INT5587

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Context Info
Confidence 0.62
First Reported 1990
Last Reported 2010
Negated 32
Speculated 20
Reported most in Abstract
Documents 191
Total Number 211
Disease Relevance 40.81
Pain Relevance 99.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
spinal cord 19
brain 15
nucleus 12
neurons 9
hypothalamus 8
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 272 100.00 Very High Very High Very High
Morphine 260 100.00 Very High Very High Very High
cocaine 257 100.00 Very High Very High Very High
Pain 193 100.00 Very High Very High Very High
withdrawal 129 100.00 Very High Very High Very High
Hippocampus 94 100.00 Very High Very High Very High
amygdala 80 100.00 Very High Very High Very High
Enkephalin 63 100.00 Very High Very High Very High
narcan 63 100.00 Very High Very High Very High
agonist 62 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 150 100.00 Very High Very High Very High
Nociception 90 100.00 Very High Very High Very High
Rheumatoid Arthritis 27 100.00 Very High Very High Very High
Aids-related Complex 12 100.00 Very High Very High Very High
Stress 193 99.90 Very High Very High Very High
Brain Injury 12 99.82 Very High Very High Very High
Glioma 8 99.72 Very High Very High Very High
Spinal Cord Injury 6 99.72 Very High Very High Very High
Frailty 18 99.70 Very High Very High Very High
Neuropathic Pain 87 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although hypoxia in sham-injured rats did not by itself alter c-fos mRNA levels, it did significantly potentiate the TBI-induced changes in c-fos mRNA in all three brain regions.
Regulation (changes) of c-fos mRNA in brain associated with hypoxia and brain injury
1) Confidence 0.62 Published 1997 Journal Neuroreport Section Abstract Doc Link 9080414 Disease Relevance 0.93 Pain Relevance 0.22
Although hypoxia in sham-injured rats did not by itself alter c-fos mRNA levels, it did significantly potentiate the TBI-induced changes in c-fos mRNA in all three brain regions.
Neg (not) Regulation (alter) of c-fos mRNA in brain associated with hypoxia and brain injury
2) Confidence 0.62 Published 1997 Journal Neuroreport Section Abstract Doc Link 9080414 Disease Relevance 0.95 Pain Relevance 0.22
We examined the effects of naloxone (2 mg/kg) on c-fos mRNA levels in brains of infant and adult rats following repeated treatment with morphine (20 mg/kg, once daily for 5 days).
Spec (examined) Regulation (effects) of c-fos mRNA in brains associated with narcan and morphine
3) Confidence 0.62 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12499582 Disease Relevance 0.11 Pain Relevance 0.64
Glucocorticoid-mediated down regulation of c-fos mRNA in C6 glioma cells: lack of correlation with proenkephalin mRNA.
Regulation (regulation) of c-fos mRNA associated with enkephalin and glioma
4) Confidence 0.60 Published 1992 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 1312200 Disease Relevance 0.19 Pain Relevance 0.19
In the rat hippocampus, jun, c-fos, and fos-related antigen immunoreactivity, AP-1 DNA binding, and opioid peptide gene expression were examined after kainate treatment to determine whether the induction and DNA binding of AP-1 transcription factors are correlated with the expression of the opioid peptide genes.
Regulation (immunoreactivity) of c-fos in hippocampus associated with hippocampus and opioid
5) Confidence 0.60 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8417141 Disease Relevance 0 Pain Relevance 0.38
These data indicate that (1) c-fos, zif/268 and preprodynorphin mRNAs are differentially regulated in dorsal striatum, (2) behavioral tolerance results from chronic binges with 10 and 20 mg/kg cocaine and (3) the preprodynorphin genomic response exhibits tolerance to chronic high dose, but not low dose, cocaine binges.
Regulation (regulated) of c-fos in dorsal associated with tolerance and cocaine
6) Confidence 0.60 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7609608 Disease Relevance 0 Pain Relevance 0.38
Intra-amygdalar injection of DAMGO: effects on c-Fos levels in brain sites associated with feeding behavior.
Regulation (effects) of c-Fos in brain
7) Confidence 0.60 Published 2004 Journal Brain Res. Section Title Doc Link 15223361 Disease Relevance 0 Pain Relevance 0.71
However, the response of preproenkephalin, c-fos and zif/268 mRNAs to such a dosing regimen is unknown.
Regulation (response) of c-fos
8) Confidence 0.60 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7609608 Disease Relevance 0 Pain Relevance 0.26
In conclusion, persistent pain had different effects on c-Fos in the hippocampal subfields, depending on the time after treatment and the sex of the subject.
