INT55961

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Context Info
Confidence 0.68
First Reported 1994
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 9.39
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maob) oxidoreductase activity (Maob)
Anatomy Link Frequency
platelet 4
brainstem 1
Maob (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 2 99.06 Very High Very High Very High
Inflammation 8 97.88 Very High Very High Very High
cerebral cortex 1 97.28 Very High Very High Very High
monoamine 52 85.76 High High
addiction 48 81.76 Quite High
alcohol 8 81.32 Quite High
Nicotine 16 80.80 Quite High
anesthesia 1 74.56 Quite High
Serotonin 24 49.36 Quite Low
antidepressant 8 14.48 Low Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 1368 99.98 Very High Very High Very High
INFLAMMATION 8 97.88 Very High Very High Very High
Hyperammonemia 1 92.20 High High
Cancer 24 90.12 High High
Lung Cancer 24 86.60 High High
Colon Cancer 8 82.24 Quite High
Suicidal Behaviour 8 68.80 Quite High
Cardiovascular Disorder Under Development 16 48.80 Quite Low
Atherosclerosis 24 5.00 Very Low Very Low Very Low
Hypertension 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the persistent increase in MAO-B protein concentration, a study of the methylation of its gene promoter was undertaken in a small supplementary cohort of similar subjects.
Spec (investigate) Positive_regulation (increase) of MAO-B protein
1) Confidence 0.68 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2775922 Disease Relevance 1.55 Pain Relevance 0.10
This smoking-induced long-lasting effect was due to demethylation of the MAOB gene promoter which resulted in a persistent high protein concentration of platelet MAO-B.
Positive_regulation (concentration) of MAO-B in platelet associated with nicotine addiction
2) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 0.87 Pain Relevance 0
MAOA activities were decreased in cerebellum (by 23%, P < 0.05) and brainstem (by 16%, P < 0.05) of spf mice; activities of MAOB were concomitantly increased in cerebellum (by 22%, P < 0.05), brainstem (by 20%, P < 0.05) and cerebral cortex (by 22%, P < 0.05).
Positive_regulation (increased) of MAOB in brainstem associated with medulla and cerebral cortex
3) Confidence 0.60 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8041507 Disease Relevance 0.09 Pain Relevance 0.38
Both S and FS exhibited reduced methylation of the MAOB promoter, leading to a more active transcription of the gene and hence a greater protein concentration of MAO-B.
Positive_regulation (methylation) of MAOB associated with nicotine addiction
4) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.15 Pain Relevance 0.19
This smoking-induced long-lasting effect was due to demethylation of the MAOB gene promoter which resulted in a persistent high protein concentration of platelet MAO-B.
Positive_regulation (induced) of MAOB in platelet associated with nicotine addiction
5) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 0.90 Pain Relevance 0
The persistence of increased protein concentrations of MAO-B was unexpected, even though some haematological and inflammation characteristics remain modified for several years after quitting smoking [19], [35], [36].
Positive_regulation (increased) of MAO-B associated with nicotine addiction and inflammation
6) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.27 Pain Relevance 0.08
Here, the distinct measurement of MAO activities and of MAO protein concentrations shows that the FS group accounts for the significantly higher platelet MAO-B activity found in “current non-smokers”.
Positive_regulation (accounts) of MAO-B in platelet associated with nicotine addiction
7) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.14 Pain Relevance 0.03
Moreover, ex vivo animal experiments showed that tobacco smoke induced a reduction in the MAOB promoter methylation.
Positive_regulation (induced) of MAOB associated with nicotine addiction
8) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.13 Pain Relevance 0.14
The present results reassert that MAO-B activity is inhibited by smoking and reveal for the first time that (i) platelet MAO-B protein concentration increased during smoking and (ii) this increase lasted long after quitting smoking (13 yrs average in our FS group, Table 2).

5-HT Catabolism and Cardiovascular Risk

Positive_regulation (increased) of platelet MAO-B protein in platelet associated with nicotine addiction
9) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.28 Pain Relevance 0

General Comments

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