INT5594

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1982
Last Reported 2008
Negated 31
Speculated 19
Reported most in Abstract
Documents 137
Total Number 156
Disease Relevance 27.04
Pain Relevance 86.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn) plasma membrane (Pdyn)
Anatomy Link Frequency
striatum 21
hippocampus 17
nucleus accumbens 11
brain 9
hypothalamus 7
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 437 100.00 Very High Very High Very High
Enkephalin 265 100.00 Very High Very High Very High
cocaine 173 100.00 Very High Very High Very High
Morphine 141 100.00 Very High Very High Very High
Hippocampus 134 100.00 Very High Very High Very High
Opioid 125 100.00 Very High Very High Very High
narcan 47 100.00 Very High Very High Very High
substance P 28 100.00 Very High Very High Very High
Paracetamol 22 100.00 Very High Very High Very High
Neuropeptide 19 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 24 100.00 Very High Very High Very High
Endometriosis 10 100.00 Very High Very High Very High
Parkinson's Disease 8 100.00 Very High Very High Very High
Depression 6 100.00 Very High Very High Very High
Shock 12 99.98 Very High Very High Very High
Convulsion 127 99.82 Very High Very High Very High
Dyskinesias 5 99.82 Very High Very High Very High
Sprains And Strains 2 99.82 Very High Very High Very High
Diabetes Mellitus 13 99.68 Very High Very High Very High
Epilepsy 8 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that PDYN gene expression regulation by cocaine in the caudate putamen might be due to a combination of effects on two or three monoamine transporters, or to a mechanism unrelated to transporters inhibition.
Regulation (regulation) of PDYN gene in caudate putamen associated with monoamine and cocaine
1) Confidence 0.62 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15306127 Disease Relevance 0 Pain Relevance 0.58
Repeated imipramine administration (10 mg/kg i.p. twice daily for 10 days) had no effect on proenkephalin mRNA level, whereas the prodynorphin gene expression was regulated differently.
Neg (no) Regulation (effect) of proenkephalin mRNA
2) Confidence 0.62 Published 1997 Journal Pol J Pharmacol Section Abstract Doc Link 9566035 Disease Relevance 0 Pain Relevance 0.38
Imipramine induces alterations in proenkephalin and prodynorphin mRNAs level in the nucleus accumbens and striatum in the rat.
Regulation (alterations) of prodynorphin in nucleus accumbens associated with nucleus accumbens and enkephalin
3) Confidence 0.62 Published 1997 Journal Pol J Pharmacol Section Title Doc Link 9566035 Disease Relevance 0 Pain Relevance 0.59
In order to elucidate the activity of the endogenous prodynorphin system during opiate tolerance and dependence, we investigated the effect of single and repeated morphine administration on the alpha-neoendorphin tissue level, its in vitro release, and the prodynorphin messenger RNA level in the nucleus accumbens and striatum of the rat.
Spec (investigated) Regulation (effect) of alpha-neoendorphin in striatum associated with nucleus accumbens, addiction, tolerance, opiate and morphine
4) Confidence 0.62 Published 1996 Journal Neuroscience Section Abstract Doc Link 9045086 Disease Relevance 0 Pain Relevance 0.98
Early changes in prodynorphin mRNA and ir-dynorphin A levels after kindled seizures in the rat.
Regulation (changes) of ir-dynorphin associated with convulsion, dynorphin and enkephalin
5) Confidence 0.62 Published 1995 Journal Eur. J. Neurosci. Section Title Doc Link 8528458 Disease Relevance 0.61 Pain Relevance 0.66
Early changes in prodynorphin mRNA and ir-dynorphin A levels after kindled seizures in the rat.
Regulation (changes) of prodynorphin mRNA associated with convulsion, dynorphin and enkephalin
6) Confidence 0.62 Published 1995 Journal Eur. J. Neurosci. Section Title Doc Link 8528458 Disease Relevance 0.61 Pain Relevance 0.65
The objective of this study was to determine if prenatal cocaine affects the levels of prodynorphin and proenkephalin mRNA in male and female adolescent rats.
Regulation (affects) of proenkephalin mRNA associated with cocaine
7) Confidence 0.62 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17574751 Disease Relevance 0 Pain Relevance 0.30
Destruction of the dorsal raphe nucleus by microinjection of 5,7-dihydroxytryptamine failed to affect the levels of proenkephalin mRNA in any region.
Neg (failed) Regulation (affect) of proenkephalin mRNA in raphe nucleus associated with raphe
8) Confidence 0.62 Published 1988 Journal Brain Res. Section Abstract Doc Link 3179742 Disease Relevance 0 Pain Relevance 0.43
The effect of single and repeated (19 days) intragastric ethanol administration on prodynorphin mRNA and alpha-neoendorphin levels in the hippocampus of the rat was studied using in situ hybridization and RIA methods, respectively.
