INT55874

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Context Info
Confidence 0.34
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 4.20
Pain Relevance 13.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
bars 1
Plasma 1
liver 1
embryonic kidney 1
respiratory 1
GPM6A (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 562 100.00 Very High Very High Very High
agonist 8 99.96 Very High Very High Very High
opioid receptor 127 99.84 Very High Very High Very High
methotrexate 3 99.54 Very High Very High Very High
vincristine 2 99.26 Very High Very High Very High
Lasting pain 1 97.28 Very High Very High Very High
depression 3 97.24 Very High Very High Very High
Opioid 22 97.00 Very High Very High Very High
Codeine 11 96.56 Very High Very High Very High
Analgesic 13 96.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cirrhosis 550 100.00 Very High Very High Very High
Vomiting 4 99.00 Very High Very High Very High
Hypoxia 1 97.84 Very High Very High Very High
Pain 11 97.28 Very High Very High Very High
Depression 1 97.24 Very High Very High Very High
Post-operative Nausea 2 95.88 Very High Very High Very High
Respiratory Failure 2 93.76 High High
Cancer 3 90.28 High High
Post Operative Pain 4 75.00 Quite High
Fibrosis 40 70.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preliminary data indicate that M6G is associated less than morphine with nausea and vomiting, causing 50% and 75% less nausea in postoperative and experimental settings, respectively.
M6G Binding (associated) of associated with vomiting and morphine
1) Confidence 0.34 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16717327 Disease Relevance 0.56 Pain Relevance 1.43
M6G binds to opioid receptors, and animal studies have demonstrated that M6G may be a more potent analgesic than morphine.
M6G Binding (binds) of associated with analgesic, opioid receptor and morphine
2) Confidence 0.30 Published 2003 Journal J Pain Symptom Manage Section Abstract Doc Link 12565191 Disease Relevance 0.07 Pain Relevance 1.25
There are various observations that M6G is associated with a reduction in the severity of side effects normally associated with opioid use, such as reduced postoperative nausea and vomiting (PONV) and reduced respiratory depression.
M6G Binding (associated) of in respiratory associated with post-operative nausea, depression, respiratory failure, vomiting and opioid
3) Confidence 0.28 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17869146 Disease Relevance 0.55 Pain Relevance 0.78
Moreover, the interaction of M6a and MOPr augments constitutive and agonist-dependent internalization as well as the recycling rate of mu-opioid receptors.
M6a Binding (interaction) of associated with mu opioid receptor, agonist and opioid receptor
4) Confidence 0.26 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17548356 Disease Relevance 0 Pain Relevance 0.77
Plasma samples were assayed following appropriate dilution, using a morphine specific antiserum and the results subtracted from those obtained with an antiserum which cross-reacts with both morphine and M6G.
M6G Binding (cross-reacts) of in Plasma associated with morphine
5) Confidence 0.23 Published 1994 Journal J Pharm Biomed Anal Section Abstract Doc Link 8031935 Disease Relevance 0 Pain Relevance 0.99
Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling.
M6a Binding (interacts) of associated with opioid receptor
6) Confidence 0.20 Published 2007 Journal J. Biol. Chem. Section Title Doc Link 17548356 Disease Relevance 0 Pain Relevance 0.63
Bioluminescence resonance energy transfer and co-immunoprecipitation experiments confirmed that M6a interacts agonist-independently with MOPr in human embryonic kidney 293 cells co-expressing MOPr and M6a.
M6a Binding (interacts) of in embryonic kidney associated with agonist and opioid receptor
7) Confidence 0.20 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17548356 Disease Relevance 0 Pain Relevance 0.60
M3G and M6G vary in their ability to interact with the opioid receptor effector system.
M6G Binding (interact) of associated with opioid receptor
8) Confidence 0.17 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10686401 Disease Relevance 0 Pain Relevance 0.99
In contrast, M3G and M6G formation by UGT2B7 exhibited atypical kinetics.
M6G Binding (formation) of
9) Confidence 0.08 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12920162 Disease Relevance 0 Pain Relevance 0.35
Thus, we have characterized the selectivity and kinetics of M3G and M6G formation by recombinant human UGTs.
M6G Binding (formation) of
10) Confidence 0.07 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12920162 Disease Relevance 0 Pain Relevance 0.34
The influence of the following was examined: Human serum albumin (HSA), alpha-1 acid glycoprotein (AAG), non-esterified fatty acids (NEFA); palmitic acid and oleic acid, pH, vincristine, methotrexate, 6-mercaptopurine and M6G. binding correlated with concentrations of albumin and alpha1 acid glycoprotein.
M6G Binding (binding) of associated with vincristine and methotrexate
11) Confidence 0.03 Published 2007 Journal J Pain Palliat Care Pharmacother Section Abstract Doc Link 18032310 Disease Relevance 0.17 Pain Relevance 0.74
However, the respective contribution of the gastrointestinal tract and the liver to the formation of the analgetically highly potent morphine-6-glucuronide (M6G) and the inactive morphine-3-glucuronide (M3G) is still debated.
M6G Binding (formation) of in liver associated with morphine
12) Confidence 0.02 Published 1993 Journal Drug Metab. Dispos. Section Abstract Doc Link 8095206 Disease Relevance 0 Pain Relevance 0.61
The pharmacokinetics and pharmacodynamics of M6G also seems to be related to A118G mutation of the human ?
M6G Binding (seems) of
13) Confidence 0.02 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376067 Disease Relevance 0.16 Pain Relevance 1.14
The apparent morphine K(M) for the formation of M3G was significantly different than the apparent K(M) for the formation of M6G.
M6G Binding (formation) of associated with morphine
14) Confidence 0.01 Published 1999 Journal Biol. Neonate Section Abstract Doc Link 10567765 Disease Relevance 0 Pain Relevance 0.96
In addition, co-incubation with polyinosinic acid, a known blocker for the scavenger receptor class A (29), strongly reduced the binding of 15dPGJ2-M6PHSA to the cells.
M6PHSA Binding (binding) of
15) Confidence 0.01 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.56 Pain Relevance 0
The first carrier M6PHSA, which is substituted with sugar groups as homing devices, binds to the M6P/IGFII receptor present on activated HSC (4).
M6PHSA Binding (binds) of associated with cirrhosis
16) Confidence 0.01 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.56 Pain Relevance 0
To assess the cellular binding of the conjugates as described (7), 15dPGJ2-M6PHSA and 15dPGJ2-pPBHSA were radioactively labelled with 125I (26).
M6PHSA Binding (binding) of
17) Confidence 0.01 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.53 Pain Relevance 0
The aim of this study was therefore to chemically couple 15dPGJ2 to two different HSC-selective drug carriers, i.e., M6PHSA and pPBHSA, and to compare their effectiveness by studying the uptake and pharmacological effects within the target cells.


M6PHSA Binding (couple) of associated with cirrhosis
18) Confidence 0.01 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.44 Pain Relevance 0.06
Fig. 1Binding of the conjugates 125I–15dPGJ2-M6PHSA (black bars) and 125I–15dPGJ2-pPBHSA (white bars) to cultures of activated rat HSC.
M6PHSA Binding (1Binding) of in bars associated with cirrhosis
19) Confidence 0.00 Published 2007 Journal Pharm Res Section Body Doc Link PMC1915609 Disease Relevance 0.53 Pain Relevance 0.09
It appears that the 6D6 antibody displays a high affinity for M6G (50% displacement point?
M6G Binding (affinity) of
20) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808358 Disease Relevance 0.06 Pain Relevance 0.99

General Comments

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