INT55944

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Context Info
Confidence 0.57
First Reported 1994
Last Reported 2010
Negated 9
Speculated 6
Reported most in Abstract
Documents 214
Total Number 220
Disease Relevance 105.14
Pain Relevance 81.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
skin 7
spinal 5
stomach 5
spinal cord 4
HGF 4
Cpox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 571 100.00 Very High Very High Very High
cytokine 341 100.00 Very High Very High Very High
agonist 313 100.00 Very High Very High Very High
COX2 312 100.00 Very High Very High Very High
COX-2 inhibitor 175 100.00 Very High Very High Very High
cOX1 137 100.00 Very High Very High Very High
aspirin 127 100.00 Very High Very High Very High
Inflammatory response 61 100.00 Very High Very High Very High
Endogenous opioid 12 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 3 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1483 100.00 Very High Very High Very High
Disease 340 100.00 Very High Very High Very High
Cancer 145 100.00 Very High Very High Very High
Urological Neuroanatomy 21 100.00 Very High Very High Very High
Functional Bowel Disorder 7 100.00 Very High Very High Very High
Apoptosis 93 99.90 Very High Very High Very High
Ganglion Cysts 36 99.84 Very High Very High Very High
Burns 15 99.84 Very High Very High Very High
Colorectal Cancer 6 99.84 Very High Very High Very High
Stress 141 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the inhibitory effect of paracetamol and caffeine on lipopolysaccharide (LPS)-induced cyclooxygenase (COX)- and prostaglandin (PG)E(2)-synthesis in primary rat microglial cells and compared it with the effect of acetylsalicylic acid, salicylic acid, and dipyrone.
Positive_regulation (induced) of COX in microglial cells associated with aspirin and paracetamol
1) Confidence 0.57 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10963764 Disease Relevance 0 Pain Relevance 0.84
Twenty-five weeks after the initiation of NMBA treatment, we observed an elevation in COX mRNA and protein expression and prostaglandin E(2) production in NMBA-treated esophageal tissues compared with normal epithelium.
Positive_regulation (elevation) of COX mRNA in epithelium
2) Confidence 0.47 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12154043 Disease Relevance 0.30 Pain Relevance 0.05
These findings reveal a novel mechanism by which elevated levels of spinal dynorphin seen in pathological conditions may produce hyperalgesia through the release of excitatory amino acids and in part by the activation of a constitutive spinal COX-1 and -2 cascade.
Positive_regulation (activation) of COX in spinal associated with hyperalgesia, dynorphin and excitatory amino acid
3) Confidence 0.46 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14960618 Disease Relevance 0.20 Pain Relevance 0.83
COX-2 is up-regulated in the stomach of arthritic rats, and PGs produced by COX-2 play a role in maintaining the integrity of the gastric mucosa.
Positive_regulation (up-regulated) of COX in stomach associated with arthritis
4) Confidence 0.45 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12388629 Disease Relevance 0.79 Pain Relevance 0.20
COX-2 is upregulated in several adult epithelial cancers.
Positive_regulation (upregulated) of COX associated with cancer
5) Confidence 0.44 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15975708 Disease Relevance 0.71 Pain Relevance 0.29
In arthritic rat stomachs, cyclooxygenase (COX)-2 was also up-regulated, where COX-2 selective inhibitors such as rofecoxib or celecoxib provoked gross lesions, although they caused no damage in normal rats.
Positive_regulation (up-regulated) of COX in stomachs associated with arthritis
6) Confidence 0.43 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12083738 Disease Relevance 1.06 Pain Relevance 0.55
Tumours from animals treated with vehicle or celecoxib expressed significantly elevated levels of COX-2 mRNA in comparison with the adjacent normal mucosa.
Positive_regulation (elevated) of COX associated with cancer
7) Confidence 0.40 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 1.06 Pain Relevance 0.47
However, COX-1SV mRNA levels were elevated in colorectal tumours and reduced after NSAID treatment to the levels observed in normal colonic mucosa.
Positive_regulation (elevated) of COX associated with colorectal cancer and cinod
8) Confidence 0.40 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11375891 Disease Relevance 0.81 Pain Relevance 0.34
Although the induction of COX-2 mRNA was inhibited by 2 Hz EA at various intensities, there was no significant change.
