INT55878

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1994
Last Reported 2010
Negated 7
Speculated 7
Reported most in Body
Documents 34
Total Number 41
Disease Relevance 15.71
Pain Relevance 17.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL2) extracellular space (CCL2) aging (CCL2)
extracellular region (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)
Anatomy Link Frequency
plasma 8
neurons 8
monocyte 5
microglial cells 4
blood 4
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 500 100.00 Very High Very High Very High
chemokine 295 100.00 Very High Very High Very High
cytokine 280 100.00 Very High Very High Very High
acular 7 100.00 Very High Very High Very High
Peripheral nerve injury 3 100.00 Very High Very High Very High
alcohol 10 99.98 Very High Very High Very High
lidocaine 6 99.90 Very High Very High Very High
Chronic pancreatitis 2 99.84 Very High Very High Very High
antidepressant 10 99.80 Very High Very High Very High
MU agonist 10 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 73 100.00 Very High Very High Very High
Nervous System Injury 13 100.00 Very High Very High Very High
Pancreatitis 3 99.84 Very High Very High Very High
Hyperhomocysteinemia 6 99.62 Very High Very High Very High
Neuropathic Pain 2 99.56 Very High Very High Very High
Rheumatoid Arthritis 124 99.48 Very High Very High Very High
INFLAMMATION 353 99.36 Very High Very High Very High
Acute Coronary Syndrome 32 99.32 Very High Very High Very High
Pre-eclampsia 15 99.08 Very High Very High Very High
Arthritis 11 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study was to explore the influence of morphine on CCL2 expression by human neurons.
Regulation (influence) of Gene_expression (expression) of CCL2 in neurons associated with morphine
1) Confidence 0.62 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0 Pain Relevance 1.18
However, one potential implication of the specificity for neurons of morphine's stimulatory effect on CCL2 production is that opiates may increase recruitment of inflammatory cells within the CNS via their effect on neurons.
Regulation (effect) of Gene_expression (production) of CCL2 in neurons associated with inflammation, central nervous system, opiate and morphine
2) Confidence 0.62 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0.39 Pain Relevance 1.12
In this study, the authors investigated whether eotaxin and MCP-1 expression and release in human airway smooth muscle cells could be modulated by an increase in intracellular cyclic adenosine monophosphate (cAMP) concentration.
Regulation (modulated) of Gene_expression (expression) of MCP-1 in smooth muscle cells associated with adenocard
3) Confidence 0.56 Published 2003 Journal Eur. Respir. J. Section Abstract Doc Link 12952251 Disease Relevance 0.28 Pain Relevance 0.22
The effects of LY294002 (LY29) and wortmannin (WM), inhibitors of phosphatidylinositol 3-kinase (PI3K), on monocyte chemoattractant protein-1 (MCP-1) expression by human umbilical vein endothelial cells were investigated.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of monocyte chemoattractant protein-1 in endothelial cells
4) Confidence 0.54 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 14960322 Disease Relevance 0 Pain Relevance 0
-FNA significantly abrogated morphine's effect on neuronal CCL2 production, the blockade was only partial.
Regulation (effect) of Gene_expression (production) of CCL2 in neuronal associated with morphine
5) Confidence 0.54 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0.08 Pain Relevance 1.20
However, they found as did we, that exposure of astrocytes to morphine alone had no significant effect on CCL2 production [25].
