INT55824

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.56
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gabrd)
Anatomy Link Frequency
TMJ 2
cortex 2
Gabrd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Snapping jaw 9 100.00 Very High Very High Very High
central sensitization 3 100.00 Very High Very High Very High
analgesia 3 99.40 Very High Very High Very High
gABA 17 97.62 Very High Very High Very High
Pain 6 94.88 High High
Analgesic 5 92.08 High High
antagonist 9 91.36 High High
nMDA receptor antagonist 1 80.72 Quite High
antinociception 8 77.96 Quite High
Glutamate 9 77.52 Quite High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 9 100.00 Very High Very High Very High
Anxiety Disorder 4 99.44 Very High Very High Very High
Nociception 4 99.16 Very High Very High Very High
Pain 4 94.88 High High
Hyperalgesia 1 76.88 Quite High
Epilepsy 1 72.80 Quite High
Low Back Pain 1 62.64 Quite High
Injury 1 53.04 Quite High
Generalized Anxiety Disorder 7 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus we conclude that pentobarbitone, but not propofol, produced pre-emptive analgesia in this model, presumably by suppressing noxious stimulation-induced central sensitization via activation of GABAA receptors.
Negative_regulation (suppressing) of Positive_regulation (activation) of GABAA associated with central sensitization and analgesia
1) Confidence 0.59 Published 1994 Journal Br J Anaesth Section Abstract Doc Link 8024913 Disease Relevance 0.39 Pain Relevance 0.87
[K+]o elevations were recorded in the entorhinal cortex during the ictal discharge (peak values = 13.9 +/- 0.9 mM) and the synchronous GABA-mediated potentials (peak values = 4.2 +/- 0.1 mM); the latter increases were presumably attributable to postsynaptic GABAa-receptor activation because they were abolished by DAGO or BMI.
Negative_regulation (abolished) of Positive_regulation (activation) of GABAa-receptor in cortex associated with gaba
2) Confidence 0.38 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8656285 Disease Relevance 0.07 Pain Relevance 0.66
In the previous report, we had shown that blockade and enhancement of GABAA receptors in the DMH of rats increased or decreased the level of anxiety, respectively, as measured by the elevated plus-maze test.
Negative_regulation (decreased) of Positive_regulation (enhancement) of GABAA associated with anxiety disorder
3) Confidence 0.36 Published 1993 Journal Brain Res. Section Abstract Doc Link 8293298 Disease Relevance 0.26 Pain Relevance 0.04
Our results suggest that activation of peripheral GABAA receptors located within the TMJ region could act to decrease the transmission of nociceptive information.
Negative_regulation (decrease) of Positive_regulation (activation) of GABAA in TMJ associated with nociception and snapping jaw
4) Confidence 0.31 Published 1999 Journal J. Neurophysiol. Section Abstract Doc Link 10200231 Disease Relevance 0.78 Pain Relevance 1.09
Both glycine- and GABAA receptor-mediated sIPSCs (GABAA-R sIPSCs) were present and were blocked by 1 ?
Negative_regulation (blocked) of Positive_regulation (mediated) of GABAA
5) Confidence 0.08 Published 2008 Journal Mol Pain Section Body Doc Link PMC2430948 Disease Relevance 0.06 Pain Relevance 0.22

General Comments

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