INT5591

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Context Info
Confidence 0.62
First Reported 1990
Last Reported 2010
Negated 71
Speculated 75
Reported most in Abstract
Documents 425
Total Number 501
Disease Relevance 129.06
Pain Relevance 265.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
spinal cord 120
spinal 119
brain 71
neurons 48
nucleus 40
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 844 100.00 Very High Very High Very High
Pain 619 100.00 Very High Very High Very High
Morphine 562 100.00 Very High Very High Very High
antagonist 508 100.00 Very High Very High Very High
Nerve growth factor 480 100.00 Very High Very High Very High
Dorsal horn 469 100.00 Very High Very High Very High
qutenza 360 100.00 Very High Very High Very High
amygdala 350 100.00 Very High Very High Very High
Inflammation 341 100.00 Very High Very High Very High
Glutamate 312 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 568 100.00 Very High Very High Very High
Pain 443 100.00 Very High Very High Very High
Neuropathic Pain 395 100.00 Very High Very High Very High
Anxiety Disorder 379 100.00 Very High Very High Very High
INFLAMMATION 295 100.00 Very High Very High Very High
Stress 223 100.00 Very High Very High Very High
Injury 173 100.00 Very High Very High Very High
Pressure And Volume Under Development 168 100.00 Very High Very High Very High
Hyperalgesia 143 100.00 Very High Very High Very High
Generalized Anxiety Disorder 80 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test the possibility that this activation comes directly from the amygdala, we looked at changes in Fos expression after a unilateral blockade of the ventral amygdalofugal pathway with lidocaine.
Regulation (changes) of Gene_expression (expression) of Fos in ventral associated with lidocaine and amygdala
1) Confidence 0.62 Published 2000 Journal Neuroscience Section Abstract Doc Link 10682714 Disease Relevance 0.58 Pain Relevance 0.60
Pretreatment with morphine 30 min before pulp exposure dose-dependently (2.5, 5, and 10 mg/kg subcutaneously) reduced Fos expression in subnucleus caudalis whereas pretreatment with ibuprofen (10-100 mg/kg subcutaneously) did not significantly affect Fos expression.
Neg (not) Regulation (affect) of Gene_expression (expression) of Fos associated with morphine
2) Confidence 0.62 Published 2005 Journal J Endod Section Abstract Doc Link 16044040 Disease Relevance 0.29 Pain Relevance 1.09
Local anesthetic pretreatment was effective in reducing Fos expression only for the long acting bupivacaine; lidocaine without and with epinephrine (1:100,000) failed to significantly affect Fos expression.
Neg (failed) Regulation (affect) of Gene_expression (expression) of Fos associated with lidocaine and local anesthetic
3) Confidence 0.62 Published 2005 Journal J Endod Section Abstract Doc Link 16044040 Disease Relevance 0.30 Pain Relevance 1.16
Effects of pre-emptive morphine, ibuprofen or local anesthetic on fos expression in the spinal trigeminal nucleus following tooth pulp exposure in the rat.
Regulation (Effects) of Gene_expression (expression) of fos in spinal trigeminal nucleus associated with local anesthetic and morphine
4) Confidence 0.62 Published 2005 Journal J Endod Section Title Doc Link 16044040 Disease Relevance 0.18 Pain Relevance 0.70
Exposure of the tooth pulp produced a significant increase in Fos-like immunoreactivity in the superficial laminae of subnucleus caudalis; pretreatment with a control infiltration injection of saline directly above the maxillary molar 30 min before pulp exposure had no effect on Fos expression.
Neg (no) Regulation (effect) of Gene_expression (expression) of Fos in molar
5) Confidence 0.62 Published 2005 Journal J Endod Section Abstract Doc Link 16044040 Disease Relevance 0.22 Pain Relevance 0.74
Given the effects of local anesthetic on Fos expression, a combination of long acting local anesthetic with pre-emptive opioid would likely be most efficacious in decreasing postoperative dental pain.
Regulation (effects) of Gene_expression (expression) of Fos associated with pain, opioid and local anesthetic
6) Confidence 0.62 Published 2005 Journal J Endod Section Abstract Doc Link 16044040 Disease Relevance 0.40 Pain Relevance 1.20
Lesioning the VLMlat with quinolinic acid prevented the decrease in Fos expression at the spinal cord of DPSPX-hypertensive rats whereas in normotensive animals, no changes in Fos expression were detected.
Neg (no) Regulation (changes) of Gene_expression (expression) of Fos in spinal cord associated with hypertension and spinal cord
7) Confidence 0.62 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16453312 Disease Relevance 1.06 Pain Relevance 0.78
A higher dose of fluoxetine (10 mg/kg) did not change escape responses and had no effect on stress-induced Fos expression in the LC, but decreased airjet-induced Fos expression in the medial amygdala.
