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Context Info
Confidence 0.49
First Reported 1992
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.68
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
dorsal root 2
spinal cord 2
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 2 99.98 Very High Very High Very High
Morphine 6 99.02 Very High Very High Very High
Spinal cord 4 97.56 Very High Very High Very High
Dorsal horn 4 95.72 Very High Very High Very High
medulla 1 81.96 Quite High
antagonist 1 75.24 Quite High
nMDA receptor 2 75.00 Quite High
qutenza 3 73.68 Quite High
Pain 5 72.92 Quite High
Analgesic 1 71.84 Quite High
Disease Link Frequency Relevance Heat
Glioma 2 96.16 Very High Very High Very High
Injury 4 89.40 High High
Pain 4 72.92 Quite High
Temporomandibular Joint Disorders 1 65.04 Quite High
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of cells with dexamethasone resulted in a 10-fold decline in c-fos transcripts and a small increase in proenkephalin mRNA.
Positive_regulation (resulted) of Negative_regulation (decline) of c-fos associated with dexamethasone
1) Confidence 0.49 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1312200 Disease Relevance 0.17 Pain Relevance 0.10
The method of preparation generated a low level of c-fos-ir activity which was not significantly altered by low intensity (1.5 times threshold) dorsal root stimulation, but was significantly increased by high intensity (20 times threshold) stimulation.
Positive_regulation (generated) of Negative_regulation (level) of c-fos-ir in dorsal root
2) Confidence 0.46 Published 1998 Journal J. Neurosci. Methods Section Abstract Doc Link 9531466 Disease Relevance 0 Pain Relevance 0.24
Morphine given centrally (i.c.v.) or peripherally (i.v.) caused a marked dose-related reduction in Fos-like immunoreactivity (Fos-LI) in laminae I-II at the middle portions of subnucleus caudalis (mid-Vc) and at the subnucleus caudalis/upper cervical spinal cord (Vc/C2) transition.
Positive_regulation (caused) of Negative_regulation (reduction) of Fos in spinal cord associated with spinal cord and morphine
3) Confidence 0.45 Published 2000 Journal Pain Section Abstract Doc Link 10692604 Disease Relevance 0.51 Pain Relevance 1.08

General Comments

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