INT5590

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Context Info
Confidence 0.59
First Reported 1990
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 144
Total Number 147
Disease Relevance 40.94
Pain Relevance 81.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
spinal cord 14
neurons 12
nucleus 7
spinal 7
dorsal horn 5
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 305 100.00 Very High Very High Very High
Dorsal horn 188 100.00 Very High Very High Very High
Inflammation 180 100.00 Very High Very High Very High
Morphine 165 100.00 Very High Very High Very High
qutenza 155 100.00 Very High Very High Very High
allodynia 82 100.00 Very High Very High Very High
narcan 81 100.00 Very High Very High Very High
Hyperalgesia 38 100.00 Very High Very High Very High
Dorsal horn neuron 13 100.00 Very High Very High Very High
colic 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 276 100.00 Very High Very High Very High
Generalized Anxiety Disorder 194 100.00 Very High Very High Very High
Nociception 191 100.00 Very High Very High Very High
INFLAMMATION 159 100.00 Very High Very High Very High
Neuropathic Pain 150 100.00 Very High Very High Very High
Injury 77 100.00 Very High Very High Very High
Pancreatitis 56 100.00 Very High Very High Very High
Hyperalgesia 53 100.00 Very High Very High Very High
Aids-related Complex 39 100.00 Very High Very High Very High
Abdominal Cramps 4 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This reduction of Fos protein-LI cells following change in food hardness was reversed after i.v. application of naloxone.
Negative_regulation (reduction) of Fos associated with narcan
1) Confidence 0.59 Published 2003 Journal Neuroscience Section Abstract Doc Link 12927213 Disease Relevance 0.37 Pain Relevance 0.56
Protein synthesis inhibitor cycloheximide dose-dependently decreases formalin-induced c-Fos protein and behavioral hyperalgesia in rats.
Negative_regulation (decreases) of c-Fos protein associated with hyperalgesia
2) Confidence 0.59 Published 1997 Journal Neurosci. Lett. Section Title Doc Link 9180213 Disease Relevance 0.60 Pain Relevance 0.39
Fos inhibition patterns were inconsistent with behavioral studies of these anesthetics, suggesting that Fos inhibition does not always correlate with behavioral analgesia.
Negative_regulation (inhibition) of Fos associated with analgesia
3) Confidence 0.58 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 9972767 Disease Relevance 0.09 Pain Relevance 0.22
Replacement of the calcium in the bathing medium by 2 mM manganese suppressed all detectable c-fos-ir, whereas inclusion of 0.5 microM capsaicin caused intense c-fos-ir expression in the absence of stimulation.
Negative_regulation (suppressed) of c-fos-ir associated with qutenza
4) Confidence 0.58 Published 1998 Journal J. Neurosci. Methods Section Abstract Doc Link 9531466 Disease Relevance 0 Pain Relevance 0.33
The most remarkable inhibitory effect of c-fos ASO on allodynia is at the early stage after SNL, which supports the above concept: c-fos activation contributes more to the induction of allodynia.
Negative_regulation (effect) of c-fos ASO associated with allodynia and spinal nerve ligature
5) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.92 Pain Relevance 1.11
Drugs that suppressed bladder reflexes did not reduce c-fos induced by distension, indicating that voiding reflexes do not contribute to c-fos expression.
Neg (not) Negative_regulation (reduce) of c-fos in bladder associated with overactive bladder
6) Confidence 0.57 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8368386 Disease Relevance 0.67 Pain Relevance 0
In contrast, Fos-LI evoked by noxious pressure was strongly depressed by morphine.
Negative_regulation (depressed) of Fos associated with morphine
7) Confidence 0.57 Published 1993 Journal Pain Section Abstract Doc Link 8446434 Disease Relevance 0.59 Pain Relevance 1.14
Our results suggest that L-ARG plays an important role in inhibiting KA-induced proENK or proDYN mRNA expression, and its inhibitory action may be mediated through reducing the proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, c-Jun, JunD, and JunB.
Negative_regulation (reducing) of c-Fos
8) Confidence 0.57 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.06
Equi-analgesic doses of s.c. morphine (10 mg/kg) or tramadol (30 mg/kg) significantly suppressed c-fos-ir in all areas examined, except dorsal central gray of the spinal cord.
Negative_regulation (suppressed) of c-fos in spinal cord associated with tramadol, analgesic, spinal cord and morphine
9) Confidence 0.57 Published 1998 Journal Eur J Pain Section Abstract Doc Link 15102381 Disease Relevance 0 Pain Relevance 1.48
We also found that intra-CeA injection of DAMGO, prior to LiCl injection, decreased c-Fos IR levels in the CeA compared to vehicle-injected rats.