Neg (no) Regulation (effect) of Gene_expression (expression) of Fos in amygdala associated with stress, locus ceruleus, amygdala and fluoxetine
8) Confidence 0.62 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12527473 Disease Relevance 0.39 Pain Relevance 1.04
This study compares the effects of two non-steroidal anti-inflammatory drugs, Bufferin A (BA) and L-5409709 (L-54), on nociceptive behaviour and spinal Fos expression induced by subcutaneous formalin in the rat.
Regulation (effects) of Gene_expression (expression) of Fos in spinal associated with nociception, inflammation and cinod
9) Confidence 0.62 Published 1997 Journal Pain Section Abstract Doc Link 9150301 Disease Relevance 0.35 Pain Relevance 0.42
In the second study, the effects of the administration of adrenoceptor antagonists on withdrawal-induced Fos expression in the heart were studied.
Regulation (effects) of Gene_expression (expression) of Fos in heart associated with antagonist and withdrawal
10) Confidence 0.62 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15249992 Disease Relevance 0.08 Pain Relevance 1.33
Effect of electrical stimulation of the cerebral cortex on the expression of the Fos protein in the basal ganglia.
Regulation (Effect) of Gene_expression (expression) of Fos in basal ganglia associated with enkephalin and cerebral cortex
11) Confidence 0.62 Published 1997 Journal Neuroscience Section Title Doc Link 9300404 Disease Relevance 0.14 Pain Relevance 0.19
The present study investigated the effect of cortical electrical stimulation on the expression of Fos in the basal ganglia in the rat, a group of structures that participate in sensorimotor learning.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of Fos in basal ganglia
12) Confidence 0.62 Published 1997 Journal Neuroscience Section Abstract Doc Link 9300404 Disease Relevance 0.15 Pain Relevance 0.08
However, Fos expression after E-acupuncture to the pads of the hindpaw was unaffected by the same treatment.
Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of Fos associated with acupuncture
13) Confidence 0.62 Published 2003 Journal Brain Res. Section Abstract Doc Link 12834907 Disease Relevance 0 Pain Relevance 0.91
We then examined dopaminergic and glutamatergic mechanisms for anesthetic effects on cocaine-induced Fos expression.
Spec (examined) Regulation (effects) of Gene_expression (expression) of Fos associated with cocaine
14) Confidence 0.62 Published 2004 Journal Neuroscience Section Abstract Doc Link 15219685 Disease Relevance 0 Pain Relevance 0.61
In addition, infusion of calphostin C (another protein kinase C inhibitor, which interacts with its regulatory domain) did not modify the morphine withdrawal-induced expression of Fos.
Neg (not) Regulation (modify) of Gene_expression (expression) of Fos associated with withdrawal, morphine and kinase c inhibitor
15) Confidence 0.62 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11698063 Disease Relevance 0.08 Pain Relevance 1.17
The effect of electroacupuncture on pain behaviors and noxious stimulus-evoked Fos expression in a rat model of neuropathic pain.
Regulation (effect) of Gene_expression (expression) of Fos associated with pain, neuropathic pain and electroacupuncture
16) Confidence 0.62 Published 2001 Journal J Pain Section Title Doc Link 14622825 Disease Relevance 1.06 Pain Relevance 1.19
In this study, we examined the antinociceptive effect of electroacupuncture (EA) on pain behavior and noxious stimulus-evoked Fos expression in dorsal horn neurons of the spinal cord in CCI rats 14 days after injury.
Spec (examined) Regulation (effect) of Gene_expression (expression) of Fos in neurons associated with pain, injury, dorsal horn neuron, electroacupuncture, antinociceptive and spinal cord
17) Confidence 0.62 Published 2001 Journal J Pain Section Abstract Doc Link 14622825 Disease Relevance 1.13 Pain Relevance 1.34
In this study, we examined the effect of intrathecal L-NAME, a non-selective nitric oxide synthase (NOS) inhibitor, on nociceptive behavior and spinal Fos expression in rats following chronic constriction injury (CCI) of sciatic nerve, a model of neuropathic pain similar to that observed in clinical setting.
Spec (examined) Regulation (effect) of Gene_expression (expression) of Fos in sciatic nerve associated with nociception, eae, injury, neuropathic pain, sciatic nerve and intrathecal
18) Confidence 0.62 Published 2007 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 17694681 Disease Relevance 0.30 Pain Relevance 0.45
Effect of intrathecal NG-nitro-L-arginine methyl ester administration on Fos expression in the spinal dorsal horn in rats following sciatic nerve ligation.
Regulation (Effect) of Gene_expression (expression) of Fos in spinal associated with spinal dorsal horn, sciatic nerve and intrathecal
19) Confidence 0.62 Published 2007 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Title Doc Link 17694681 Disease Relevance 0.08 Pain Relevance 0.44
The influences of different treatments on the expression of the c-fos gene in the spinal cord and brain (hypothalamus) was studied in rats using various types of anesthesia.
Regulation (influences) of Gene_expression (expression) of c-fos gene in brain associated with anesthesia and spinal cord
20) Confidence 0.61 Published 2004 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 15341219 Disease Relevance 0.19 Pain Relevance 0.74

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