INT55886

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Context Info
Confidence 0.57
First Reported 1994
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 47
Total Number 48
Disease Relevance 26.04
Pain Relevance 11.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
T cells 12
macrophage 2
lymph nodes 2
Liver 2
dendritic cells 2
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 757 100.00 Very High Very High Very High
Inflammation 713 100.00 Very High Very High Very High
Nerve growth factor 148 100.00 Very High Very High Very High
Crohn's disease 23 100.00 Very High Very High Very High
narcan 17 99.98 Very High Very High Very High
antagonist 101 99.80 Very High Very High Very High
agonist 36 99.60 Very High Very High Very High
tolerance 19 99.58 Very High Very High Very High
opioid receptor 2 99.58 Very High Very High Very High
qutenza 21 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 714 100.00 Very High Very High Very High
Disease 244 100.00 Very High Very High Very High
Targeted Disruption 104 100.00 Very High Very High Very High
Inflammatory Bowel Disease 45 100.00 Very High Very High Very High
Granuloma 36 100.00 Very High Very High Very High
Infection 123 99.78 Very High Very High Very High
Eosinophilia 43 99.76 Very High Very High Very High
Hyperplasia 77 99.62 Very High Very High Very High
Multiple Sclerosis 23 99.48 Very High Very High Very High
Eczema 337 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged N. brasiliensis infection, due to a deficiency in smooth muscle cell expression of IL-4R?
Negative_regulation (deficiency) of Gene_expression (expression) of IL-4 in smooth muscle cell associated with infection
1) Confidence 0.57 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.38 Pain Relevance 0.17
In addition, the ability of D. andersoni infestation to program specific CD4 T cell expression of IL-4 was significantly reduced during the second infestation.
Negative_regulation (reduced) of Gene_expression (expression) of IL-4 in T cell
2) Confidence 0.48 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.12 Pain Relevance 0
/lox mice as by day 10 PI in goblet cell hyperplasia was comparable to levels observed in IL-4R??
Negative_regulation (levels) of Gene_expression (observed) of IL-4 in goblet cell associated with hyperplasia
3) Confidence 0.41 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.69 Pain Relevance 0.03
At the cell level, the hexane fraction markedly inhibited beta-hexosaminidase release from RBL-2H3 mast cells and suppressed the expressions of mRNA interferon-gamma and interleukin-4 cytokines produced by T helper cells (type 1 and 2).
Negative_regulation (suppressed) of Gene_expression (expressions) of interleukin-4 in mast cells associated with cytokine
4) Confidence 0.41 Published 2009 Journal Arch. Pharm. Res. Section Abstract Doc Link 19557358 Disease Relevance 0.87 Pain Relevance 0.15
As such, our demonstration of significant inhibition of M3 expression in IL-4R?
Negative_regulation (inhibition) of Gene_expression (expression) of IL-4
5) Confidence 0.41 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.27 Pain Relevance 0.03
agonists have been shown to reduce IL4, IL5, and IL13 production from Tcells of mice with induced lung inflammation [38,49].
Negative_regulation (reduce) of Gene_expression (production) of IL4 in lung associated with inflammation, agonist and pneumonia
6) Confidence 0.36 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1781426 Disease Relevance 0.52 Pain Relevance 0.36
The acute and chronic treatment with the opioid receptor antagonist naloxone decreased the production of IL-4 by splenocytes of C57BL/6 and Balb/cJ mice, that present a Th1/Th2 dominance, respectively, immunized with the protein antigen KLH.
Negative_regulation (decreased) of Gene_expression (production) of IL-4 associated with antagonist, narcan and opioid receptor
7) Confidence 0.32 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11268404 Disease Relevance 0.07 Pain Relevance 0.78
In CD4 cells, PGJ2 and the TZD ciglitazone reduced IL4 production [35] and in EAE, the animal model of Multiple Sclerosis, PGJ2 blocked splenic T cell production of IL10 and IL4 [36].
Negative_regulation (reduced) of Gene_expression (production) of IL4 in T cell associated with multiple sclerosis
8) Confidence 0.31 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1781426 Disease Relevance 0.78 Pain Relevance 0.30
Our data also shows that the extract of IO suppressed the expression of IL-4 in mice.
Negative_regulation (suppressed) of Gene_expression (expression) of IL-4
9) Confidence 0.29 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840610 Disease Relevance 1.26 Pain Relevance 0.29
In murine splenic T cells, CD3-induced and CD3/CD28-induced IL-4 expression as well as CD30-induced IL-13 expression were also partly abrogated by SB203580 [44,46,67].
Negative_regulation (abrogated) of Gene_expression (expression) of IL-4 in T cells
10) Confidence 0.29 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.09
In addition, Th2 cells, through the production of IL-4, downmodulate Th1 differentiation and macrophage activation and may have regulatory capacities for Th1-mediated inflammation [11].
Negative_regulation (downmodulate) of Gene_expression (production) of IL-4 in macrophage associated with inflammation
11) Confidence 0.29 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.96 Pain Relevance 0.39
Therefore, Gourley et al. has suggested that the decrease in the granuloma size in the CIITA-/-I-E-transgenic mice might be due to the elevated IL-4 production, not a decrease in the IFN-?
Negative_regulation (decrease) of Gene_expression (production) of IL-4 associated with targeted disruption and granuloma
12) Confidence 0.28 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.78 Pain Relevance 0
Therefore, Gourley et al. has suggested that the decrease in the granuloma size in the CIITA-/-I-E-transgenic mice might be due to the elevated IL-4 production, not a decrease in the IFN-?
Negative_regulation (decrease) of Gene_expression (production) of IL-4 associated with targeted disruption and granuloma
13) Confidence 0.28 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.81 Pain Relevance 0
Under the same conditions, TGF-beta 1 induced a marked decrease in IL-4 and IL-5 mRNA expression in sRBC-sensitized splenocytes.
Negative_regulation (decrease) of Gene_expression (expression) of IL-4
14) Confidence 0.26 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9169066 Disease Relevance 0 Pain Relevance 0.12
CONCLUSIONS: The results demonstrate for the first time that a combination of viral infection and constitutive expression of IL-2, but not IFN-gamma or IL-4, can result in demyelination and visual impairment in the optic nerves of ocularly infected mice.


