INT5593

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Context Info
Confidence 0.70
First Reported 1987
Last Reported 2010
Negated 2
Speculated 10
Reported most in Abstract
Documents 114
Total Number 125
Disease Relevance 29.10
Pain Relevance 74.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn) plasma membrane (Pdyn)
Anatomy Link Frequency
nucleus accumbens 22
spinal cord 20
brain 16
hippocampus 16
neurons 14
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 306 100.00 Very High Very High Very High
cocaine 179 100.00 Very High Very High Very High
Enkephalin 171 100.00 Very High Very High Very High
Inflammation 138 100.00 Very High Very High Very High
Spinal cord 134 100.00 Very High Very High Very High
Pain 56 100.00 Very High Very High Very High
Dorsal horn 38 100.00 Very High Very High Very High
substance P 34 100.00 Very High Very High Very High
gABA 16 100.00 Very High Very High Very High
orphanin 10 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 16 100.00 Very High Very High Very High
Aids-related Complex 5 100.00 Very High Very High Very High
Sprains And Strains 10 99.98 Very High Very High Very High
INFLAMMATION 129 99.96 Very High Very High Very High
Arthritis 13 99.82 Very High Very High Very High
Vibrio Infection 15 99.70 Very High Very High Very High
Pain 73 99.62 Very High Very High Very High
Dyskinesias 33 99.60 Very High Very High Very High
Urological Neuroanatomy 13 99.52 Very High Very High Very High
Alzheimer's Dementia 7 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This treatment produced significant increases in PDYN gene expression in the hypothalamus (183% of control), nucleus accumbens (142% of control) and hippocampus (124% of control) and a significant decrease in the caudate putamen (69% of control).
Positive_regulation (increases) of Gene_expression (expression) of PDYN gene in hippocampus associated with nucleus accumbens and hippocampus
1) Confidence 0.70 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15306127 Disease Relevance 0 Pain Relevance 0.70
Thus, the inhibition of NE uptake alone cannot account for the cocaine-induced increase of PDYN gene expression.
Positive_regulation (increase) of Gene_expression (expression) of PDYN gene associated with cocaine
2) Confidence 0.70 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15306127 Disease Relevance 0 Pain Relevance 0.61
In the nucleus accumbens, morphine and oxycodone-6-oxime did not change, while 14-methoxymetopon increased the prodynorphin gene expression.
Positive_regulation (increased) of Gene_expression (expression) of prodynorphin in nucleus accumbens associated with oxycodone, nucleus accumbens and morphine
3) Confidence 0.70 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16861108 Disease Relevance 0.08 Pain Relevance 1.66
Because we previously reported that continuous infusion of cocaine for 7 d (which inhibits dopamine, serotonin, and norepinephrine uptake), or GBR 12909 (a selective dopamine uptake inhibitor), produced significant decreases in the hypothalamus and cocaine also produced a significant increase in prodynorphin gene expression in caudate putamen, regulation of prodynorphin gene expression by fluoxetine is suggested to be different from that by cocaine.
Positive_regulation (increase) of Gene_expression (expression) of prodynorphin in caudate putamen associated with dopamine, serotonin, fluoxetine and cocaine
4) Confidence 0.70 Published 2004 Journal J. Mol. Neurosci. Section Abstract Doc Link 14997015 Disease Relevance 0 Pain Relevance 1.06
Northern blot analysis showed significant increases in prodynorphin gene expression in the hypothalamus (171% of controls) and significant decreases in the caudate putamen and nucleus accumbens (62% and 70% of controls, respectively).
Positive_regulation (increases) of Gene_expression (expression) of prodynorphin in nucleus accumbens associated with nucleus accumbens
5) Confidence 0.70 Published 2004 Journal J. Mol. Neurosci. Section Abstract Doc Link 14997015 Disease Relevance 0 Pain Relevance 0.66
These results, taken together with our previous observations, suggest that chronic opioid antagonists, acting on kappa and mu opioid receptors, clearly up-regulate prodynorphin gene expression in discrete rat brain regions, activating its biosynthesis.
Positive_regulation (up-regulate) of Gene_expression (expression) of prodynorphin gene in brain associated with antagonist, mu opioid receptor and opioid
6) Confidence 0.70 Published 1995 Journal Brain Res. Section Abstract Doc Link 7749752 Disease Relevance 0 Pain Relevance 1.05
Identification of multiple DNA elements regulating basal and protein kinase A-induced transcriptional expression of the rat prodynorphin gene.
Positive_regulation (induced) of Gene_expression (expression) of prodynorphin gene associated with enkephalin
7) Confidence 0.70 Published 1994 Journal Mol. Endocrinol. Section Title Doc Link 8015551 Disease Relevance 0 Pain Relevance 0.24
Quantitative analysis suggested that the evoked fos immunoreactivity was accompanied by an increased preprodynorphin mRNA expression.
Positive_regulation (increased) of Gene_expression (expression) of preprodynorphin mRNA
8) Confidence 0.70 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9753144 Disease Relevance 0.07 Pain Relevance 0.23
This implies that activity in the raphe-striatal serotonin pathway mediates a tonic and selective enhancement of prodynorphin gene expression in the striatal target cells.