Regulation (effects) of c-Fos associated with pain and lasting pain
9) Confidence 0.60 Published 1999 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 10593203 Disease Relevance 0.24 Pain Relevance 0.27
On the other hand, there was little effect of MK-801 administration on Zif/268 and c-Fos immunoreactivity in the nucleus proprius and deep lamina V of the trigeminal nucleus caudalis, while most neurons expressing Zif/268 or c-Fos in these two regions were labeled by NR1.
Regulation (immunoreactivity) of c-Fos in nucleus associated with nmda receptor
10) Confidence 0.60 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 14596893 Disease Relevance 0.15 Pain Relevance 0.46
We have applied in situ hybridization histochemistry, Northern analysis, and immunocytochemistry to study the regulation of the immediate-early gene (IEG) c-fos, c-jun, and junB mRNAs and the respective proteins in the rat adrenal medulla.
Regulation (regulation) of c-fos in adrenal medulla associated with medulla
11) Confidence 0.60 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.26
Neuronal regulation of c-fos, c-jun, and junB immediate-early genes in rat adrenal medulla.
Regulation (regulation) of c-fos in adrenal medulla associated with medulla and qutenza
12) Confidence 0.60 Published 1995 Journal J. Neurosci. Section Title Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.44
Retinoic acid regulation of mu opioid receptor and c-fos mRNAs and AP-1 DNA binding in SH-SY5Y neuroblastoma cells.
Regulation (regulation) of c-fos in SH-SY5Y associated with neuroblastoma and mu opioid receptor
13) Confidence 0.60 Published 2002 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 11869806 Disease Relevance 0.65 Pain Relevance 0.42
In search for the underlying neuronal mechanisms we investigated the influence of stress on morphine-induced c-fos expression in the brain, and, vice versa, the influence of morphine application on the brain's c-fos response to stress.
Regulation (response) of c-fos in brain associated with stress and morphine
14) Confidence 0.60 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12225868 Disease Relevance 0.69 Pain Relevance 0.48
Induction of c-fos immunoreactivity in tyrosine hydroxylase and phenylethanolamine-N-methyltransferase immunoreactive neurons of the medulla oblongata of the rat after phosphate-buffered saline load in the urethane-anaesthetized rat.
Regulation (immunoreactivity) of c-fos in neurons associated with medulla and anesthesia
15) Confidence 0.60 Published 1993 Journal Brain Res. Section Title Doc Link 8095432 Disease Relevance 0 Pain Relevance 0.29
Effects of cocaine on c-fos and preprodynorphin mRNA levels in intact and ovariectomized Fischer rats.
Regulation (Effects) of c-fos associated with cocaine
16) Confidence 0.60 Published 2002 Journal Brain Res. Bull. Section Title Doc Link 12128156 Disease Relevance 0 Pain Relevance 0.38
In this study we investigated the effects of cocaine on c-fos and mu-opioid receptor mRNA levels in primary cortical astrocyte cultures, using RT-PCR and quantitative solution hybridization assays.
Spec (investigated) Regulation (effects) of c-fos in astrocyte associated with opioid receptor and cocaine
17) Confidence 0.60 Published 2002 Journal Brain Res. Bull. Section Abstract Doc Link 12128154 Disease Relevance 0 Pain Relevance 0.67
The effect of [Phe(1)psi(CH(2)-NH)Gly(2)]-nociceptin(1-13)NH(2) on feeding and c-Fos immunoreactivity in selected brain sites.
Regulation (immunoreactivity) of c-Fos in brain associated with orphanin
18) Confidence 0.60 Published 2000 Journal Brain Res. Section Title Doc Link 10973597 Disease Relevance 0 Pain Relevance 0.56
Systemic administration of WIN-2 (1 or 10mg/kg, i.p.) or SR141716A (1mg/kg, i.v.) or topical corneal application of morphine sulfate did not affect Fos-LI produced by MO.
Neg (not) Regulation (affect) of Fos associated with morphine
19) Confidence 0.60 Published 2002 Journal Pain Section Abstract Doc Link 12406531 Disease Relevance 0 Pain Relevance 0.79
Cocaine (3 mg/kg) had no significant effect on c-fos.
Neg (no) Regulation (effect) of c-fos associated with cocaine
20) Confidence 0.60 Published 1994 Journal Neuroscience Section Abstract Doc Link 7520134 Disease Relevance 0 Pain Relevance 0.74

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