INT55810

Context Info Confidence 0.41 First Reported 1994 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 10 Total Number 10 Disease Relevance 4.95 Pain Relevance 2.02

extracellular space (Crp)

Anatomy Link Frequency CD86 2 Plasma 2 monocytes 2 Crp (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 9 100.00 cytokine 4 99.20 ischemia 10 91.84 Inflammation 54 87.48 Inflammatory marker 5 85.60 cINOD 2 85.40 Kinase C inhibitor 1 82.16 adenocard 1 81.76 bradykinin 1 80.88 Kinase C 1 80.56

Disease Link Frequency Relevance Heat Injury 6 99.60 Increased Venous Pressure Under Development 7 95.20 Reperfusion Injury 7 92.60 Cv Unclassified Under Development 8 91.84 Cardiovascular Disease 56 91.68 Infection 57 89.80 Hypertension 36 88.68 Vasculitis 11 87.48 Acute-phase Reaction 1 87.28 INFLAMMATION 51 85.60

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This therapy also reduces a marked CRP elevation typically occurring after invasive coronary intervention.

Negative_regulation (reduces) of Positive_regulation (elevation) of CRP

1) Confidence 0.41 Published 2004 Journal Kardiol Pol Section Body Doc Link 15531933 Disease Relevance 0 Pain Relevance 0

In the Women’s Health Study which included over 15,000 women, after adjustment for the effects of other cardiovascular risk factors, high levels of CRP appeared to be predictive of cardiovascular events either in the absence or presence of high BP.

Negative_regulation (predictive) of Positive_regulation (levels) of CRP

2) Confidence 0.39 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 0.42 Pain Relevance 0.12

In our recent study, the results demonstrate that monocytes exhibit an enhanced production of interleukin-6 (IL-6) in response to CRP, and this response is significantly inhibited by simvastatin in a dose-dependent manner.

Negative_regulation (inhibited) of Positive_regulation (response) of CRP in monocytes

3) Confidence 0.39 Published 2004 Journal Med. Hypotheses Section Abstract Doc Link 15050096 Disease Relevance 1.49 Pain Relevance 0.26

Plasma levels of C-reactive protein (CRP), von Willebrand factor (vWF), IL-6, IL-10 and TNF-alpha were significantly increased by acetaminophen treatment (P < 0.05); and SAC or SPC intake significantly suppressed acetaminophen-induced elevation of CRP, vWF and the three cytokines (P < 0.05).

Negative_regulation (suppressed) of Positive_regulation (elevation) of CRP in Plasma associated with paracetamol and cytokine

4) Confidence 0.35 Published 2006 Journal Food Chem. Toxicol. Section Abstract Doc Link 16181716 Disease Relevance 0.22 Pain Relevance 0.70

It reflected very well the increase in cardiac isoenzymes, infarct size and mortality of the rats, and can be used as a marker of the severity of myocardial injury in this model; The increase of CRP was prevented by both IPC and CPC in early, and especially in late preconditioning.

Negative_regulation (prevented) of Positive_regulation (increase) of CRP associated with injury

5) Confidence 0.24 Published 2004 Journal Life Sci. Section Abstract Doc Link 15193950 Disease Relevance 1.06 Pain Relevance 0.55

In complicated cases, CRP elevation generally persisted after postoperative day 2, whereas WBC counts were within normal ranges in the early postoperative period.

Negative_regulation (persisted) of Positive_regulation (elevation) of CRP

6) Confidence 0.18 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826745 Disease Relevance 0.53 Pain Relevance 0

Following treatment the increased level of CRP significantly decreased whereas AGP serum level remained unchanged.

Negative_regulation (decreased) of Positive_regulation (increased) of CRP

7) Confidence 0.13 Published 1994 Journal Z Rheumatol Section Abstract Doc Link 8023589 Disease Relevance 0.39 Pain Relevance 0.39

Interestingly, there also was a significant IDI in the comparison of model 4 with models 2 and 3, suggesting that the inclusion of both CPC and hsCRP improved discrimination over the inclusion of either CPC alone or hsCRP alone.

Negative_regulation (improved) of Positive_regulation (inclusion) of hsCRP

8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901328 Disease Relevance 0.33 Pain Relevance 0

RESULTS: After treatment, CD86 expression on DC, the stimulating capacity of DC as well as levels of IFN-gamma and CRP were lowered in both groups (P < 0.05 or P < 0.01), but the changes were much more significant in the treated group than those in the control group.

Negative_regulation (lowered) of Positive_regulation (levels) of CRP in CD86

9) Confidence 0.04 Published 2005 Journal Chin J Integr Med Section Body Doc Link 16417775 Disease Relevance 0.12 Pain Relevance 0

They also presented with a lower CRP concentration on the second day after the procedure (p < 0.0001 for all parameters).

Negative_regulation (presented) of Positive_regulation (concentration) of CRP

10) Confidence 0.03 Published 2007 Journal Cardiovasc Intervent Radiol Section Abstract Doc Link PMC2700241 Disease Relevance 0.38 Pain Relevance 0

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