INT55853

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Context Info
Confidence 0.61
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.50
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
plasma 6
blood 6
anterior 2
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 18 99.84 Very High Very High Very High
qutenza 90 96.72 Very High Very High Very High
antagonist 26 88.36 High High
opioid receptor 1 76.56 Quite High
mu opioid receptor 1 75.00 Quite High
Endogenous opioid 1 65.88 Quite High
Opioid 1 56.08 Quite High
medulla 19 50.04 Quite High
dorsal root ganglion 44 36.36 Quite Low
anesthesia 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Reprotox - General 2 144 99.84 Very High Very High Very High
Pressure And Volume Under Development 46 99.84 Very High Very High Very High
Headache 18 99.84 Very High Very High Very High
Nerve Degeneration 6 98.92 Very High Very High Very High
Diabetes Mellitus 248 98.86 Very High Very High Very High
Volume Depletion And Dehydration 1 96.52 Very High Very High Very High
Congenital Anomalies 24 95.80 Very High Very High Very High
Hyperglycemia 28 92.48 High High
Stress 33 92.24 High High
Cardiovascular Disease 31 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, in anaesthetized rats, diltiazem inhibited ET-1-induced decreases in renal blood flow and increased renal accumulation of IR-ET-1.
Positive_regulation (increased) of Positive_regulation (accumulation) of IR-ET-1 in blood
1) Confidence 0.61 Published 1994 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 8027928 Disease Relevance 0.08 Pain Relevance 0
Naltrexone injection induced a significant elevation of ET-1 plasma concentration in both, dehydrated and control animals. (2) The content of irET-1 in anterior and intermediate lobes of the pituitary in dehydrated rats was markedly higher than in control group. (3) Naltrexone injection caused a rapid and significant reduction irET-1 within the anterior, intermediate and posterior lobes in dehydrated and control animals.
Positive_regulation (induced) of Positive_regulation (elevation) of ET-1 in anterior
2) Confidence 0.50 Published 1997 Journal Regul. Pept. Section Abstract Doc Link 9178351 Disease Relevance 0.10 Pain Relevance 0.20
Cells were then washed with DMEM, 10 mM HEPES, 0.5% BSA, 10 mM LiCl, and finally stimulated with buffer or increasing concentrations of ET-1 (10 pM to 100 nM) for 60 min at 37°C.
Positive_regulation (stimulated) of Positive_regulation (increasing) of ET-1
3) Confidence 0.46 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0
To analyse the role of PKC activation in ET-1-mediated potentiation of TRPV1, we tested the effect of the PKC inhibitor BIM X on the potentiation of capsaicin-induced TRPV1 currents in response to ET-1.
Positive_regulation (activation) of Positive_regulation (potentiation) of ET-1-mediated associated with qutenza
4) Confidence 0.46 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0.38
Since in the present study both ET-1 and NOS activation exhibit a similar course in 28-days diabetic rats, we speculate that NOS stimulation could be due to activation of ETB receptors via elevated ET-1 mechanisms.
Positive_regulation (activation) of Positive_regulation (elevated) of ET-1 associated with diabetes mellitus
5) Confidence 0.43 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.99 Pain Relevance 0.03
We conclude that blockade of the ET(A) receptor prevents the development of salt sensitive hypertension induced by sensory nerve degeneration, indicating that activation of the ET(A) receptor by increased plasma ET-1 level contributes to elevation of blood pressure in this model.
Positive_regulation (contributes) of Positive_regulation (increased) of ET-1 in blood associated with pressure and volume under development and nerve degeneration
6) Confidence 0.32 Published 2002 Journal Hypertension Section Abstract Doc Link 11882629 Disease Relevance 0.54 Pain Relevance 0.21
We conclude that blockade of the ET(A) receptor prevents the development of salt sensitive hypertension induced by sensory nerve degeneration, indicating that activation of the ET(A) receptor by increased plasma ET-1 level contributes to elevation of blood pressure in this model.
Positive_regulation (increased) of Positive_regulation (increased) of ET-1 in blood associated with pressure and volume under development and nerve degeneration
7) Confidence 0.32 Published 2002 Journal Hypertension Section Abstract Doc Link 11882629 Disease Relevance 0.54 Pain Relevance 0.21
The tone of the coronary arteries is critically dependent on an activation of ET receptors and an increased ET-1 associates with a proportional decrease in NO accompanying coronary endothelial dysfunction.46 Vascular abnormalities resulting from over-expression of endothelin receptor, leptin, and NOX and stress contribute to an increased risk of CVD (cardiovascular disease).
Positive_regulation (dependent) of Positive_regulation (activation) of ET-1 associated with stress, cardiovascular disease and congenital anomalies
8) Confidence 0.29 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.99 Pain Relevance 0.04
The tone of the coronary arteries is critically dependent on an activation of ET receptors and an increased ET-1 associates with a proportional decrease in NO accompanying coronary endothelial dysfunction.46 Vascular abnormalities resulting from over-expression of endothelin receptor, leptin, and NOX and stress contribute to an increased risk of CVD (cardiovascular disease).
Positive_regulation (activation) of Positive_regulation (increased) of ET-1 associated with stress, cardiovascular disease and congenital anomalies
9) Confidence 0.29 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.99 Pain Relevance 0.04
Patients with ED showed elevated levels of ET-1 in plasma compared to healthy adults.
Positive_regulation (elevated) of Positive_regulation (levels) of ET-1 in plasma associated with reprotox - general 2
10) Confidence 0.21 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684375 Disease Relevance 1.18 Pain Relevance 0
Vasopressin also induces endothelin-1 synthesis in endothelial cells, suggesting a role as a mediator of elevated plasma endothelin-1 in migraine.
Positive_regulation (mediator) of Positive_regulation (elevated) of endothelin-1 in plasma associated with migraine
11) Confidence 0.21 Published 1999 Journal Neuroreport Section Abstract Doc Link 10203347 Disease Relevance 0.52 Pain Relevance 0.52
These data suggest that vasopressin may act as a peripheral mediator of increased plasma endothelin-1 in migraine.
Positive_regulation (mediator) of Positive_regulation (increased) of endothelin-1 in plasma associated with migraine
12) Confidence 0.21 Published 1999 Journal Neuroreport Section Abstract Doc Link 10203347 Disease Relevance 0.57 Pain Relevance 0.57

General Comments

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