INT55880

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Context Info
Confidence 0.59
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 49
Total Number 50
Disease Relevance 22.37
Pain Relevance 18.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL2) extracellular space (CCL2) aging (CCL2)
extracellular region (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)
Anatomy Link Frequency
monocyte 22
endothelial cells 13
TAM 4
MG-63 4
microglia 4
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 427 100.00 Very High Very High Very High
chemokine 309 100.00 Very High Very High Very High
Morphine 155 100.00 Very High Very High Very High
acular 8 100.00 Very High Very High Very High
dexamethasone 31 99.98 Very High Very High Very High
lidocaine 12 99.98 Very High Very High Very High
Chronic pancreatitis 64 99.86 Very High Very High Very High
methotrexate 25 99.68 Very High Very High Very High
aspirin 27 99.46 Very High Very High Very High
Arthritis 171 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 524 100.00 Very High Very High Very High
Pancreatitis 65 99.86 Very High Very High Very High
Osteoporosis 63 99.60 Very High Very High Very High
Arthritis 196 99.42 Very High Very High Very High
Cancer 173 99.18 Very High Very High Very High
Cv Unclassified Under Development 17 99.06 Very High Very High Very High
Rheumatoid Arthritis 394 99.04 Very High Very High Very High
Influenza Virus Infection 15 99.02 Very High Very High Very High
Otitis Media 2 99.00 Very High Very High Very High
Primary Sclerosing Cholangitis 121 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lidocaine inhibited lipopolysaccharide-induced MCP-1 production as well as messenger RNA expression in a dose-dependent manner.
Negative_regulation (inhibited) of Gene_expression (production) of MCP-1 associated with lidocaine
1) Confidence 0.59 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14570645 Disease Relevance 0.40 Pain Relevance 0.71
Together, the findings indicate that in endothelial cells aspirin and PPAR-alpha activators reduce the high glucose-increased expression of MCP-1 by a mechanism that includes the inhibition of reactive oxygen species, and decrease of AP-1 and NF-kB activation.
Negative_regulation (reduce) of Gene_expression (expression) of MCP-1 in endothelial cells associated with aspirin
2) Confidence 0.56 Published 2006 Journal Vascul. Pharmacol. Section Abstract Doc Link 16600694 Disease Relevance 0.16 Pain Relevance 0.27
This raises the hypothesis that pitavastatin is able to block monocyte activation and migration by downregulation of CCL2 gene expression in CCL2-secreting cells.
Negative_regulation (downregulation) of Gene_expression (expression) of CCL2 in monocyte
3) Confidence 0.55 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2944780 Disease Relevance 0.13 Pain Relevance 0.08
This study shows that an increase in intracellular cyclic adenosine monophosphate concentration may decrease the interleukin-1beta-induced eotaxin and monocyte chemotactic protein-1 expression and production.
Spec (may) Negative_regulation (decrease) of Gene_expression (expression) of monocyte chemotactic protein-1 in monocyte associated with adenocard
4) Confidence 0.47 Published 2003 Journal Eur. Respir. J. Section Abstract Doc Link 12952251 Disease Relevance 0 Pain Relevance 0.23
Furthermore, treatment of human astrocytes with morphine has been shown by others to downregulate CCL2 mRNA and protein expression [6].
Negative_regulation (downregulate) of Gene_expression (expression) of CCL2 mRNA in astrocytes associated with morphine
5) Confidence 0.43 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0.09 Pain Relevance 1.29
knowledge, plasma MCP-1 concentrations in IUGR and AGA
Negative_regulation (knowledge) of Gene_expression (concentrations) of MCP-1 in plasma
6) Confidence 0.43 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.25 Pain Relevance 0.07
In contrast, exogenous corticosterone abolished the effects of ketorolac on IL-1beta-induced COX-2 and monocyte chemoattractant protein-1 gene expression in the cerebral endothelium.
Negative_regulation (abolished) of Gene_expression (expression) of monocyte chemoattractant protein-1 in endothelium associated with acular
7) Confidence 0.42 Published 2002 Journal Endocrinology Section Abstract Doc Link 12446609 Disease Relevance 0.09 Pain Relevance 0.92
The results showed that (i) aspirin, fenofibrate and clofibrate decrease significantly the MCP-1 expression and secretion in human endothelial cells; (ii) the high glucose up-regulated expression of MCP-1 in endothelial cells was significantly reduced by inhibitors of NF-kB and reactive oxygen species; (iii) all drugs notably decrease the level of the reactive oxygen species and activation of NF-kB and AP-1.
