INT55897

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Context Info
Confidence 0.29
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.81
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C4a) extracellular region (C4a) molecular_function (C4a)
Anatomy Link Frequency
blood 1
spinal nerve 1
plasma 1
platelet 1
C4a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 13 99.52 Very High Very High Very High
Neuropathic pain 4 97.60 Very High Very High Very High
Spinal nerve ligature 5 97.06 Very High Very High Very High
spastic colon 1 95.64 Very High Very High Very High
anesthesia 3 95.24 Very High Very High Very High
Inflammatory marker 1 93.20 High High
Serotonin 1 90.72 High High
Inflammatory mediators 2 79.92 Quite High
Inflammatory response 1 78.00 Quite High
Pain 1 76.96 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 2 99.98 Very High Very High Very High
Acute Coronary Syndrome 12 99.84 Very High Very High Very High
Cv General 3 Under Development 13 99.52 Very High Very High Very High
Hemolysis 1 99.12 Very High Very High Very High
Neuropathic Pain 4 97.60 Very High Very High Very High
Adhesions 3 96.36 Very High Very High Very High
Functional Bowel Disorder 1 95.64 Very High Very High Very High
INFLAMMATION 9 93.20 High High
Disease 69 92.24 High High
Myocardial Infarction 6 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biopsies of colonic mucosa from patients with ulcerative colitis liberated more interleukin-1 beta, prostaglandin E2, leukotriene C4 and platelet-activating factor into the medium in which they were cultured than biopsies from patients with irritable bowel syndrome and histologically normal mucosa. 2.
Positive_regulation (liberated) of C4 in platelet associated with inflammatory bowel disease and spastic colon
1) Confidence 0.29 Published 1994 Journal Clin. Sci. Section Abstract Doc Link 8033515 Disease Relevance 0.35 Pain Relevance 0.14
In conclusion, increased serum C3/C4 ratio is a readily available and novel marker for recurrent cardiovascular events in acute coronary syndrome.
Positive_regulation (increased) of C4 associated with acute coronary syndrome
2) Confidence 0.15 Published 2007 Journal Am. J. Cardiol. Section Abstract Doc Link 17398178 Disease Relevance 0.39 Pain Relevance 0.06
In this study, we determined that plasma C3 and C4 levels were elevated in ACS and SA.
Positive_regulation (elevated) of C4 in plasma associated with acute coronary syndrome and angina
3) Confidence 0.15 Published 2005 Journal APMIS Section Abstract Doc Link 15799759 Disease Relevance 1.56 Pain Relevance 0.73
Gene-expression microarray-analysis performed on the rat spinal nerve ligation (SNL) model of neuropathic pain revealed that multiple complement components including the C1 inhibitor, C1q alpha, beta, and gamma, C1r, C1s, C2, C3, C4, C7, and factors B, D, H, and P, were up-regulated while DAF was down-regulated.
Positive_regulation (up-regulated) of C4 in spinal nerve associated with spinal nerve ligature and neuropathic pain
4) Confidence 0.14 Published 2008 Journal Pain Section Abstract Doc Link 18160218 Disease Relevance 0.56 Pain Relevance 1.01
In both groups of patients the serum concentrations of C3, C4, C5, and C1 inhibitor were significantly affected by the treatments (p < 0.001), decreased immediately after onset of anesthesia, were minimal during surgery, and increased thereafter.
Positive_regulation (concentrations) of C4 associated with anesthesia
5) Confidence 0.05 Published 1999 Journal Pediatr Cardiol Section Abstract Doc Link 9986887 Disease Relevance 0.17 Pain Relevance 0.13
No significant variation of ANA, anti-DNA and C4 levels was observed in the etanercept group.
Neg (No) Positive_regulation (variation) of C4
6) Confidence 0.04 Published 2008 Journal Clin. Exp. Rheumatol. Section Body Doc Link 18578960 Disease Relevance 0.15 Pain Relevance 0
The results of the multivariate analysis of construct validity were rather surprising, since we expected elevated anti-dsDNA level and/or C3 level, instead of elevated ESR and C4 level, to remain significantly associated with increasing overall scores on the BILAG-2004 index.
Positive_regulation (elevated) of C4
7) Confidence 0.02 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2659367 Disease Relevance 0.53 Pain Relevance 0
Mayer et al.[13] reported activation of the complement system and increased hemolysis in blood samples collected from healthy donors after being exposed to positively charged polystyrene nanoparticles.
Positive_regulation (activation) of complement in blood associated with hemolysis
8) Confidence 0.02 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2946263 Disease Relevance 0.10 Pain Relevance 0

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