INT5598

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Context Info
Confidence 0.59
First Reported 1981
Last Reported 2009
Negated 7
Speculated 3
Reported most in Abstract
Documents 95
Total Number 98
Disease Relevance 14.40
Pain Relevance 55.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn) plasma membrane (Pdyn)
Anatomy Link Frequency
striatum 12
hippocampus 12
caudate putamen 6
hypothalamus 6
dentate gyrus 5
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 224 100.00 Very High Very High Very High
Hippocampus 113 100.00 Very High Very High Very High
analgesia 9 100.00 Very High Very High Very High
fluoxetine 29 99.98 Very High Very High Very High
Spinal cord 19 99.98 Very High Very High Very High
Dextromethorphan 7 99.98 Very High Very High Very High
substance P 5 99.84 Very High Very High Very High
Enkephalin 176 99.80 Very High Very High Very High
Morphine 23 99.80 Very High Very High Very High
Glutamate 13 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 70 99.96 Very High Very High Very High
Sprains And Strains 12 99.84 Very High Very High Very High
Urological Neuroanatomy 11 99.28 Very High Very High Very High
Eating Disorder 4 98.82 Very High Very High Very High
Neuropathic Pain 7 98.48 Very High Very High Very High
Aggression 6 97.96 Very High Very High Very High
Arthritis 9 96.04 Very High Very High Very High
Parkinson's Disease 1 95.88 Very High Very High Very High
Drug Dependence 3 95.68 Very High Very High Very High
Nociception 2 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, nisoxetine, as well as fluoxetine, decreases PDYN mRNA in the caudate putamen, in contrast to the up-regulation produced by cocaine.
Negative_regulation (decreases) of PDYN mRNA in caudate putamen associated with cocaine and fluoxetine
1) Confidence 0.59 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15306127 Disease Relevance 0 Pain Relevance 0.73
Cocaine also produced a significant increase in PDYN mRNA in the caudate putamen, whereas GBR12909 has no effect and the selective serotonin uptake inhibitor fluoxetine decreases PDYN mRNA in the same brain region.
Negative_regulation (decreases) of PDYN mRNA in caudate putamen associated with serotonin, fluoxetine and cocaine
2) Confidence 0.59 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15306127 Disease Relevance 0 Pain Relevance 0.60
ProDynorphin mRNA (measured using a cDNA probe) decreased significantly with age in arcuate nucleus and amygdala; increased significantly with age in hippocampus; and was not significantly affected in nucleus of the solitary tract, cortex, caudate putamen or hypothalamic paraventricular nucleus.
Negative_regulation (decreased) of ProDynorphin in arcuate nucleus associated with hippocampus and amygdala
3) Confidence 0.59 Published 2004 Journal Neurobiol. Aging Section Abstract Doc Link 15465632 Disease Relevance 0 Pain Relevance 0.21
Conversely, the lesion caused a persistent decrease in the levels of prodynorphin mRNA in the nucleus accumbens and a small and transient decrease in the caudate-putamen.
Negative_regulation (decrease) of prodynorphin mRNA in nucleus accumbens associated with nucleus accumbens
4) Confidence 0.59 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1312205 Disease Relevance 0 Pain Relevance 0.24
In rats showing stage 3 kindled seizures, after consecutive stimulation of the right perforant path, a decrease in the level of prodynorphin mRNA and an increase in levels of proenkephalin mRNA in the ipsilateral hippocampus was found.
Negative_regulation (decrease) of prodynorphin mRNA in stage 3 associated with convulsion and hippocampus
5) Confidence 0.59 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 2325899 Disease Relevance 0.33 Pain Relevance 0.38
The highest dose of tramadol (80 mg/kg) decreased prodynorphin mRNA levels in the hypothalamus and the hippocampus but not in the striatum.
Negative_regulation (decreased) of prodynorphin mRNA in striatum associated with tramadol and hippocampus
6) Confidence 0.59 Published 2006 Journal J. Mol. Neurosci. Section Abstract Doc Link 17401159 Disease Relevance 0 Pain Relevance 1.62
While morphine caused a downregulation of prodynorphin mRNA levels in all investigated areas (hypothalamus, hippocampus, and striatum), tramadol did not cause any significant change in the striatum, and did not decrease prodynorphin biosynthesis in the hypothalamus and in the hippocampus, at nontoxic doses (10 and 20 mg/kg).
Spec (investigated) Negative_regulation (downregulation) of prodynorphin mRNA in hippocampus associated with tramadol, hippocampus and morphine
7) Confidence 0.59 Published 2006 Journal J. Mol. Neurosci. Section Abstract Doc Link 17401159 Disease Relevance 0 Pain Relevance 1.56
Intracerebroventricular (i.c.v.) infusion of cocaine hydrochloride (30 micrograms/day) for 7 days, by means of osmotic minipumps, elicited a significant 35% decrease of prodynorphin mRNA levels in rat hypothalamus and increase (22%) in caudate-putamen.
