INT55952

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Context Info
Confidence 0.61
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 12.14
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
colon 1
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 21 99.72 Very High Very High Very High
cytokine 36 99.68 Very High Very High Very High
Arthritis 106 96.72 Very High Very High Very High
agonist 1 87.84 High High
Inflammation 58 85.20 High High
chemokine 8 77.76 Quite High
cINOD 2 77.52 Quite High
metalloproteinase 5 69.04 Quite High
Nicotine 1 53.76 Quite High
Inflammatory response 8 43.52 Quite Low
Disease Link Frequency Relevance Heat
Cancer 363 100.00 Very High Very High Very High
Apoptosis 118 100.00 Very High Very High Very High
Ataxia 1 100.00 Very High Very High Very High
Osteogenic Sarcomas 52 99.82 Very High Very High Very High
Colon Cancer 25 99.54 Very High Very High Very High
Noninfiltrating Intraductal Carcinoma 9 99.32 Very High Very High Very High
Inflammatory Breast Neoplasms 114 99.04 Very High Very High Very High
Disease 90 97.92 Very High Very High Very High
Adhesions 15 97.60 Very High Very High Very High
Shock 2 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such a correlation was not demonstrated for HER2, Top IIa, Ki 67 or p53.
Neg (not) Transcription (demonstrated) of p53
1) Confidence 0.61 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410751 Disease Relevance 0.64 Pain Relevance 0
Previous studies from our laboratory have identified a number of miRNAs that were deregulated in colon cancer cell lines due to the deletion of the p53 tumor suppressor gene.
Transcription (deletion) of p53 in colon associated with cancer and colon cancer
2) Confidence 0.57 Published 2006 Journal Biomark Insights Section Abstract Doc Link PMC2134920 Disease Relevance 0.43 Pain Relevance 0
These events were associated with rapid co-ordinated transcription of pro-apoptotic genes including Fas/CD95, Bcl-2 and caspase families and ataxia telangiectasia mutated (ATM)/CHK2/p53 DNA damage response pathway.
Transcription (transcription) of p53 associated with ataxia and apoptosis
3) Confidence 0.52 Published 2009 Journal Carcinogenesis Section Abstract Doc Link 19502594 Disease Relevance 1.03 Pain Relevance 0.57
Hydralazine and magnesium valproate induced 7.7-fold p53 expression, which confirms that HDACs can up-regulate p53 gene transcription, as demonstrated with depsipeptide and trichostatin A [59], [60].
Transcription (transcription) of p53
4) Confidence 0.51 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762324 Disease Relevance 0.21 Pain Relevance 0
We identify 5 transcription factors in the global interaction network: FOS, FOXO1, NFAT5, NFKB1 and TP53.
Transcription (transcription) of TP53
5) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 1.25 Pain Relevance 0.38
The peptide sequences were derived from human HSP89 alpha, P53 and MBP.
Transcription (derived) of P53
6) Confidence 0.45 Published 1994 Journal Immunogenetics Section Abstract Doc Link 8039827 Disease Relevance 0 Pain Relevance 0
In an attempt to correlate p53 status with prognosis, the analysis was extended by an additional group of 24 IBC patients, who were screened for p53 mutations, p53 mRNA levels, and protein expression [32].
Transcription (levels) of p53 associated with inflammatory breast neoplasms
7) Confidence 0.45 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 0.81 Pain Relevance 0
We found a correlation between p53, p21 mRNA expression and NF-kappaB activation and, we observed an induction of heat shock protein 70 expression with a large decrease in caspase-3 activity after 100 microM NS-398 treatment.
Transcription (expression) of p53 associated with shock
8) Confidence 0.40 Published 2002 Journal Int. J. Oncol. Section Abstract Doc Link 12012007 Disease Relevance 0.75 Pain Relevance 0.15
Several PSGs identified here are associated with both FAS/p53 apoptosis and cancer (Da Fonseca et al., in prep.), such as the protein p53, which also regulates maternal reproduction [38]; the cell adhesion gene ADAM2 (P?
Transcription (apoptosis) of p53 associated with cancer, apoptosis and adhesions
9) Confidence 0.26 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2483296 Disease Relevance 0.88 Pain Relevance 0
Several PSGs identified here are associated with both FAS/p53 apoptosis and cancer (Da Fonseca et al., in prep.), such as the protein p53, which also regulates maternal reproduction [38]; the cell adhesion gene ADAM2 (P?
Transcription (apoptosis) of p53 associated with cancer, apoptosis and adhesions
10) Confidence 0.26 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2483296 Disease Relevance 0.89 Pain Relevance 0
The second gene associated with OS was the p53 gene where the mutations in the p53 gene were first observed in sporadic OS [8, 9].
Transcription (observed) of p53 associated with osteogenic sarcomas
11) Confidence 0.25 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC3020523 Disease Relevance 1.55 Pain Relevance 0
Eight patients (73%) had a p53 mutation; serial biopsies showed increases in p53 mRNA and p21 (WAF1/Cip1 mRNA).
Transcription (mRNA) of p53
12) Confidence 0.24 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.48 Pain Relevance 0
It was found that CAP enhanced the transcripts of two proto-oncogenes (c-myc and c-Ha-ras) and tumor suppressor gene p53.
Transcription (transcripts) of p53 associated with qutenza and cancer
13) Confidence 0.19 Published 1997 Journal Cancer Lett. Section Abstract Doc Link 9461043 Disease Relevance 0.99 Pain Relevance 0.96
Furthermore, DCIS frequently overexpresses mutated p53, HER-2/neu,
Transcription (neu) of p53 associated with noninfiltrating intraductal carcinoma
14) Confidence 0.13 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 1.63 Pain Relevance 0
EGR-1 regulates both proinflammatory cytokine activation and p53 transcription [14,15].
Transcription (transcription) of p53 associated with cytokine
15) Confidence 0.12 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2082467 Disease Relevance 0.21 Pain Relevance 0.28
Amongst the non-histone acetylation targets that via HDACi induced acetylation could potentially impart anti-cancer effect are transcription factors (p53, c-Myc, Smad7, BCL6, GATA, STAT3, NF-?
Transcription (transcription) of p53 associated with cancer
16) Confidence 0.09 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.37 Pain Relevance 0.03

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