INT5586

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Context Info
Confidence 0.48
First Reported 1991
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 47
Total Number 51
Disease Relevance 12.70
Pain Relevance 21.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
brain 4
dorsal horn 4
neurons 4
nucleus 2
central nervous system 2
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 22 100.00 Very High Very High Very High
orphanin 14 100.00 Very High Very High Very High
lumbar region 1 100.00 Very High Very High Very High
intrathecal 37 99.98 Very High Very High Very High
Opioid 13 99.96 Very High Very High Very High
mu opioid receptor 10 99.90 Very High Very High Very High
Morphine 81 99.84 Very High Very High Very High
agonist 18 99.78 Very High Very High Very High
tolerance 15 99.78 Very High Very High Very High
ketamine 8 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myocardial Infarction 26 99.92 Very High Very High Very High
Neuroblastoma 1 99.52 Very High Very High Very High
Diuresis 1 99.40 Very High Very High Very High
Urological Neuroanatomy 41 99.36 Very High Very High Very High
Death 12 99.24 Very High Very High Very High
Nociception 93 99.04 Very High Very High Very High
Generalized Anxiety Disorder 4 98.96 Very High Very High Very High
Pain 238 98.88 Very High Very High Very High
Cognitive Disorder 3 98.24 Very High Very High Very High
Glioma 2 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, this study has demonstrated that c-Fos-ir in the PVN with an anatomical resolution can be semiquantitatively measured after immunohistochemistry using an image analysis system, and that increased c-fos mRNA in the PVN 1 hr after the AA treatment is associated with no changes of the CRF mRNA expression.
c-fos mRNA Binding (associated) of in PVN
1) Confidence 0.48 Published 2007 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 17514764 Disease Relevance 0 Pain Relevance 0.12
Glucocorticoid effects on Fos immunoreactivity and NADPH-diaphorase histochemical staining following spinal cord injury.
Fos Binding (immunoreactivity) of in spinal cord associated with pain and spinal cord
2) Confidence 0.37 Published 2001 Journal Brain Res. Section Title Doc Link 11532430 Disease Relevance 0.54 Pain Relevance 0.60
Double labeling with Fos and arginine vasopressin, oxytocin, or tyrosine hydroxylase antibodies was also performed.
Fos Binding (labeling) of
3) Confidence 0.37 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 7860779 Disease Relevance 0.08 Pain Relevance 0.18
Fos, a protein encoded by Fos pro-oncogene, was used as a biomarker for neuronal activation in response to noxious stimuli such as colorectal distension or inflammation.30,32,33 In intestinal epithelium, Fos also served as marker of mast cell or inflammatory cell activation.34,35
Fos Binding (oncogene) of in intestinal epithelium associated with inflammation
4) Confidence 0.37 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912124 Disease Relevance 0.26 Pain Relevance 0.33
Meanwhile, most of the Fos-IR neurons were observed in laminae I and II with a few in laminae III and IV and some in laminae V and VI of the dorsal horn (Fig. 2A), suggesting most of them were nociceptive neurons.
Fos Binding (most) of in dorsal horn associated with nociception and dorsal horn
5) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.09 Pain Relevance 0.62
SNL-induced Fos expression was restricted to the neuronal population as the ratio of Fos positive NeuN-IR cells to Fos-IR did not vary too much among different groups nor at different time points.
Fos Binding (ratio) of in neuronal associated with spinal nerve ligature
6) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.18 Pain Relevance 0.62
The differences in c-Fos immunoreactivity induced by changing the distension patterns suggested interactions between groups of vagal and splanchnic afferents.
c-Fos Binding (interactions) of
7) Confidence 0.36 Published 2004 Journal Exp Brain Res Section Abstract Doc Link 15252702 Disease Relevance 0.19 Pain Relevance 0.21
Corticotropin-releasing factor- and methionine-enkephakin-immunoreactive neurons displayed c-Fos immunoreactivity in naive rats after naloxone injection, whereas only enkephalinergic neurons were found to be c-Fos positive in morphine-dependent rats after naloxone injection.
c-Fos Binding (immunoreactivity) of in neurons associated with narcan and morphine
8) Confidence 0.36 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12956728 Disease Relevance 0 Pain Relevance 1.11
We also evaluated c-Fos immunoreactivity in those areas of the brain which have been shown to exhibit altered c-Fos expression upon N/OFQ administration.