Negative_regulation (decrease) of prodynorphin mRNA in hypothalamus associated with intracerebroventricular and cocaine
8) Confidence 0.59 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8840025 Disease Relevance 0 Pain Relevance 0.50
In rats exhibiting stage 4 seizures, the levels of prodynorphin mRNA in the dentate gyrus were dramatically reduced compared to control animals.
Negative_regulation (reduced) of prodynorphin mRNA in dentate gyrus associated with convulsion
9) Confidence 0.59 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3683985 Disease Relevance 0.10 Pain Relevance 0.04
Levels of prodynorphin mRNA in rat dentate gyrus are decreased during hippocampal kindling.
Negative_regulation (decreased) of prodynorphin mRNA in dentate gyrus associated with enkephalin
10) Confidence 0.59 Published 1987 Journal Neurosci. Lett. Section Title Doc Link 3683985 Disease Relevance 0.08 Pain Relevance 0.15
Chronic intracerebroventricular treatment with the synthetic opioid agonist acting on the kappa receptor, U-50,488H, and the classic mu agonist morphine markedly decreased prodynorphin mRNA levels in hypothalamus, hippocampus and striatum of tolerant rats.
Negative_regulation (decreased) of prodynorphin mRNA in hippocampus associated with mu agonist, agonist, hippocampus, intracerebroventricular and morphine
11) Confidence 0.58 Published 1991 Journal Brain Res. Section Abstract Doc Link 1786525 Disease Relevance 0 Pain Relevance 0.77
In the temporal and in the frontal cortex, a late (beginning at 2 h) and prolonged (up to 24 h) decrease in both prodynorphin mRNA and ir-dynorphin A levels have been observed.
Negative_regulation (decrease) of prodynorphin in frontal cortex associated with dynorphin and urological neuroanatomy
12) Confidence 0.58 Published 1999 Journal J. Mol. Neurosci. Section Abstract Doc Link 10691294 Disease Relevance 0.71 Pain Relevance 0.46
During gestational day 22, the content of dynorphin precursor is reduced significantly (approximately 50%).
Negative_regulation (reduced) of dynorphin precursor associated with dynorphin
13) Confidence 0.57 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643115 Disease Relevance 0 Pain Relevance 1.14
Thus, recurrent limbic seizures activate both prodynorphin and proenkephalin genes, whereas generalized clonic-tonic seizures seem to decrease the prodynorphin and increase the proenkephalin gene expression in the dentate gyrus.
Negative_regulation (decrease) of prodynorphin in dentate gyrus associated with convulsion
14) Confidence 0.57 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477937 Disease Relevance 0.34 Pain Relevance 0.11
However, the levels of prodynorphin mRNA were significantly reduced in the medial nucleus accumbens and caudomedial striatum.
Negative_regulation (reduced) of prodynorphin in medial associated with nucleus accumbens
15) Confidence 0.57 Published 1988 Journal Brain Res. Section Abstract Doc Link 3179742 Disease Relevance 0 Pain Relevance 0.44
Striatal proenkephalin and prodynorphin messenger RNA levels were increased and decreased, respectively, after complete 6-hydroxydopamine lesion.
Negative_regulation (decreased) of prodynorphin
16) Confidence 0.57 Published 1993 Journal Neuroscience Section Abstract Doc Link 8232904 Disease Relevance 0 Pain Relevance 0.76
A glutamate antagonist blocks perforant path stimulation-induced reduction of dynorphin peptide and prodynorphin mRNA levels in rat hippocampus.
Negative_regulation (reduction) of prodynorphin in hippocampus associated with glutamate, dynorphin, antagonist, enkephalin and hippocampus
17) Confidence 0.57 Published 1991 Journal Brain Res. Section Title Doc Link 1685342 Disease Relevance 0 Pain Relevance 0.57
Pretreatment of rats with DM decreased hippocampal PENK and PDYN mRNA levels and seizure activity induced by KA.
Negative_regulation (decreased) of PDYN mRNA associated with convulsion and dextromethorphan
18) Confidence 0.56 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179861 Disease Relevance 0.43 Pain Relevance 0.79
The budesonide-induced reduction of prodynorphin mRNA levels was more pronounced in the deep dorsal horn than in the superficial dorsal horn.
Negative_regulation (reduction) of prodynorphin mRNA in dorsal horn associated with dorsal horn
19) Confidence 0.55 Published 1994 Journal Neuroscience Section Abstract Doc Link 7898656 Disease Relevance 0.74 Pain Relevance 0.60
In contrast, the PDYN mRNA level was found to be decreased in the anterior lobe during the withdrawal (by about 43%).
Negative_regulation (decreased) of PDYN mRNA in anterior lobe associated with withdrawal
20) Confidence 0.54 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 7969792 Disease Relevance 0 Pain Relevance 0.25

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