Neg (no) Regulation (effect) of Gene_expression (production) of CCL2 in astrocytes associated with morphine
6) Confidence 0.54 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0.09 Pain Relevance 1.18
circulating MCP-1 concentrations in IUGR neonates compared to AGA controls, as
Regulation (circulating) of Gene_expression (concentrations) of MCP-1
7) Confidence 0.45 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.24 Pain Relevance 0
not prove to have a significant effect on circulating MCP-1 concentrations in
Regulation (effect) of Gene_expression (concentrations) of MCP-1
8) Confidence 0.45 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.06 Pain Relevance 0
demonstrated significantly elevated MCP-1 concentrations in preeclamptic
Regulation (demonstrated) of Gene_expression (concentrations) of MCP-1
9) Confidence 0.45 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.42 Pain Relevance 0
and parity on plasma MCP-1 concentrations was not
Regulation (parity) of Gene_expression (concentrations) of MCP-1 in plasma
10) Confidence 0.45 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.15 Pain Relevance 0.17
based on the hypothesis that circulating concentrations of MCP-1 might differ
Spec (might) Regulation (differ) of Gene_expression (concentrations) of MCP-1
11) Confidence 0.45 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.19 Pain Relevance 0.13
Modulation by cAMP of IL-1beta-induced eotaxin and MCP-1 expression and release in human airway smooth muscle cells.
Regulation (Modulation) of Gene_expression (expression) of MCP-1 in smooth muscle cells
12) Confidence 0.41 Published 2003 Journal Eur. Respir. J. Section Title Doc Link 12952251 Disease Relevance 0.29 Pain Relevance 0.22
The effects of LY294002 (LY29) and wortmannin (WM), inhibitors of phosphatidylinositol 3-kinase (PI3K), on monocyte chemoattractant protein-1 (MCP-1) expression by human umbilical vein endothelial cells were investigated.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of MCP-1 in endothelial cells
13) Confidence 0.40 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 14960322 Disease Relevance 0 Pain Relevance 0
-FNA and assess its statistical significance, we compared the mean difference in morphine-exposed and control neuronal CCL2 production in the presence and absence of ?
Regulation (absence) of Gene_expression (production) of CCL2 in neuronal associated with morphine
14) Confidence 0.39 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0 Pain Relevance 0.65
Using concentrations of homocysteine that had inflammatory effects in vitro, and are in the range that may occur in patients with hyperhomocysteinemia [41], we found no effect on IL-6 or MCP-1 production in whole blood over 24 hours of incubation.
Neg (no) Regulation (effect) of Gene_expression (production) of MCP-1 in blood associated with inflammation and hyperhomocysteinemia
15) Confidence 0.34 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0.38 Pain Relevance 0.25
Neither 50 nor 100 ┬ÁM/L DL-homocysteine affected MCP-1 or IL-6 production significantly compared to saline (all P values > 0.07) (Figure 1a, b).
Neg (Neither) Regulation (affected) of Gene_expression (production) of MCP-1
16) Confidence 0.34 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0 Pain Relevance 0.07
In addition to IL-1b, other key inflammatory mediators, e.g., CXCL8 (IL-8), CCL2 (MCP-1) [42,49], and the synthesis of prostaglandins, by induction of COX-2 [49,50] are all up-regulated in response to withdrawal of P.
Regulation (regulated) of Gene_expression (synthesis) of MCP-1 associated with inflammatory mediators and withdrawal
17) Confidence 0.29 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775064 Disease Relevance 0.51 Pain Relevance 0.31
In addition to IL-1b, other key inflammatory mediators, e.g., CXCL8 (IL-8), CCL2 (MCP-1) [42,49], and the synthesis of prostaglandins, by induction of COX-2 [49,50] are all up-regulated in response to withdrawal of P.
Regulation (regulated) of Gene_expression (synthesis) of CCL2 associated with inflammatory mediators and withdrawal
18) Confidence 0.29 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775064 Disease Relevance 0.51 Pain Relevance 0.31
There was no correlation between the levels of MCP-1 in CSF and that in serum (r = ?
Neg (no) Regulation (correlation) of Gene_expression (levels) of MCP-1
19) Confidence 0.28 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.06 Pain Relevance 0.12
There was also no correlation between the levels of MCP-1 and IL-6 (r = ?
Neg (no) Regulation (correlation) of Gene_expression (levels) of MCP-1
20) Confidence 0.28 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.11 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox