INT55975

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Context Info
Confidence 0.31
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.44
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sciatic nerves 2
duodenum 2
stomach 2
Lpo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 3 100.00 Very High Very High Very High
ischemia 1 99.16 Very High Very High Very High
Eae 3 98.12 Very High Very High Very High
Thermal hyperalgesia 6 95.32 Very High Very High Very High
Angina 1 86.88 High High
Neuronal nitric oxide synthase 1 81.60 Quite High
Somatostatin 56 77.32 Quite High
substance P 1 56.12 Quite High
Bile 4 39.60 Quite Low
Pain 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 142 99.84 Very High Very High Very High
Injury 12 98.12 Very High Very High Very High
Hyperalgesia 6 95.32 Very High Very High Very High
Disorder Of Lipid Metabolism 25 89.36 High High
Peripheral Arterial Disease 5 88.68 High High
Cv General 3 Under Development 1 86.88 High High
Stress 26 86.00 High High
Coronary Artery Disease 7 85.44 High High
Atherosclerosis 5 75.12 Quite High
Nervous System Injury 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of LPO in the injured sciatic nerves were significantly reduced using either early or late treatment, however tirilazad had opposing effects on recovery, prolonging or alleviating thermal hyperalgesia, respectively.
Negative_regulation (reduced) of Gene_expression (Levels) of LPO in sciatic nerves associated with thermal hyperalgesia and sciatic nerve
1) Confidence 0.31 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11498276 Disease Relevance 0.55 Pain Relevance 0.51
Concomitant treatment of rats with sulphated polysaccharides significantly (P < 0.001) reduced the elevated levels of LPO, 8-OHdG and protein carbonyl close to that of controls, thereby strongly confirming its potential in inhibiting the oxidation of macromolecules like lipids, DNA and proteins.


Negative_regulation (reduced) of Gene_expression (levels) of LPO
2) Confidence 0.30 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2291455 Disease Relevance 0.09 Pain Relevance 0
Administration of zinc sulfate was found to reduce stomach LPO levels in diabetic rats, but in the nondiabetic control groups, it significantly increased the stomach LPO levels (ap<0.0001).
Negative_regulation (reduce) of Gene_expression (levels) of LPO in stomach associated with diabetes mellitus
3) Confidence 0.30 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831851 Disease Relevance 0.62 Pain Relevance 0.07
In diabetic rats treated with zinc sulfate, the duodenum LPO levels decreased significantly when compared with the diabetic group (bp<0.0001).
Negative_regulation (decreased) of Gene_expression (levels) of LPO in duodenum associated with diabetes mellitus
4) Confidence 0.30 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1831851 Disease Relevance 1.33 Pain Relevance 0
Ligustrazine could reduce the production of LPO due to the accelerating clearance of oxygen free radical.
Negative_regulation (reduce) of Gene_expression (production) of LPO
5) Confidence 0.18 Published 1994 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Abstract Doc Link 8043996 Disease Relevance 0.23 Pain Relevance 0.14
Feeding with HFD produced an increased LPO in the group II animals (P<0.001), which was significantly reduced by the treatment with MEEV (200 and 400 mg/kg) in group III and IV animals, respectively [Table 2].
Negative_regulation (reduced) of Gene_expression (produced) of LPO
6) Confidence 0.14 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Body Doc Link PMC2996074 Disease Relevance 0.63 Pain Relevance 0

General Comments

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