INT5596

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Context Info
Confidence 0.59
First Reported 1984
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 41
Total Number 41
Disease Relevance 5.34
Pain Relevance 24.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn) plasma membrane (Pdyn)
Anatomy Link Frequency
hippocampus 7
hypothalamus 7
striatum 6
caudate-putamen 6
dentate gyrus 4
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 78 100.00 Very High Very High Very High
Enkephalin 72 100.00 Very High Very High Very High
cocaine 60 100.00 Very High Very High Very High
Hippocampus 36 100.00 Very High Very High Very High
Morphine 30 100.00 Very High Very High Very High
Pain 6 100.00 Very High Very High Very High
agonist 26 99.98 Very High Very High Very High
analgesia 4 99.98 Very High Very High Very High
Norepinephrine uptake inhibitor 4 99.98 Very High Very High Very High
opiate 5 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 6 100.00 Very High Very High Very High
Stress 2 100.00 Very High Very High Very High
Convulsion 8 99.88 Very High Very High Very High
Bone Cancer 2 99.48 Very High Very High Very High
Sprains And Strains 9 99.36 Very High Very High Very High
Cv General 4 Under Development 2 98.92 Very High Very High Very High
INFLAMMATION 4 98.84 Very High Very High Very High
Neuropathic Pain 6 98.48 Very High Very High Very High
Hyperalgesia 8 98.16 Very High Very High Very High
Cancer Pain 4 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was also reported that morphine decreased the prodynorphin gene expression in the rat hippocampus, striatum and hypothalamus.
Negative_regulation (decreased) of Gene_expression (expression) of prodynorphin in striatum associated with hippocampus and morphine
1) Confidence 0.59 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16861108 Disease Relevance 0.10 Pain Relevance 1.16
Both continuous infusions and daily injections of GBR 12909 produced significant decreases in prodynorphin expression in the hypothalamus (37% and 31% decreases, respectively).
Negative_regulation (decreases) of Gene_expression (expression) of prodynorphin in hypothalamus
2) Confidence 0.59 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11226394 Disease Relevance 0 Pain Relevance 0.23
This is in contrast to the tonic suppression of proenkephalin gene expression mediated by the mesostriatal dopamine pathway.
Negative_regulation (suppression) of Gene_expression (expression) of proenkephalin gene associated with dopamine
3) Confidence 0.59 Published 1988 Journal Brain Res. Section Abstract Doc Link 3179742 Disease Relevance 0 Pain Relevance 0.42
Since destruction of the mesostriatal dopamine system elevates the levels of proenkephalin mRNA, but not of prodynorphin mRNA, in the striatal target neurons, it appears that the mesostriatal pathway exerts a tonic and selective suppression of striatal proenkephalin gene expression at the mRNA level.
Negative_regulation (suppression) of Gene_expression (expression) of proenkephalin gene in neurons associated with dopamine
4) Confidence 0.59 Published 1989 Journal J. Mol. Neurosci. Section Abstract Doc Link 2561993 Disease Relevance 0 Pain Relevance 0.44
These results suggest that EA alleviates bone cancer pain at least in part by suppressing dynorphin expression, and they support the clinical use of EA in the treatment of cancer pain.
Negative_regulation (suppressing) of Gene_expression (expression) of dynorphin associated with dynorphin, cancer pain, electroacupuncture and bone cancer
5) Confidence 0.58 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18221900 Disease Relevance 1.15 Pain Relevance 1.36
These results indicate that activation of the perforant path inhibits the gene expression of prodynorphin, but enhances that of proenkephalin in the entorhinal cortex-hippocampal region.
Negative_regulation (inhibits) of Gene_expression (expression) of prodynorphin in cortex
6) Confidence 0.57 Published 1990 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1970844 Disease Relevance 0.06 Pain Relevance 0.42
Nitric oxide synthase inhibitor L-NAME prevents amphetamine-induced prodynorphin gene expression in the rat.
Negative_regulation (prevents) of Gene_expression (expression) of prodynorphin gene associated with enkephalin
7) Confidence 0.55 Published 1996 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Title Doc Link 8938822 Disease Relevance 0 Pain Relevance 0.32
The intermittent morphine treatment resulted in an initial decrease of preprodynorphin gene expression of about 5-10% in the caudate-putamen and the nucleus accumbens at the rostral and intermediate levels one day after the last morphine administration.