Positive_regulation (induction) of COX associated with electroacupuncture
9) Confidence 0.40 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 15942684 Disease Relevance 0.73 Pain Relevance 0.78
At 3 h after carrageenan-injection, we investigated whether the effects of a 2 Hz EA on a carrageenan-induced edema and hyperalgesia are associated with peripheral cyclooxygenase (COX) mRNA induction and prostaglandin E2 (PGE2) synthesis.
Spec (whether) Positive_regulation (induction) of COX in PGE2 associated with pressure and volume under development, hyperalgesia and electroacupuncture
10) Confidence 0.40 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 15942684 Disease Relevance 0.75 Pain Relevance 0.78
Vitamin D3 and tamoxifen, however, not only stimulate the release of AA from cells: they amplify rather than inhibits induced COX activity.
Positive_regulation (induced) of COX
11) Confidence 0.40 Published 2003 Journal FASEB J. Section Abstract Doc Link 12724337 Disease Relevance 0.48 Pain Relevance 0.21
Maximal up-regulation of COX-2 protein was detected at 6 h and was accompanied by increase of PGE(2) synthesis but not PGD(2).
Positive_regulation (up-regulation) of COX
12) Confidence 0.39 Published 2005 Journal Int. Immunopharmacol. Section Abstract Doc Link 15652766 Disease Relevance 0.26 Pain Relevance 0.09
Celecoxib reduced the elevated PGE(2) levels in brain of kainate-treated rats and inhibited induced COX activity, demonstrating the ability of this compound to act on COX-2 in CNS.
Positive_regulation (induced) of COX in CNS associated with central nervous system
13) Confidence 0.37 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183639 Disease Relevance 0.26 Pain Relevance 0.44
Northern blot analysis confirmed induction of COX-2 mRNA by LPS treatment.
Positive_regulation (induction) of COX
14) Confidence 0.36 Published 1998 Journal Inflamm. Res. Section Body Doc Link 9657255 Disease Relevance 0 Pain Relevance 0
Recent in vitro studies, clinical trials and epidemiological studies have suggested possible interactions between aspirin and other cyclo-oxygenase (COX) inhibitors, such as ibuprofen of the COX-2 inhibitors celecoxib and rofecoxib.
Positive_regulation (ibuprofen) of COX associated with aspirin and cox-2 inhibitor
15) Confidence 0.35 Published 2004 Journal Fundam Clin Pharmacol Section Abstract Doc Link 15482377 Disease Relevance 0.34 Pain Relevance 0.37
These data suggest that not only COX-2 but also COX-1 inhibition is required for protection against inflammatory changes in liver and small intestine following burn injury.
Positive_regulation (required) of COX in liver associated with inflammation, burns and injury
16) Confidence 0.35 Published 2002 Journal Burns Section Abstract Doc Link 11996850 Disease Relevance 0.86 Pain Relevance 0.13
After nerve injury, cyclooxygenase-2 (COX-2) is upregulated in spinal cord and peripheral nerve, the latter being dependent on tumor necrosis factor-alpha (TNF).
Positive_regulation (upregulated) of COX in peripheral nerve associated with necrosis, nervous system injury, cancer and spinal cord
17) Confidence 0.34 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 14697327 Disease Relevance 0.87 Pain Relevance 0.41
We also observed induction of COX-2 protein in the rat bladder tumor.
Positive_regulation (induction) of COX in bladder associated with bladder cancer
18) Confidence 0.34 Published 2003 Journal Aktuelle Urol Section Abstract Doc Link 14566678 Disease Relevance 1.29 Pain Relevance 0.33
By Western blot analysis, COX-2 and PGEs were induced in total brain, hippocampus, and cortex, but not in the spinal cord.
Neg (not) Positive_regulation (induced) of COX in spinal cord associated with hippocampus and spinal cord
19) Confidence 0.32 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183639 Disease Relevance 0.33 Pain Relevance 0.48
It has been suggested that nitric oxide (NO) stimulates the cyclooxygenase (COX)-dependent mechanisms in the ocular vasculature; however, the importance of the pathway in regulating retinal circulation in vivo remains to be elucidated.
Positive_regulation (stimulates) of COX in ocular vasculature
20) Confidence 0.32 Published 2009 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 19625688 Disease Relevance 0.08 Pain Relevance 0.07

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