INT55962

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Context Info
Confidence 0.20
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 7.76
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PROC) extracellular space (PROC) extracellular region (PROC)
plasma membrane (PROC)
Anatomy Link Frequency
osteoclast 4
hepatocytes 2
colon 2
PROC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 28 100.00 Very High Very High Very High
cytokine 25 99.80 Very High Very High Very High
substance P 8 98.58 Very High Very High Very High
Pain 4 97.40 Very High Very High Very High
Neuropeptide 3 90.16 High High
c fibre 1 89.24 High High
Bile 11 88.60 High High
Inflammatory response 7 88.52 High High
qutenza 2 86.76 High High
imagery 2 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 34 100.00 Very High Very High Very High
Cancer 15 100.00 Very High Very High Very High
Colitis 7 100.00 Very High Very High Very High
Osteolysis 1 100.00 Very High Very High Very High
Hypercalcemia 12 99.84 Very High Very High Very High
Osteoporosis 6 99.52 Very High Very High Very High
Breast Cancer 13 98.74 Very High Very High Very High
Pain 6 97.40 Very High Very High Very High
Metastasis 19 97.36 Very High Very High Very High
Liver Cancer 2 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the process of bone metastasis, the primary mechanism responsible for bone destruction is cancer cell-mediated stimulation of osteoclastic bone resorption, which results in osteolysis and release of various growth factors from the bone matrix.
Positive_regulation (results) of Localization (release) of factors associated with cancer, osteolysis, hypercalcemia, osteoporosis and metastasis
1) Confidence 0.20 Published 2007 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 17220661 Disease Relevance 1.40 Pain Relevance 0.09
Tumor cells metastatic to bone can also secrete growth factors, leading to increased osteoblastic activity.
Positive_regulation (leading) of Localization (secrete) of factors associated with cancer and osteoporosis
2) Confidence 0.20 Published 2007 Journal Clin. Breast Cancer Section Abstract Doc Link 17683652 Disease Relevance 1.51 Pain Relevance 0.18
The colon is the preferred localization of PC, which is caused by the alteration in the bacterial population of the bowel which favors the growth and activation of several germ types--e.g., the Clostridium difficile, whose toxins can damage the colonic mucosa deeply.
Positive_regulation (caused) of Localization (localization) of PC in colon associated with colitis and clostridium difficile infection
3) Confidence 0.14 Published 1994 Journal Radiol Med Section Abstract Doc Link 8041931 Disease Relevance 0.94 Pain Relevance 0.16
This SP-mediated VCAM-1 induction appeared to be a direct effect that did not require the release of other HDMEC-derived soluble factors.
Neg (not) Positive_regulation (require) of Localization (release) of factors associated with substance p
4) Confidence 0.03 Published 1999 Journal J. Immunol. Section Abstract Doc Link 9973426 Disease Relevance 0.14 Pain Relevance 0.70
The ratio of ratio of PC per apoE at apoE concentrations of 0.1,1,10, and 30 ?
Positive_regulation (at) of Localization (ratio) of PC
5) Confidence 0.03 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.11 Pain Relevance 0
in the BF-induced activation of PC secretion in h-hepatocytes.
Positive_regulation (activation) of Localization (secretion) of PC in hepatocytes
6) Confidence 0.01 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.22 Pain Relevance 0.07
Bisphosphonates are potent inhibitors of osteoclast-mediated bone resorption, and it is well known that breast cancer cells in bone can stimulate osteoclast formation and activity leading to the release of growth factors and cytokines, which will further stimulate cancer cell growth and their secretion of osteolytic factors.
Positive_regulation (stimulate) of Localization (secretion) of factors in osteoclast associated with cancer, breast cancer, hypercalcemia and cytokine
7) Confidence 0.01 Published 2001 Journal J Mammary Gland Biol Neoplasia Section Abstract Doc Link 12013536 Disease Relevance 1.23 Pain Relevance 0.14
Bisphosphonates are potent inhibitors of osteoclast-mediated bone resorption, and it is well known that breast cancer cells in bone can stimulate osteoclast formation and activity leading to the release of growth factors and cytokines, which will further stimulate cancer cell growth and their secretion of osteolytic factors.
Positive_regulation (leading) of Localization (release) of factors in osteoclast associated with cancer, breast cancer, hypercalcemia and cytokine
8) Confidence 0.01 Published 2001 Journal J Mammary Gland Biol Neoplasia Section Abstract Doc Link 12013536 Disease Relevance 1.24 Pain Relevance 0.14
is able to induce the secretion of several inflammatory factors, such as IL-6, IL-8, TNF-?
Positive_regulation (induce) of Localization (secretion) of factors associated with inflammation
9) Confidence 0.01 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.99 Pain Relevance 0.41

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