c-Fos Binding (immunoreactivity) of in brain
9) Confidence 0.36 Published 2000 Journal Brain Res. Section Abstract Doc Link 10973597 Disease Relevance 0 Pain Relevance 0.57
However, under the present experimental conditions, c-fos does not seem to be associated with the upregulation of GAD mRNA induced by 5-HT.
c-fos Binding (associated) of associated with generalized anxiety disorder
10) Confidence 0.36 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12963037 Disease Relevance 0.31 Pain Relevance 0.52
Their brains were prepared for immunocytochemistry and stained with FosB and c-Fos antibodies.
c-Fos Binding (stained) of in brains
11) Confidence 0.36 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15899256 Disease Relevance 0 Pain Relevance 0.09
We investigate the linkage between the transcriptional factor, c-fos, and expression of proenkephalin in rat C6 glioma cells.
c-fos Binding (linkage) of associated with glioma
12) Confidence 0.36 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1312200 Disease Relevance 0.17 Pain Relevance 0.08
Correlation analysis revealed the positive association between c-fos- and p-ERK-immunoreactive nuclei numbers in the DRG, lumbosacral dorsal horn, and ACC.
c-fos Binding (association) of in dorsal horn associated with dorsal horn and anterior cingulate cortex
13) Confidence 0.36 Published 2009 Journal J. Mol. Neurosci. Section Abstract Doc Link 18649147 Disease Relevance 0.50 Pain Relevance 0.56
We then determined the level of c-Fos immunoreactivity in regions throughout the brain.
c-Fos Spec (determined) Binding (level) of in brain
14) Confidence 0.36 Published 2009 Journal Neuroscience Section Abstract Doc Link 19422884 Disease Relevance 0.07 Pain Relevance 0.50
Double labeling for CTb and c-Fos revealed significant recruitment of PVT projecting MDH neurons during extinction expression.
c-Fos Binding (labeling) of in PVT associated with thalamus
15) Confidence 0.36 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20962231 Disease Relevance 0.08 Pain Relevance 0.48
JunB was induced in the same regions of the caudate-putamen as found for c-Fos, but was not induced in the nucleus accumbens or thalamus.
c-Fos Binding (found) of in caudate-putamen associated with nucleus accumbens and thalamus
16) Confidence 0.36 Published 1995 Journal Brain Res. Section Abstract Doc Link 8548308 Disease Relevance 0 Pain Relevance 0.48
By combining c-fos (radioactive) in situ hybridization histochemistry with nonradioactive in situ hybridization histochemistry for mRNAs encoding other striatal markers [preprotachykinin (substance P), proenkephalin, and D1 and D2 receptors], we have identified the cellular phenotype of striatal neurons activated by acute administration of cocaine to P8, P15, P28, and adult rats.
c-fos Binding (combining) of in neurons associated with cocaine and substance p
17) Confidence 0.36 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7534774 Disease Relevance 0 Pain Relevance 0.30
Immunocytochemical methods were used to localize the protein product of the immediate-early gene, c-fos, in male rats after exposure to, or direct physical interaction with, oestrous females.
c-fos Binding (interaction) of
18) Confidence 0.36 Published 1992 Journal Neuroscience Section Abstract Doc Link 1436507 Disease Relevance 0.16 Pain Relevance 0.18
In the paraventricular n. of the thalamus formalin induced higher c-Fos than control in both sexes; when formalin treatment was carried out in presence of essential oil, c-Fos further increased in males, but remained at control levels in females.
c-Fos Binding (remained) of in thalamus associated with thalamus
19) Confidence 0.36 Published 2002 Journal Behav. Brain Res. Section Abstract Doc Link 12385797 Disease Relevance 0.07 Pain Relevance 0.29
The aim of this study was to investigate NADPH-d and c-Fos reactivity in the pedunculopontine tegmental nucleus following noxious peripheral stimulation.
Fos Binding (reactivity) of in nucleus
20) Confidence 0.36 Published 2004 Journal Neuroreport Section Abstract Doc Link 15094496 Disease Relevance 0.19 Pain Relevance 0.20

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