Negative_regulation (decreased) of c-Fos in CeA associated with amygdala
10) Confidence 0.57 Published 2004 Journal Brain Res. Section Abstract Doc Link 15223361 Disease Relevance 0 Pain Relevance 0.88
The antisense blockade of c-fos reduced the effect of caffeine on the expression of mRNAs for preprotachykinin A and neurotensin/neuromedin N in the ventrolateral caudate-putamen.
Negative_regulation (blockade) of c-fos in caudate-putamen
11) Confidence 0.57 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9421173 Disease Relevance 0 Pain Relevance 0
The efficacy of i.t. administered DAMGO suggests that a direct spinal action contributes to the inhibition of noxious stimulus-evoked Fos-LI in the spinal cord produced by systemically administered mu opioid receptor agonists such as morphine.
Negative_regulation (inhibition) of Fos in spinal associated with agonist, mu opioid receptor, morphine and spinal cord
12) Confidence 0.57 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9435201 Disease Relevance 0.07 Pain Relevance 1.21
MK-801 completely inhibited morphine-induced c-Fos in intact females but only caused partial inhibition in intact males; castrated males showed complete inhibition, which was reversed by testosterone, but gonadal steroids had no effect on this response in females.
Negative_regulation (inhibited) of c-Fos in gonadal associated with morphine
13) Confidence 0.57 Published 2002 Journal J. Appl. Physiol. Section Abstract Doc Link 11796656 Disease Relevance 0 Pain Relevance 0.70
Post-treatment with ketoprofen produced inhibition of c-Fos but parecoxib did not have any significant effect.
Negative_regulation (inhibition) of c-Fos
14) Confidence 0.57 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19463915 Disease Relevance 0.74 Pain Relevance 0.82
On the other hand, the suppression of c-fos induced by 100 Hz EA was only partially blocked by this opiate antagonist.
Negative_regulation (suppression) of c-fos associated with antagonist, opiate and electroacupuncture
15) Confidence 0.57 Published 1992 Journal Brain Res. Section Abstract Doc Link 1521149 Disease Relevance 0 Pain Relevance 1.61
MK-801 given i.v. reduced Fos-LI only in laminae I-II at the Vc/C2 transition.
Negative_regulation (reduced) of Fos
16) Confidence 0.57 Published 2000 Journal Pain Section Abstract Doc Link 10692604 Disease Relevance 0.32 Pain Relevance 0.92
The decrease of c-fos or Som level due to intrathecal injection of ACTH in rats with chronic pain was prevented by injection of cyproheptadine, but not by bicuculline and naloxone.
Negative_regulation (decrease) of c-fos associated with lasting pain, narcan and intrathecal
17) Confidence 0.57 Published 1999 Journal Sheng Li Xue Bao Section Abstract Doc Link 11972177 Disease Relevance 0.35 Pain Relevance 0.86
Morphine inhibition of Fos-LI produced in laminae I-II at the Vc/C2 junction region was diminished in vagotomized males compared to intact animals, but not affected in females.
Negative_regulation (inhibition) of Fos associated with morphine
18) Confidence 0.57 Published 2002 Journal Pain Section Abstract Doc Link 11932076 Disease Relevance 0.73 Pain Relevance 1.35
However, when sympathetic efferents were removed surgically 7-10 days prior to the experiment (n=6), only 32.07+/-9.03% of GABA-immunoreactive neuronal profiles were stained for Fos following CAP injection, a significant reduction in the CAP-evoked Fos-staining of GABAergic neurons after surgical sympathectomy.
Negative_regulation (reduction) of Fos-staining in neuronal associated with gaba, qutenza and gabaergic
19) Confidence 0.57 Published 2002 Journal Brain Res. Section Abstract Doc Link 12470868 Disease Relevance 0.14 Pain Relevance 1.02
Intra-gastric administration of tegaserod (2 mg/kg.d) resulted in a significant decrease of Fos labeled neurons (22.0+/-7.7) and SP density (12.5+/-1.4) in the dorsal horn in the lumbarsacral spinal cord compared to those of the control group (62.2+/-18.9, 35.9+/-8.9, P<0.05).
Negative_regulation (decrease) of Fos in spinal cord
20) Confidence 0.56 Published 2004 Journal World J. Gastroenterol. Section Body Doc Link 15188517 Disease Relevance 0.07 Pain Relevance 0

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