INT55794

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Context Info
Confidence 0.36
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.68
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Crlf2) plasma membrane (Crlf2)
Anatomy Link Frequency
Notch 1
Crlf2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 21 100.00 Very High Very High Very High
Delta opioid receptors 2 97.32 Very High Very High Very High
agonist 66 90.60 High High
Enkephalin 2 90.48 High High
Opioid 2 82.80 Quite High
opioid receptor 1 79.76 Quite High
Neuropeptide 3 75.92 Quite High
MU agonist 1 75.00 Quite High
Cannabinoid receptor 15 50.00 Quite Low
Inflammation 15 28.00 Quite Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 161 92.72 High High
Manic Depressive Disorder 1 82.88 Quite High
Cancer 60 66.64 Quite High
Pancreatic Cancer 1 53.68 Quite High
Colon Cancer 1 52.16 Quite High
Targeted Disruption 6 49.36 Quite Low
Cervical Cancer 1 49.20 Quite Low
Renal Cancer 1 47.84 Quite Low
Lymphatic System Cancer 1 45.12 Quite Low
Apoptosis 6 35.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of any one of the Notch ligands (Delta1 (DLL-1) or Jagged1 (JAG-1), for example) promotes a sequence of proteolytic cleavages resulting in the activated Notch intracellular domain (NICD).
Delta1 Binding (Binding) of in Notch
1) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.68 Pain Relevance 0
Further pharmacological evaluations suggested that they actually interact primarily with the delta 1 and delta 2 receptor subtypes, respectively.
delta 1 Binding (interact) of
2) Confidence 0.03 Published 1994 Journal J. Med. Chem. Section Abstract Doc Link 8021915 Disease Relevance 0 Pain Relevance 0.45
interaction with its heterodimer type II cytokine receptor, the JAKs are directly activated leading to STAT1 phosphorylation [35,36,38].
type II cytokine receptor Binding (its) of associated with cytokine
3) Confidence 0.02 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.20
interaction with its heterodimer type II cytokine receptor, the JAKs are directly activated leading to STAT1 phosphorylation [35,36,38].
type II cytokine receptor Binding (heterodimer) of associated with cytokine
4) Confidence 0.02 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.20
interaction with its heterodimer type II cytokine receptor, the JAKs are directly activated leading to STAT1 phosphorylation [35,36,38].
type II cytokine receptor Binding (interaction) of associated with cytokine
5) Confidence 0.02 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0.20

General Comments

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