Negative_regulation (combination) of Gene_expression (expression) of IL-4 in optic nerves
15) Confidence 0.25 Published 2009 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 19234357 Disease Relevance 0.06 Pain Relevance 0
In a mouse model of experimental asthma, adoptive transfer of OVA specific TH1 cells reversed in a concentration-dependent manner TH2 cell derived IL-4 production, BAL eosinophilia and bronchial hyperresponsiveness [159, 160].
Negative_regulation (reversed) of Gene_expression (production) of IL-4 associated with asthma and eosinophilia
16) Confidence 0.25 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 1.11 Pain Relevance 0.28
Interleukin-4 production by local lymph nodes was suppressed with allyl isothiocyanate but not with capsaicin.
Neg (not) Negative_regulation (suppressed) of Gene_expression (production) of Interleukin-4 in lymph nodes
17) Confidence 0.24 Published 2007 Journal Int. Arch. Allergy Immunol. Section Body Doc Link 17259732 Disease Relevance 0 Pain Relevance 0
The production of the cytokine interleukin-2 by T helper cells was markedly suppressed in both tolerant and abstinent mice, whereas the production of interleukin-4 was significantly suppressed only in THC-abstinent mice.
Negative_regulation (suppressed) of Gene_expression (production) of interleukin-4 associated with cytokine
18) Confidence 0.23 Published 1996 Journal Pharmacology Section Abstract Doc Link 8807671 Disease Relevance 0.18 Pain Relevance 0.36
, but it significantly suppressed IL-4 production by spleen cells, resulting in an increased Th1/Th2 response.
Negative_regulation (suppressed) of Gene_expression (production) of IL-4 in spleen
19) Confidence 0.22 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 1.04 Pain Relevance 0.42
Similarly, IL-4 production also decreased after Bv8 administration at either time (Fig. 7, panel B).
Negative_regulation (decreased) of Gene_expression (production) of IL-4
20) Confidence 0.22 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.25 Pain Relevance 0.03

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