INT5592

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Context Info
Confidence 0.62
First Reported 1982
Last Reported 2003
Negated 5
Speculated 4
Reported most in Abstract
Documents 36
Total Number 40
Disease Relevance 4.37
Pain Relevance 24.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
hippocampus 18
brain 12
striatum 11
pituitary 5
chromaffin cells 4
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 219 100.00 Very High Very High Very High
Hippocampus 32 100.00 Very High Very High Very High
Neuropeptide 25 100.00 Very High Very High Very High
isoflurane 18 100.00 Very High Very High Very High
aspirin 18 100.00 Very High Very High Very High
anesthesia 12 100.00 Very High Very High Very High
Dopamine 11 100.00 Very High Very High Very High
substance P 10 100.00 Very High Very High Very High
Dynorphin 7 100.00 Very High Very High Very High
Pain 3 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 21 100.00 Very High Very High Very High
Shock 8 98.84 Very High Very High Very High
Toxicity 2 98.32 Very High Very High Very High
Ganglion Cysts 3 95.20 Very High Very High Very High
Injury 1 94.64 High High
Pain 2 91.24 High High
Body Weight 3 87.96 High High
Urological Neuroanatomy 5 87.04 High High
Hypoxia 1 83.56 Quite High
Eating Disorder 4 79.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The goal of this study was to delineate the effects of dopamine antagonists on the regulation of preproenkephalin mRNA and opioid peptides in the rat brain.
Regulation (effects) of Regulation (regulation) of preproenkephalin in brain associated with dopamine, antagonist and opioid
1) Confidence 0.62 Published 1990 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2170802 Disease Relevance 0 Pain Relevance 0.33
These data indicate that c-fos and proenkephalin mRNA are not regulated in a sequential, parallel manner, that newly synthesized c-fos is not the determining factor controlling proenkephalin gene regulation, and that c-fos expression is under negative control by glucocorticoids.
Neg (not) Spec (determining) Regulation (controlling) of Spec (determining) Regulation (regulation) of proenkephalin
2) Confidence 0.60 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1312200 Disease Relevance 0.15 Pain Relevance 0.08
Effect of melatonin on the regulation of proenkephalin and prodynorphin mRNA levels induced by kainic acid in the rat hippocampus.
Regulation (Effect) of Regulation (regulation) of proenkephalin in hippocampus associated with enkephalin and hippocampus
3) Confidence 0.58 Published 2000 Journal Hippocampus Section Title Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.19
These results indicate a role for preganglionic fibres in the developmental regulation of ENK in the chromaffin cells.
Regulation (role) of Regulation (regulation) of ENK in chromaffin cells
4) Confidence 0.58 Published 1996 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8946057 Disease Relevance 0.19 Pain Relevance 0.15
Roles of the pituitary-adrenocortical axis in control of the native and cryptic enkephalin levels and proenkephalin mRNA in the sympathoadrenal system of the rat.
Regulation (Roles) of Regulation (control) of proenkephalin in pituitary associated with enkephalin
5) Confidence 0.56 Published 1988 Journal Brain Res. Section Title Doc Link 3401703 Disease Relevance 0 Pain Relevance 1.68
The effect of L-arginine (L-ARG), a nitric oxide donor, or Nomega-nitro-L-arginine (L-NAME), a nitric oxide synthase inhibitor, on the regulation of kainic acid (KA)-induced proenkephalin (proENK) and prodynorphin (proDYN) mRNA expressions in rat hippocampus was studied.
Regulation (effect) of Regulation (regulation) of proenkephalin in hippocampus associated with hippocampus
6) Confidence 0.48 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.09
Dopamine exerts a tonic inhibitory control in the regulation of mRNA encoding preproenkephalin (PPE), the precursor of enkephalin, in the dorsal part of the rat striatum.
Regulation (control) of Regulation (regulation) of preproenkephalin in striatum associated with dopamine and enkephalin
7) Confidence 0.45 Published 1993 Journal Neuroreport Section Abstract Doc Link 8513136 Disease Relevance 0 Pain Relevance 0.37
The role of neuropeptides in the regulation of adrenal zona fasciculata/reticularis function.
Regulation (regulation) of Regulation (Effects) of Leu-enkephalin in adrenal gland associated with neuropeptide
8) Confidence 0.45 Published 1994 Journal Neuropeptides Section Title Doc Link 7523979 Disease Relevance 0 Pain Relevance 0.64
To determine the possible role of cyclooxygenase/lipoxygenase pathway in the regulation of proenkephalin (proENK) and prodynorphin (proDYN) gene expression induced by kainic acid (KA) in rat hippocampus, the effects of esculetin, aspirin, or phenidone on the seizure activity, proENK and proDYN mRNA levels, and the level of fos-related antigene (Fra) protein induced by KA in rat hippocampus were studied.
Spec (possible) Regulation (role) of Spec (possible) Regulation (regulation) of proenkephalin in hippocampus associated with aspirin, convulsion and hippocampus
9) Confidence 0.44 Published 1998 Journal Brain Res. Section Abstract Doc Link 9519284 Disease Relevance 0.21 Pain Relevance 0.24
To determine the possible role of cyclooxygenase/lipoxygenase pathway in the regulation of proenkephalin (proENK) and prodynorphin (proDYN) gene expression induced by kainic acid (KA) in rat hippocampus, the effects of esculetin, aspirin, or phenidone on the seizure activity, proENK and proDYN mRNA levels, and the level of fos-related antigene (Fra) protein induced by KA in rat hippocampus were studied.
