INT55784

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Context Info
Confidence 0.24
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.93
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Neu1) cytoplasmic membrane-bounded vesicle (Neu1) plasma membrane (Neu1)
molecular_function (Neu1) cellular_component (Neu1) biological_process (Neu1)
Anatomy Link Frequency
neutrophils 1
Neu1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 1 94.36 High High
Analgesic 1 91.68 High High
Inflammation 2 85.28 High High
abdominal pain 5 66.24 Quite High
nud 1 33.76 Quite Low
Disease Link Frequency Relevance Heat
Inborn Error Of Metabolism 1 99.70 Very High Very High Very High
Pancreatitis 4 99.62 Very High Very High Very High
Fabry Disease 4 98.90 Very High Very High Very High
Influenza Virus Infection 97 96.16 Very High Very High Very High
Injury 1 95.96 Very High Very High Very High
Pressure And Volume Under Development 2 95.48 Very High Very High Very High
Syndrome 1 89.12 High High
Infection 9 86.32 High High
Sprains And Strains 9 78.48 Quite High
Ulcers 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that cetraxate plays its protective roles against pancreatitis by inhibiting the redistribution of lysosomal enzyme and by activation of trypsinogen; such activities may be clinically useful in preventing pancreatic injuries, particularly in patients with chronic pancreatitis.
Negative_regulation (redistribution) of lysosomal enzyme associated with injury, pancreatitis and chronic pancreatitis
1) Confidence 0.24 Published 1994 Journal J. Int. Med. Res. Section Abstract Doc Link 8020637 Disease Relevance 0.68 Pain Relevance 0.09
Moreover, the extracts suppressed the release of beta-glucuronidase, a lysosomal enzyme in rat neutrophils.
Negative_regulation (suppressed) of lysosomal enzyme in neutrophils
2) Confidence 0.22 Published 1998 Journal Arch. Pharm. Res. Section Abstract Doc Link 9875511 Disease Relevance 0.26 Pain Relevance 0.17
Consistent with pre-treatment samples taken before the start of clinical trials,50 surveillance during 1996–99, before oseltamivir and zanamivir were introduced, showed no evidence of naturally occurring resistance.49 Resistance remained at a low level after the introduction of the neuraminidase inhibitors.
Negative_regulation (inhibitors) of neuraminidase
3) Confidence 0.06 Published 2010 Journal Journal of Antimicrobial Chemotherapy Section Body Doc Link PMC2835508 Disease Relevance 0.47 Pain Relevance 0
Gastrointestinal symptoms are often an early and prominent manifestation of Fabry disease, an X-linked inborn error of metabolism caused by the deficient activity of the lysosomal enzyme, alpha-galactosidase A.
Negative_regulation (deficient) of lysosomal enzyme associated with inborn error of metabolism and fabry disease
4) Confidence 0.01 Published 2005 Journal Mol. Genet. Metab. Section Abstract Doc Link 15939645 Disease Relevance 0.53 Pain Relevance 0.07

General Comments

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