INT55919

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Context Info
Confidence 0.02
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.84
Pain Relevance 0.60

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transport (Sigmar1, Ap2s1) plasma membrane (Sigmar1, Ap2s1) protein transporter activity (Ap2s1)
nuclear envelope (Sigmar1) vesicle-mediated transport (Ap2s1) lipid particle (Sigmar1)
Sigmar1 (Mus musculus)
Ap2s1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 1 99.82 Very High Very High Very High
Opioid 8 98.94 Very High Very High Very High
fortral 2 97.04 Very High Very High Very High
opioid receptor 2 37.76 Quite Low
Disease Link Frequency Relevance Heat
Cancer 3 98.32 Very High Very High Very High
Glioma 4 92.16 High High
Neuroblastoma 5 91.44 High High
Solid Tumor 3 82.24 Quite High
Brain Tumor 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At each generation, tumors were analyzed for delta opioid binding using [3H][D-Ala2,D-Leu5]enkephalin and for sigma 1 and sigma 2 binding with 1,3-[3H]di-o-tolylguanidine in the presence and absence of 1 microM pentazocine.
sigma 1 Binding (binding) of sigma 2 associated with fortral, cancer, enkephalin and opioid
1) Confidence 0.02 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8035181 Disease Relevance 0.84 Pain Relevance 0.60

General Comments

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