Regulation (effect) of alpha-neoendorphin in hippocampus associated with hippocampus
9) Confidence 0.62 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1589146 Disease Relevance 0 Pain Relevance 0.09
The effect of single and repeated (19 days) intragastric ethanol administration on prodynorphin mRNA and alpha-neoendorphin levels in the hippocampus of the rat was studied using in situ hybridization and RIA methods, respectively.
Regulation (effect) of prodynorphin mRNA in hippocampus associated with hippocampus
10) Confidence 0.62 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1589146 Disease Relevance 0 Pain Relevance 0.09
The effect of hippocampal kindling on the levels of prodynorphin mRNA in rat hippocampus was examined by in situ hybridization using a synthetic oligonucleotide probe.
Regulation (effect) of prodynorphin mRNA in hippocampus associated with hippocampus
11) Confidence 0.62 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3683985 Disease Relevance 0.08 Pain Relevance 0.05
To determine whether serotonin plays a role in the regulation of prodynorphin mRNA by kappa-opioid agonists or cocaine, rats were treated with the serotonin depleter parachloroamphetamine (PCA).
Spec (whether) Regulation (regulation) of prodynorphin mRNA associated with mu agonist, serotonin and cocaine
12) Confidence 0.61 Published 2007 Journal Neuroscience Section Abstract Doc Link 17055175 Disease Relevance 0 Pain Relevance 1.14
In contrast, the levels of prodynorphin mRNA were not significantly affected in any region.
Neg (not) Regulation (affected) of prodynorphin mRNA
13) Confidence 0.61 Published 1988 Journal Neuroscience Section Abstract Doc Link 3041310 Disease Relevance 0 Pain Relevance 0.25
Dopaminergic regulation of striatal proenkephalin mRNA and prodynorphin mRNA: contrasting effects of D1 and D2 antagonists.
Regulation (regulation) of proenkephalin mRNA associated with antagonist and enkephalin
14) Confidence 0.61 Published 1988 Journal Neuroscience Section Title Doc Link 3041310 Disease Relevance 0 Pain Relevance 0.34
Dopaminergic regulation of striatal proenkephalin mRNA and prodynorphin mRNA: contrasting effects of D1 and D2 antagonists.
Regulation (regulation) of prodynorphin mRNA associated with antagonist and enkephalin
15) Confidence 0.61 Published 1988 Journal Neuroscience Section Title Doc Link 3041310 Disease Relevance 0 Pain Relevance 0.35
In this study, the kinetics of the seizure-induced changes in prodynorphin mRNA and ir-dynorphin A levels in the hippocampus have been compared with those induced in the temporal and frontal cortex, i.e., in other regions involved in the pathophysiology of complex partial seizures.
Regulation (changes) of prodynorphin in frontal cortex associated with convulsion, dynorphin, urological neuroanatomy, hippocampus and partial seizures
16) Confidence 0.61 Published 1999 Journal J. Mol. Neurosci. Section Abstract Doc Link 10691294 Disease Relevance 0.74 Pain Relevance 0.43
Region-specific changes in prodynorphin mRNA and ir-dynorphin A levels after kindled seizures.
Regulation (changes) of prodynorphin associated with convulsion, dynorphin and enkephalin
17) Confidence 0.61 Published 1999 Journal J. Mol. Neurosci. Section Title Doc Link 10691294 Disease Relevance 0.73 Pain Relevance 0.59
The PDYN mRNA level was significantly elevated only in the hippocampus of epileptic rats, whereas age- or strain-related changes in the striatal and cortical PDYN mRNA levels were found in both epileptic and non-epileptic rats.
Regulation (changes) of PDYN mRNA in hippocampus associated with epilepsy, hippocampus and sprains and strains
18) Confidence 0.61 Published 1994 Journal Neuropeptides Section Abstract Doc Link 7898641 Disease Relevance 0.83 Pain Relevance 0.14
Repeated cocaine administration (20 mg/kg ip every hour for 3 h, for 5 days) had no effect on the proenkephalin and prodynorphin mRNA in the central nucleus of the amygdala.
Neg (no) Regulation (effect) of prodynorphin in amygdala associated with amygdala and cocaine
19) Confidence 0.60 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12523490 Disease Relevance 0.15 Pain Relevance 0.87
Striatal c-fos induction was blocked by local administration of phosphorothioated c-fos antisense oligonucleotides (AS-ODN) to examine the possible role of caffeine-induced c-fos expression in transcriptional regulation of striatal preproenkephalin, prodynorphin, preprotachykinin A and neurotensin/neuromedin N.
Regulation (regulation) of prodynorphin
20) Confidence 0.60 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9421173 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox