INT5597

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Context Info
Confidence 0.78
First Reported 1983
Last Reported 2010
Negated 4
Speculated 21
Reported most in Abstract
Documents 433
Total Number 454
Disease Relevance 62.97
Pain Relevance 235.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn) plasma membrane (Pdyn)
Anatomy Link Frequency
brain 37
striatum 31
hippocampus 24
neurons 22
nucleus accumbens 22
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 1015 100.00 Very High Very High Very High
Enkephalin 734 100.00 Very High Very High Very High
Opioid 408 100.00 Very High Very High Very High
agonist 124 100.00 Very High Very High Very High
Neuropeptide 109 100.00 Very High Very High Very High
Pain 103 100.00 Very High Very High Very High
substance P 82 100.00 Very High Very High Very High
Dorsal horn 44 100.00 Very High Very High Very High
Analgesic 32 100.00 Very High Very High Very High
orphanin 22 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 12 100.00 Very High Very High Very High
Endometriosis 10 100.00 Very High Very High Very High
Sprains And Strains 23 99.98 Very High Very High Very High
INFLAMMATION 174 99.96 Very High Very High Very High
Convulsion 83 99.88 Very High Very High Very High
Neuropathic Pain 51 99.72 Very High Very High Very High
Pain 118 99.66 Very High Very High Very High
Dyskinesias 56 99.60 Very High Very High Very High
Arthritis 17 99.58 Very High Very High Very High
Vibrio Infection 28 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of the selective norepinephrine uptake inhibitor nisoxetine was examined on PDYN gene expression.
Spec (examined) Gene_expression (expression) of PDYN gene associated with norepinephrine uptake inhibitor
1) Confidence 0.78 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15306127 Disease Relevance 0 Pain Relevance 0.64
These findings suggest that PDYN gene expression regulation by cocaine in the caudate putamen might be due to a combination of effects on two or three monoamine transporters, or to a mechanism unrelated to transporters inhibition.
Gene_expression (expression) of PDYN gene in caudate putamen associated with monoamine and cocaine
2) Confidence 0.78 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15306127 Disease Relevance 0 Pain Relevance 0.58
Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene expression in rat CNS.
Gene_expression (expression) of prodynorphin gene associated with norepinephrine uptake inhibitor and enkephalin
3) Confidence 0.78 Published 2004 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 15306127 Disease Relevance 0 Pain Relevance 0.79
This treatment produced significant increases in PDYN gene expression in the hypothalamus (183% of control), nucleus accumbens (142% of control) and hippocampus (124% of control) and a significant decrease in the caudate putamen (69% of control).
Gene_expression (expression) of PDYN gene in hippocampus associated with nucleus accumbens and hippocampus
4) Confidence 0.78 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15306127 Disease Relevance 0 Pain Relevance 0.69
Thus, the inhibition of NE uptake alone cannot account for the cocaine-induced increase of PDYN gene expression.
Gene_expression (expression) of PDYN gene associated with cocaine
5) Confidence 0.78 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15306127 Disease Relevance 0 Pain Relevance 0.61
In this study, we evaluated effects of single and repeated imipramine administration on proenkephalin and prodynorphin gene expression in the rat nucleus accumbens and striatum.
Gene_expression (expression) of prodynorphin in striatum associated with nucleus accumbens
6) Confidence 0.78 Published 1997 Journal Pol J Pharmacol Section Abstract Doc Link 9566035 Disease Relevance 0 Pain Relevance 0.26
Repeated imipramine administration (10 mg/kg i.p. twice daily for 10 days) had no effect on proenkephalin mRNA level, whereas the prodynorphin gene expression was regulated differently.
Gene_expression (expression) of prodynorphin
7) Confidence 0.78 Published 1997 Journal Pol J Pharmacol Section Abstract Doc Link 9566035 Disease Relevance 0 Pain Relevance 0.39
Age-related changes in brain proDynorphin gene expression in the rat.
Gene_expression (expression) of proDynorphin in brain associated with enkephalin
8) Confidence 0.78 Published 2004 Journal Neurobiol. Aging Section Title Doc Link 15465632 Disease Relevance 0 Pain Relevance 0.29
We hypothesized that proDynorphin gene expression in brain areas involved in taste and feeding declines with age.
Gene_expression (expression) of proDynorphin in brain
9) Confidence 0.78 Published 2004 Journal Neurobiol. Aging Section Abstract Doc Link 15465632 Disease Relevance 0 Pain Relevance 0.12
It was also reported that morphine decreased the prodynorphin gene expression in the rat hippocampus, striatum and hypothalamus.
