INT55899

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Context Info
Confidence 0.63
First Reported 1994
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.70
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Ptafr) plasma membrane (Ptafr) nucleus (Ptafr)
signal transducer activity (Ptafr)
Anatomy Link Frequency
platelet 4
brain 2
Ptafr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spastic colon 2 96.88 Very High Very High Very High
bradykinin 1 96.66 Very High Very High Very High
cytokine 4 95.28 Very High Very High Very High
Hippocampus 6 91.44 High High
Inflammation 20 90.36 High High
Inflammatory mediators 6 82.40 Quite High
ischemia 20 81.92 Quite High
Pain 2 71.48 Quite High
cINOD 1 68.80 Quite High
IPN 2 53.24 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 3 99.98 Very High Very High Very High
Pleurisy 7 98.72 Very High Very High Very High
Functional Bowel Disorder 2 96.88 Very High Very High Very High
Retinopathy 1 93.16 High High
Disease 10 90.72 High High
INFLAMMATION 28 90.36 High High
Nociception 2 90.28 High High
Sickle Cell Anemia 1 89.80 High High
Diarrhoea 34 89.72 High High
Diabetes Mellitus 2 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Region-specific increases in brain levels of APP, neurofilament-70 (NF-70), and platelet-activating factor receptor (PAF-R) were found in EC rats.
Positive_regulation (increases) of PAF-R in brain
1) Confidence 0.63 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12492435 Disease Relevance 0.42 Pain Relevance 0.22
Region-specific increases in brain levels of APP, neurofilament-70 (NF-70), and platelet-activating factor receptor (PAF-R) were found in EC rats.
Positive_regulation (increases) of platelet-activating factor receptor in brain
2) Confidence 0.63 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12492435 Disease Relevance 0.42 Pain Relevance 0.22
However, mediators detected in the exudates of such pleurisies were different; in carrageenin-induced pleurisy bradykinin and prostacyclin (PGI2) caused exudate formation, while zymosan-induced pleurisy showed early degradation of mast cells and activation of complements, followed by an increase in platelet activating factor (PAF).
Positive_regulation (increase) of platelet activating factor in platelet associated with pleurisy and bradykinin
3) Confidence 0.30 Published 2000 Journal Yakugaku Zasshi Section Abstract Doc Link 10825809 Disease Relevance 1.33 Pain Relevance 0.58
Biopsies of colonic mucosa from patients with ulcerative colitis liberated more interleukin-1 beta, prostaglandin E2, leukotriene C4 and platelet-activating factor into the medium in which they were cultured than biopsies from patients with irritable bowel syndrome and histologically normal mucosa. 2.
Positive_regulation (liberated) of platelet-activating factor in platelet associated with inflammatory bowel disease and spastic colon
4) Confidence 0.21 Published 1994 Journal Clin. Sci. Section Abstract Doc Link 8033515 Disease Relevance 0.35 Pain Relevance 0.14
These actions, related to ricin oil's diarrheal effects, are involved in adenylate cyclase activation, secretion of mucosal cAMP, induction of platelet activating factor, increase in prostaglandin biosynthesis, and modification of nitric oxide concentration [12–34].
Positive_regulation (induction) of platelet activating factor in platelet
5) Confidence 0.16 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952297 Disease Relevance 0.78 Pain Relevance 0
These include; stimulation of the platelet activating factor, release of lysophosphatides, and disturbances of potassium, sodium, and calcium conductance.10
Positive_regulation (stimulation) of platelet activating factor in platelet
6) Confidence 0.07 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2819765 Disease Relevance 1.39 Pain Relevance 0.19

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