 8017468 Disease Relevance 0.92 Pain Relevance 0.20
The peak between fractions 25 and 28 contained apo A-II (which was significantly decreased in the patients) and apo E (which was significantly increased), but not PON1.
Positive_regulation (increased) of apo E
15) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.44 Pain Relevance 0

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