Regulation (role) of Regulation (effects) of proENK in hippocampus associated with aspirin, convulsion and hippocampus
10) Confidence 0.44 Published 1998 Journal Brain Res. Section Abstract Doc Link 9519284 Disease Relevance 0.24 Pain Relevance 0.26
These studies suggest that alterations in enkephalin and dynorphin in the limbic system may contribute to the behavioral changes observed after repeated ECSs.
Spec (may) Regulation (contribute) of Regulation (alterations) of enkephalin associated with dynorphin, shock, enkephalin and limbic system
11) Confidence 0.44 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2860612 Disease Relevance 0.74 Pain Relevance 0.61
[Effect of prostaglandins, cyclic nucleotides and ions on the analgesic effect of enkephalin analogs].
Regulation ([Effect) of Regulation (effect) of enkephalin associated with analgesic and enkephalin
12) Confidence 0.44 Published 1982 Journal Biull Eksp Biol Med Section Title Doc Link 7150767 Disease Relevance 0.17 Pain Relevance 1.21
Evidence for Fos involvement in the regulation of proenkephalin and prodynorphin gene expression in the rat hippocampus.
Regulation (involvement) of Regulation (regulation) of proenkephalin in hippocampus associated with enkephalin and hippocampus
13) Confidence 0.44 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9555037 Disease Relevance 0.35 Pain Relevance 0.18
The role of neuropeptides in the regulation of adrenal vascular tone: effects of vasoactive intestinal polypeptide, substance P, neuropeptide Y, neurotensin, Met-enkephalin, and Leu-enkephalin on perfusion medium flow rate in the intact perfused rat adrenal.
Regulation (role) of Regulation (effects) of enkephalin associated with neuropeptide, enkephalin and substance p
14) Confidence 0.44 Published 1994 Journal Regul. Pept. Section Title Doc Link 7518603 Disease Relevance 0 Pain Relevance 0.73
Here we focused on the role of the 5' proximal regulatory cassette (-190; +53 bp) of the rat enkephalin (rENK) gene in the developmental regulation of the enkephalin phenotype.
Regulation (role) of Regulation (regulation) of enkephalin in proximal associated with enkephalin
15) Confidence 0.44 Published 1995 Journal Mol. Neurobiol. Section Abstract Doc Link 7576307 Disease Relevance 0 Pain Relevance 0.31
The effect of cycloheximide on the regulation of proenkephalin and prodynorphin gene expressions induced by kainic acid in rat hippocampus.
Regulation (effect) of Regulation (regulation) of proenkephalin in hippocampus associated with enkephalin and hippocampus
16) Confidence 0.42 Published 1997 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.29
To determine the possible role of cyclooxygenase/lipoxygenase pathway in the regulation of proenkephalin (proENK) and prodynorphin (proDYN) gene expression induced by kainic acid (KA) in rat hippocampus, the effects of esculetin, aspirin, or phenidone on the seizure activity, proENK and proDYN mRNA levels, and the level of fos-related antigene (Fra) protein induced by KA in rat hippocampus were studied.
Spec (possible) Regulation (role) of Spec (possible) Regulation (regulation) of proENK in hippocampus associated with aspirin, convulsion and hippocampus
17) Confidence 0.38 Published 1998 Journal Brain Res. Section Abstract Doc Link 9519284 Disease Relevance 0.21 Pain Relevance 0.24
Since striatal D2 receptor-mediated inhibition of adenylate cyclase activity, in contrast to its activation through D1 receptors, is not present in the prenatal period, this study indicates that the tonic inhibitory effect of DA on striatal ppEnk mRNA synthesis is dependent on the presence of adenylate cyclase-coupled D2 receptors which gradually develops postnatally and further supports the idea that striatal D1 and D2 DA receptors have bidirectional effects on enkephalin synthesis in this brain area.
Regulation (dependent) of Regulation (effect) of ppEnk mRNA in brain associated with dopamine and enkephalin
18) Confidence 0.38 Published 1994 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 7913003 Disease Relevance 0 Pain Relevance 0.74
The obtained results support the view that Fos may be involved in regulation of the PENK and PDYN gene expression in the dentate gyrus during seizures, which further suggests that the mechanisms triggering the up-regulation of both these genes in the dentate gyrus may differ from these working in other brain regions, such as the striatum and hypothalamus.
Regulation (involved) of Regulation (regulation) of PENK in striatum associated with convulsion
19) Confidence 0.37 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555037 Disease Relevance 0.42 Pain Relevance 0.09
Cysteamine pretreatment of rats (depletion of somatostatin containing D-cells and decrease in somatostatin secretion) did not change the Met-enkephalin effect on insulin secretion.
Neg (not) Regulation (change) of Regulation (effect) of Met-enkephalin associated with somatostatin and enkephalin
20) Confidence 0.36 Published 1986 Journal Biochim. Biophys. Acta Section Abstract Doc Link 2874836 Disease Relevance 0 Pain Relevance 1.70

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