Gene_expression (expression) of prodynorphin in striatum associated with hippocampus and morphine
10) Confidence 0.78 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16861108 Disease Relevance 0.10 Pain Relevance 1.16
In this study, we determined the prodynorphin gene expression and dynorphin levels in selected brain regions of opioid tolerant rats.
Spec (determined) Gene_expression (expression) of prodynorphin in brain associated with dynorphin and opioid
11) Confidence 0.78 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16861108 Disease Relevance 0.09 Pain Relevance 1.30
In nucleus accumbens and the temporal-parietal cortex the changes in the prodynorphin gene expression and the dynorphin levels did not correlate.
Gene_expression (expression) of prodynorphin in parietal cortex associated with nucleus accumbens and dynorphin
12) Confidence 0.78 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16861108 Disease Relevance 0.05 Pain Relevance 1.65
We found that in the striatum morphine decreased, while oxycodone-6-oxime increased and 14-methoxymetopon did not alter the prodynorphin gene expression.
Gene_expression (expression) of prodynorphin in striatum associated with oxycodone and morphine
13) Confidence 0.78 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16861108 Disease Relevance 0.08 Pain Relevance 1.57
In the nucleus accumbens, morphine and oxycodone-6-oxime did not change, while 14-methoxymetopon increased the prodynorphin gene expression.
Gene_expression (expression) of prodynorphin in nucleus accumbens associated with oxycodone, nucleus accumbens and morphine
14) Confidence 0.78 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16861108 Disease Relevance 0.08 Pain Relevance 1.66
Alterations in prodynorphin gene expression and dynorphin levels in different brain regions after chronic administration of 14-methoxymetopon and oxycodone-6-oxime.
Gene_expression (expression) of prodynorphin in brain associated with oxycodone, dynorphin and enkephalin
15) Confidence 0.78 Published 2006 Journal Brain Res. Bull. Section Title Doc Link 16861108 Disease Relevance 0.09 Pain Relevance 1.62
In the hippocampus both oxycodone-6-oxime and 14-methoxymetopon enhanced, whereas morphine did not alter the prodynorphin gene expression.
Gene_expression (expression) of prodynorphin in hippocampus associated with oxycodone, hippocampus and morphine
16) Confidence 0.78 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16861108 Disease Relevance 0.07 Pain Relevance 1.74
Role of serotonin on cocaine-mediated effects on prodynorphin gene expression in the rat brain.
Gene_expression (expression) of prodynorphin in brain associated with enkephalin, serotonin and cocaine
17) Confidence 0.78 Published 2004 Journal J. Mol. Neurosci. Section Title Doc Link 14997015 Disease Relevance 0 Pain Relevance 0.94
Because we previously reported that continuous infusion of cocaine for 7 d (which inhibits dopamine, serotonin, and norepinephrine uptake), or GBR 12909 (a selective dopamine uptake inhibitor), produced significant decreases in the hypothalamus and cocaine also produced a significant increase in prodynorphin gene expression in caudate putamen, regulation of prodynorphin gene expression by fluoxetine is suggested to be different from that by cocaine.
Gene_expression (expression) of prodynorphin in caudate putamen associated with dopamine, serotonin, fluoxetine and cocaine
18) Confidence 0.78 Published 2004 Journal J. Mol. Neurosci. Section Abstract Doc Link 14997015 Disease Relevance 0 Pain Relevance 1.05
Thus, chronic inhibition of serotonin uptake can regulate prodynorphin gene expression in the hypothalamus, caudate putamen, and nucleus accumbens.
Gene_expression (expression) of prodynorphin in nucleus accumbens associated with nucleus accumbens and serotonin
19) Confidence 0.78 Published 2004 Journal J. Mol. Neurosci. Section Abstract Doc Link 14997015 Disease Relevance 0 Pain Relevance 0.85
Because we previously reported that continuous infusion of cocaine for 7 d (which inhibits dopamine, serotonin, and norepinephrine uptake), or GBR 12909 (a selective dopamine uptake inhibitor), produced significant decreases in the hypothalamus and cocaine also produced a significant increase in prodynorphin gene expression in caudate putamen, regulation of prodynorphin gene expression by fluoxetine is suggested to be different from that by cocaine.
Gene_expression (expression) of prodynorphin in caudate putamen associated with dopamine, serotonin, fluoxetine and cocaine
20) Confidence 0.78 Published 2004 Journal J. Mol. Neurosci. Section Abstract Doc Link 14997015 Disease Relevance 0 Pain Relevance 1.06

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