Positive_regulation (mediates) of Gene_expression (expression) of prodynorphin gene associated with serotonin and raphe
9) Confidence 0.70 Published 1988 Journal Brain Res. Section Abstract Doc Link 3179742 Disease Relevance 0 Pain Relevance 0.43
We found a specific activation of PDYN mRNA expression in the limbic-innervated patch/striosome compartment of the dorsal caudate and dorsal putamen during the initial (i.e. 5 day) phase of the high dose cocaine self-administration.
Positive_regulation (activation) of Gene_expression (expression) of PDYN mRNA in dorsal associated with cocaine
10) Confidence 0.69 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12786988 Disease Relevance 0 Pain Relevance 0.31
Acute administration of amphetamine (2.5 mg/kg i.p.) caused an increase in behavioral activity and preprodynorphin, substance P, and preproenkephalin mRNA expression.
Positive_regulation (caused) of Gene_expression (expression) of preprodynorphin associated with substance p
11) Confidence 0.67 Published 2003 Journal Neuroscience Section Abstract Doc Link 14521997 Disease Relevance 0.09 Pain Relevance 0.53
Acute administration of amphetamine (2.5 mg/kg i.p.) caused an increase in behavioral activity and preprodynorphin, substance P, and preproenkephalin mRNA expression.
Positive_regulation (increase) of Gene_expression (expression) of preprodynorphin associated with substance p
12) Confidence 0.67 Published 2003 Journal Neuroscience Section Abstract Doc Link 14521997 Disease Relevance 0.09 Pain Relevance 0.53
To evaluate the specificity of neuropeptide processing enzymes, rat prodynorphin was transfected into BRL-3A cells, a rat liver-derived cell line which produces insulin-like growth factor II, but does not normally express prodynorphin.
Positive_regulation (transfected) of Gene_expression (transfected) of prodynorphin in liver associated with neuropeptide
13) Confidence 0.67 Published 1993 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 8375574 Disease Relevance 0 Pain Relevance 0.23
Prodynorphin gene expression in spinal cord is enhanced after traumatic injury in the rat.
Positive_regulation (enhanced) of Gene_expression (expression) of Prodynorphin in spinal cord associated with injury, enkephalin and spinal cord
14) Confidence 0.66 Published 1988 Journal Brain Res. Section Title Doc Link 2460195 Disease Relevance 0.19 Pain Relevance 0.80
A nitric oxide synthase inhibitor L-nitro-arginine methyl ester (L-NAME, 10, 50 mg/kg i.p.) had no effect on the level of prodynorphin mRNA, but prevented dose-dependently the amphetamine-induced increase in prodynorphin gene expression in both the nucleus accumbens and the striatum. 5.
Positive_regulation (increase) of Gene_expression (expression) of prodynorphin gene in nucleus accumbens associated with nucleus accumbens
15) Confidence 0.65 Published 1996 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 8938822 Disease Relevance 0 Pain Relevance 0.14
Nitric oxide synthase inhibitor L-NAME prevents amphetamine-induced prodynorphin gene expression in the rat.
Positive_regulation (induced) of Gene_expression (expression) of prodynorphin gene associated with enkephalin
16) Confidence 0.65 Published 1996 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Title Doc Link 8938822 Disease Relevance 0 Pain Relevance 0.32
Systemic treatment with the glucocorticosteroid budesonide attenuated the arthritis-induced increase of prodynorphin mRNA expression in a topospecific manner.
Positive_regulation (increase) of Gene_expression (expression) of prodynorphin mRNA associated with arthritis
17) Confidence 0.65 Published 1994 Journal Neuroscience Section Abstract Doc Link 7898656 Disease Relevance 0.74 Pain Relevance 0.60
Since the intermittent morphine administration induced long-term behavioral sensitization much more effectively than the chronic morphine treatment, we tentatively suggest that the protracted increase of preprodynorphin gene expression may play a facilitative role in the long-term character of opiate-induced behavioral sensitization.
Positive_regulation (increase) of Gene_expression (expression) of preprodynorphin gene associated with opiate and morphine
18) Confidence 0.65 Published 1997 Journal Neuroscience Section Abstract Doc Link 8971769 Disease Relevance 0 Pain Relevance 1.12
In contrast, a protracted increase of preprodynorphin gene expression of about 20% throughout the caudate-putamen and of about 6% in intermediate sections of the nucleus accumbens was observed 21 days after cessation of intermittent morphine treatment.
Positive_regulation (increase) of Gene_expression (expression) of preprodynorphin gene in nucleus accumbens associated with nucleus accumbens and morphine
19) Confidence 0.65 Published 1997 Journal Neuroscience Section Abstract Doc Link 8971769 Disease Relevance 0 Pain Relevance 1.36
A significant upregulation of prodynorphin gene expression occurred only in injured DRG of F344 rats, the most resistant strain to neuropathic pain.
Positive_regulation (upregulation) of Gene_expression (expression) of prodynorphin gene in DRG associated with neuropathic pain and sprains and strains
20) Confidence 0.63 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18472331 Disease Relevance 1.58 Pain Relevance 0.98

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