INT55908

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2010
Negated 9
Speculated 7
Reported most in Abstract
Documents 74
Total Number 81
Disease Relevance 34.46
Pain Relevance 28.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ngfr) signal transduction (Ngfr) nuclear envelope (Ngfr)
Golgi apparatus (Ngfr) plasma membrane (Ngfr) nucleus (Ngfr)
Anatomy Link Frequency
neurons 7
dorsal root ganglia 7
sciatic nerve 6
motoneurons 5
sensory neurons 5
Ngfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 2130 100.00 Very High Very High Very High
Nerve growth factor 561 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 3 100.00 Very High Very High Very High
Inflammation 102 99.92 Very High Very High Very High
Snapping jaw 11 99.88 Very High Very High Very High
Sciatic nerve 705 99.84 Very High Very High Very High
GABAergic 24 99.80 Very High Very High Very High
Peripheral nervous system 36 99.64 Very High Very High Very High
Sciatica 15 99.52 Very High Very High Very High
Inflammatory stimuli 1 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 103 99.92 Very High Very High Very High
Temporomandibular Joint Syndrome 11 99.88 Very High Very High Very High
Targeted Disruption 33 99.76 Very High Very High Very High
Sciatic Neuropathy 320 99.56 Very High Very High Very High
Apoptosis 144 99.44 Very High Very High Very High
Obesity 43 99.32 Very High Very High Very High
Polycystic Ovary Syndrome 609 99.26 Very High Very High Very High
Neurogenic Inflammation 1 99.24 Very High Very High Very High
Primary Sclerosing Cholangitis 12 99.20 Very High Very High Very High
Down Syndrome 8 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, direct p75NTR inhibitory antibody application decreased CGRP and p75NTR expression after wrist inflammation (p<.01).
Gene_expression (expression) of p75NTR in wrist
1) Confidence 0.78 Published 2010 Journal J Hand Surg Am Section Body Doc Link 20060234 Disease Relevance 0.06 Pain Relevance 0
We assessed CGRP and p75NTR expression in C8 dorsal root ganglia immunochemically.
Gene_expression (expression) of p75NTR in dorsal root ganglia
2) Confidence 0.78 Published 2010 Journal J Hand Surg Am Section Body Doc Link 20060234 Disease Relevance 0.08 Pain Relevance 0
Further immunological analysis showed that the p75 neurotrophin receptor (p75NTR) is expressed in 2% of both apoptotic and non apoptotic Schwann cells, while Ki-67, a marker of cell proliferation, is expressed in 20% of apoptotic and in 1% of non apoptotic Schwann cells.
Gene_expression (xpressed ) of p75 neurotrophin receptor in Schwann cells associated with apoptosis
3) Confidence 0.78 Published 1998 Journal J. Neurol. Sci. Section Abstract Doc Link 9879678 Disease Relevance 1.63 Pain Relevance 0.64
Further immunological analysis showed that the p75 neurotrophin receptor (p75NTR) is expressed in 2% of both apoptotic and non apoptotic Schwann cells, while Ki-67, a marker of cell proliferation, is expressed in 20% of apoptotic and in 1% of non apoptotic Schwann cells.
Gene_expression (xpressed ) of p75NTR in Schwann cells associated with apoptosis
4) Confidence 0.78 Published 1998 Journal J. Neurol. Sci. Section Abstract Doc Link 9879678 Disease Relevance 1.62 Pain Relevance 0.64
In this study we examined the developmental course of expression of the low-affinity neurotrophin receptor (LANR), a receptor that binds to all members of the neurotrophin family, in the IPN.
Gene_expression (expression) of low-affinity neurotrophin receptor in IPN associated with ipn
5) Confidence 0.76 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 8033962 Disease Relevance 0 Pain Relevance 0.37
P55 and P75 receptors were expressed by 29 and 62% of masseter nociceptors, respectively.
Gene_expression (expressed) of P75 in nociceptors associated with nociceptor
6) Confidence 0.75 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19553487 Disease Relevance 0.34 Pain Relevance 0.49
Low-affinity nerve growth factor receptor expression in sciatic nerve during P2-peptide induced experimental allergic neuritis.
Gene_expression (expression) of nerve growth factor receptor in sciatic nerve associated with nerve growth factor, experimental autoimmune neuritis, sciatic nerve and neuritis
7) Confidence 0.75 Published 1995 Journal Neurosci. Lett. Section Title Doc Link 8584242 Disease Relevance 0.62 Pain Relevance 0.71
By this time, however, p75NGFR was not detectable in roots of cauda equina.
Neg (not) Gene_expression (detectable) of p75NGFR
8) Confidence 0.75 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8584242 Disease Relevance 0.69 Pain Relevance 0.73
Northern blot, immunocytochemistry, and single nerve fiber immunostaining were used to determine the expression of low-affinity nerve growth factor (NGF) receptor (p75NGFR) in the peripheral nervous system of Lewis rats during the course of experimental allergic neuritis (EAN) induced with 100 micrograms of 'SP26' synthetic peptide, corresponding to residues 53-78 of bovine P2 myelin protein.