Negative_regulation (decrease) of Gene_expression (expression) of preprodynorphin gene in caudate-putamen associated with nucleus accumbens and morphine
8) Confidence 0.55 Published 1997 Journal Neuroscience Section Abstract Doc Link 8971769 Disease Relevance 0 Pain Relevance 1.26
There were also significant 6-OHDA-induced decreases in Pdyn expression in the SL group (Figure 3C).
Negative_regulation (decreases) of Gene_expression (expression) of Pdyn
9) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.18
In addition, we found a significant downregulation of tyrosine hydroxylase and proenkephalin gene expression levels in both strains whereas delta-opioid receptor was found to be significantly downregulated only in injured DRG of Lewis rats although the same trend was observed in F344 rats.
Negative_regulation (downregulation) of Gene_expression (expression) of proenkephalin gene in DRG associated with opioid receptor and sprains and strains
10) Confidence 0.53 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18472331 Disease Relevance 1.49 Pain Relevance 0.93
As previously reported, continuous infusion of cocaine for seven days or GBR 12909, a selective dopamine uptake inhibitor, produced significant decreases in prodynorphin (PDYN) gene expression in the hypothalamus.
Negative_regulation (decreases) of Gene_expression (expression) of PDYN in hypothalamus associated with dopamine and cocaine
11) Confidence 0.51 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15306127 Disease Relevance 0 Pain Relevance 0.59
In contrast, in the hippocampus, the decrease in prodynorphin mRNA produced by U-69593 was no longer evident after PCA and cocaine, which previously had no effect, now increased it in the serotonin-depleted group.
Negative_regulation (decrease) of Gene_expression (produced) of prodynorphin mRNA in hippocampus associated with hippocampus, serotonin and cocaine
12) Confidence 0.51 Published 2007 Journal Neuroscience Section Abstract Doc Link 17055175 Disease Relevance 0 Pain Relevance 1.04
Both continuous infusions and daily injections of GBR 12909 produced significant decreases in prodynorphin expression in the hypothalamus (37% and 31% decreases, respectively).
Negative_regulation (decreases) of Gene_expression (expression) of prodynorphin in hypothalamus
13) Confidence 0.43 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11226394 Disease Relevance 0 Pain Relevance 0.24
Conversely, the lesion caused a persistent decrease in the levels of prodynorphin mRNA in the nucleus accumbens and a small and transient decrease in the caudate-putamen.
Negative_regulation (decrease) of Gene_expression (levels) of prodynorphin mRNA in nucleus accumbens associated with nucleus accumbens
14) Confidence 0.43 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1312205 Disease Relevance 0 Pain Relevance 0.24
The levels of prodynorphin mRNA in the ipsilateral caudate-putamen decreased 20% below control and returned to control levels 4 and 8 weeks post-lesion.
Negative_regulation (decreased) of Gene_expression (levels) of prodynorphin mRNA in caudate-putamen
15) Confidence 0.43 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1312205 Disease Relevance 0 Pain Relevance 0.20
Levels of prodynorphin mRNA in rat dentate gyrus are decreased during hippocampal kindling.
Negative_regulation (decreased) of Gene_expression (Levels) of prodynorphin mRNA in dentate gyrus associated with enkephalin
16) Confidence 0.43 Published 1987 Journal Neurosci. Lett. Section Title Doc Link 3683985 Disease Relevance 0.08 Pain Relevance 0.15
In rats exhibiting stage 4 seizures, the levels of prodynorphin mRNA in the dentate gyrus were dramatically reduced compared to control animals.
Negative_regulation (reduced) of Gene_expression (levels) of prodynorphin mRNA in dentate gyrus associated with convulsion
17) Confidence 0.43 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3683985 Disease Relevance 0.10 Pain Relevance 0.04
Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene expression in rat CNS.
Negative_regulation (nisoxetine) of Gene_expression (expression) of prodynorphin gene associated with norepinephrine uptake inhibitor and enkephalin
18) Confidence 0.43 Published 2004 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 15306127 Disease Relevance 0 Pain Relevance 0.79
The levels of prodynorphin mRNA were unaffected by SCH 23390 treatment in all regions examined.
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (levels) of prodynorphin mRNA
19) Confidence 0.43 Published 1988 Journal Neuroscience Section Abstract Doc Link 3041310 Disease Relevance 0 Pain Relevance 0.26
We hypothesized that proDynorphin gene expression in brain areas involved in taste and feeding declines with age.
Negative_regulation (declines) of Gene_expression (expression) of proDynorphin in brain
20) Confidence 0.43 Published 2004 Journal Neurobiol. Aging Section Abstract Doc Link 15465632 Disease Relevance 0 Pain Relevance 0.15

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