Negative_regulation (decrease) of Gene_expression (expression) of MCP-1 in endothelial cells associated with aspirin
8) Confidence 0.41 Published 2006 Journal Vascul. Pharmacol. Section Abstract Doc Link 16600694 Disease Relevance 0.41 Pain Relevance 0.34
The results showed that (i) aspirin, fenofibrate and clofibrate decrease significantly the MCP-1 expression and secretion in human endothelial cells; (ii) the high glucose up-regulated expression of MCP-1 in endothelial cells was significantly reduced by inhibitors of NF-kB and reactive oxygen species; (iii) all drugs notably decrease the level of the reactive oxygen species and activation of NF-kB and AP-1.
Negative_regulation (reduced) of Gene_expression (expression) of MCP-1 in endothelial cells associated with aspirin
9) Confidence 0.41 Published 2006 Journal Vascul. Pharmacol. Section Abstract Doc Link 16600694 Disease Relevance 0.38 Pain Relevance 0.33
The literature that links monocyte activation and differentiation to CCL2 and CCL2 to pitavastatin, show that CCL2 is an inducer of monocyte activation and migration [58] and that pitavastatin attenuates gene expression of CCL2 in smooth muscle and endothelial cells [59], [60].
Negative_regulation (attenuates) of Gene_expression (expression) of CCL2 in endothelial cells
10) Confidence 0.40 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2944780 Disease Relevance 0.14 Pain Relevance 0.09
Prostaglandin E2, known as an activator of the prostanoid receptors EP2 and EP4, which are positively coupled to adenylyl cyclase, also decreased the IL-1beta-induced eotaxin and MCP-1 production by 57+/-17 and 53+/-4%, respectively.
Negative_regulation (decreased) of Gene_expression (production) of MCP-1
11) Confidence 0.39 Published 2003 Journal Eur. Respir. J. Section Abstract Doc Link 12952251 Disease Relevance 0.19 Pain Relevance 0.22
Lidocaine attenuates monocyte chemoattractant protein-1 production and chemotaxis in human monocytes: possible mechanisms for its effect on inflammation.
Negative_regulation (attenuates) of Gene_expression (production) of monocyte chemoattractant protein-1 in monocytes associated with inflammation and lidocaine
12) Confidence 0.38 Published 2003 Journal Anesth. Analg. Section Title Doc Link 14570645 Disease Relevance 0.40 Pain Relevance 0.72
-FNA significantly abrogated morphine's effect on neuronal CCL2 production, the blockade was only partial.
Negative_regulation (abrogated) of Gene_expression (production) of CCL2 in neuronal associated with morphine
13) Confidence 0.38 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0.08 Pain Relevance 1.21
LY303511 (LY30), an inactive analogue of LY29, also inhibited MCP-1 expression.
Negative_regulation (inhibited) of Gene_expression (expression) of MCP-1
14) Confidence 0.37 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 14960322 Disease Relevance 0 Pain Relevance 0.08
At these concentrations, LY29, but not WM, significantly inhibited constitutive and IL-1beta-induced MCP-1 expression at both protein and mRNA levels.
Negative_regulation (inhibited) of Gene_expression (expression) of MCP-1
15) Confidence 0.37 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 14960322 Disease Relevance 0 Pain Relevance 0.07
-FNA and assess its statistical significance, we compared the mean difference in morphine-exposed and control neuronal CCL2 production in the presence and absence of ?
Negative_regulation (exposed) of Gene_expression (production) of CCL2 in neuronal associated with morphine
16) Confidence 0.37 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0 Pain Relevance 0.64
Aspirin and PPAR-alpha activators inhibit monocyte chemoattractant protein-1 expression induced by high glucose concentration in human endothelial cells.
Negative_regulation (inhibit) of Gene_expression (expression) of chemoattractant protein-1 in endothelial cells associated with aspirin
17) Confidence 0.36 Published 2006 Journal Vascul. Pharmacol. Section Title Doc Link 16600694 Disease Relevance 0.52 Pain Relevance 0.37
The ischemia-induced expression of ICAM-1 in HCEC, and the expression/release of IL-8 and MCP-1 in HCEC were abolished by the non-steroid anti-inflammatory drug, indomethacin (100-300 microM).
Negative_regulation (abolished) of Gene_expression (expression/release) of MCP-1 in HCEC associated with inflammation and ischemia
18) Confidence 0.35 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 1.13 Pain Relevance 0.57
LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism.
Negative_regulation (inhibits) of Gene_expression (expression) of monocyte chemoattractant protein-1 in monocyte
19) Confidence 0.33 Published 2004 Journal FEBS Lett. Section Title Doc Link 14960322 Disease Relevance 0 Pain Relevance 0.06
The experimental findings of the study suggested that EGCG inhibits oncostatin M-induced MCP-1/CCL2 synthesis in human osteoblastic and MG-63 cells by reducing c-Fos synthesis [31].
Negative_regulation (inhibits) of Gene_expression (synthesis) of MCP-1 in MG-63 associated with osteoporosis
20) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.83 Pain Relevance 0

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