Spec (determine) Gene_expression (expression) of p75NGFR in nerve associated with peripheral nervous system, nerve growth factor, experimental autoimmune neuritis and neuritis
9) Confidence 0.75 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 8584242 Disease Relevance 0.48 Pain Relevance 0.54
All regenerating motoneurons expressed p75, but not nNOS, while all motoneurons that failed to regenerate expressed nNOS, but not p75. p75 and nNOS may, therefore, be used as markers for success or failure to regenerate axons.
Neg (not) Gene_expression (expressed) of p75 in motoneurons
10) Confidence 0.75 Published 2004 Journal J. Neurotrauma Section Abstract Doc Link 15319004 Disease Relevance 0.07 Pain Relevance 0
NGF and p75 expression (mRNA and protein) increases in the skin (keratinocytes) in the acute phase of CFA inflammation; 3). at this stage, a higher proliferative activity is observed in the skin, as defined by the expression of cell cycle-associated protein Ki67; 4). in the long-lasting chronic phase there is a further up-regulation of NFG and p75 expression in the skin; 5). trkA mRNA expression inversely correlates with p75 and NGF mRNA expression.
Gene_expression (expression) of p75 in keratinocytes associated with inflammation
11) Confidence 0.74 Published 2008 Journal Histol. Histopathol. Section Abstract Doc Link 17952852 Disease Relevance 0.65 Pain Relevance 0.40
In this paper we examined NGF and p75 receptor expression in the skin, during CFA induced inflammation, in a time-course study.
Spec (examined) Gene_expression (expression) of p75 in skin associated with inflammation
12) Confidence 0.74 Published 2008 Journal Histol. Histopathol. Section Abstract Doc Link 17952852 Disease Relevance 0.39 Pain Relevance 0.27
Destruction of p75-expressing fibers in the superficial dorsal horn by 192-IgG saporin was not accompanied by changes in acetylcholine or norepinephrine content or by reduction in cholinergic neuronal number in the spinal cord dorsal horn.
Gene_expression (expressing) of p75-expressing in neuronal associated with dorsal horn and spinal cord
13) Confidence 0.67 Published 2001 Journal Neuroscience Section Abstract Doc Link 11226704 Disease Relevance 0.59 Pain Relevance 0.97
Transient and permanent patterns of expression of the low-affinity neurotrophin receptor in the interpeduncular nucleus of the rat.
Gene_expression (expression) of low-affinity neurotrophin receptor in interpeduncular nucleus
14) Confidence 0.66 Published 1994 Journal Exp. Neurol. Section Title Doc Link 8033962 Disease Relevance 0 Pain Relevance 0.41
Here, we examined the effect of inflammation on expression of the low affinity neurotrophin receptor p75, using the model of cyclophosphamide-induced cystitis in rats.
Gene_expression (expression) of neurotrophin receptor associated with inflammation and cystitis
15) Confidence 0.66 Published 1996 Journal Neuroreport Section Abstract Doc Link 8817519 Disease Relevance 0.37 Pain Relevance 0.32
All regenerating motoneurons expressed p75, but not nNOS, while all motoneurons that failed to regenerate expressed nNOS, but not p75. p75 and nNOS may, therefore, be used as markers for success or failure to regenerate axons.
Neg (not) Gene_expression (expressed) of p75 in motoneurons
16) Confidence 0.65 Published 2004 Journal J. Neurotrauma Section Abstract Doc Link 15319004 Disease Relevance 0.07 Pain Relevance 0
All regenerating motoneurons expressed p75, but not nNOS, while all motoneurons that failed to regenerate expressed nNOS, but not p75. p75 and nNOS may, therefore, be used as markers for success or failure to regenerate axons.
Neg (not) Gene_expression (expressed) of p75 in motoneurons
17) Confidence 0.65 Published 2004 Journal J. Neurotrauma Section Abstract Doc Link 15319004 Disease Relevance 0.07 Pain Relevance 0
Alterations of nerve-growth factor and p75(NTR) expressions in urinary bladder of fructose-fed obese rats.
Gene_expression (expressions) of p75 in urinary bladder associated with obesity
18) Confidence 0.63 Published 2008 Journal Neurosci. Lett. Section Title Doc Link 18585860 Disease Relevance 0.36 Pain Relevance 0.08
In conclusion, long-term metabolic syndrome in FR significantly decreases bladder NGF and p75(NTR) expression.
Gene_expression (expression) of p75 in bladder associated with metabolic syndrome
19) Confidence 0.63 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18585860 Disease Relevance 0.24 Pain Relevance 0.06
The study investigated the effects of metabolic syndrome on urinary bladder nerve-growth factor (NGF) and p75(NTR) expression in fructose-fed obese rats.
Spec (investigated) Gene_expression (expression) of p75 in nerve associated with obesity and metabolic syndrome
20) Confidence 0.63 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18585860 Disease Relevance 0.32 Pain Relevance 0.08

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