INT55837

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Context Info
Confidence 0.20
First Reported 1994
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.52
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PHB2) nucleus (PHB2) plasma membrane (HLA-B)
cytoplasm (PHB2)
Anatomy Link Frequency
T cell 1
HLA-B (Homo sapiens)
PHB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 26 100.00 Very High Very High Very High
spinal inflammation 14 99.54 Very High Very High Very High
cytokine 28 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chlamydia Infection 176 100.00 Very High Very High Very High
Seronegative Spondarthritis 21 100.00 Very High Very High Very High
Low Back Pain 14 99.54 Very High Very High Very High
Spondylarthropathies 7 99.52 Very High Very High Very High
Targeted Disruption 1 96.80 Very High Very High Very High
Infection 20 90.40 High High
Disease 17 88.76 High High
Arthritis 5 67.28 Quite High
Epstein-barr Virus 36 48.96 Quite Low
Rheumatoid Arthritis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both ankylosing spondylitis (AS) and reactive arthritis (ReA) are strongly associated with HLA-B27 although the mechanism for this association is still unknown.
HLA-B27 Binding (associated) of ReA associated with seronegative spondarthritis, spinal inflammation and arthritis
1) Confidence 0.20 Published 1994 Journal Eur. J. Immunol. Section Abstract Doc Link 8026527 Disease Relevance 0.72 Pain Relevance 0.54
Ankylosing spondylitis (AS), reactive arthritis (ReA) and other related spondyloarthropathies (SpAs) are characterized by a strong association with the major histocompatibility complex allele HLA-B27.
HLA-B27 Binding (association) of ReA associated with seronegative spondarthritis, spinal inflammation and arthritis
2) Confidence 0.18 Published 1998 Journal Mol Med Today Section Abstract Doc Link 9866824 Disease Relevance 0.79 Pain Relevance 0.44
Four of six HLA-B27+ Ct-ReA patients had specific synovial T cell binding to at least one HLA-B27/Chlamydia peptide tetramer.
HLA-B27/Chlamydia Binding (binding) of ReA in T cell associated with chlamydia infection
3) Confidence 0.03 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064864 Disease Relevance 1.04 Pain Relevance 0.08
Chlamydia-triggered reactive arthritis (Ct-ReA) is strongly associated with HLA-B27 like other spondylarthropathies, and especially ankylosing spondylitis [1,2].
HLA-B27 Binding (associated) of ReA associated with seronegative spondarthritis, spinal inflammation, spondylarthropathies, chlamydia infection and arthritis
4) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064864 Disease Relevance 0.98 Pain Relevance 0.31

General Comments

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