INT55980

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Context Info
Confidence 0.16
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.64
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PROC) extracellular space (PROC) extracellular region (PROC)
plasma membrane (PROC)
PROC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 128 99.52 Very High Very High Very High
lidocaine 8 96.84 Very High Very High Very High
COX2 4 93.08 High High
cINOD 18 63.96 Quite High
Parenteral administration 2 63.56 Quite High
Inflammatory response 10 61.36 Quite High
Bile 14 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
diclofenac 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 132 99.52 Very High Very High Very High
Colon Cancer 12 89.60 High High
Cancer 2 85.00 Quite High
Pressure Volume 2 Under Development 2 84.64 Quite High
Inflammatory Bowel Disease 94 70.16 Quite High
Disease 32 69.20 Quite High
Polyps 2 61.44 Quite High
Intestinal Polyps 2 60.28 Quite High
Familial Adenomatous Polyposis 2 57.92 Quite High
Toxicity 2 41.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results seem to exclude the possibility of enhanced PC breakdown and further suggest that the main inhibitory effect is on the CDP-choline pathway for PC biosynthesis.
Spec (possibility) Positive_regulation (enhanced) of Protein_catabolism (breakdown) of PC
1) Confidence 0.16 Published 1994 Journal Cell Biochem. Funct. Section Abstract Doc Link 8044894 Disease Relevance 0 Pain Relevance 0.45
Although the increased degradation of PC by cPLA2?
Positive_regulation (increased) of Protein_catabolism (degradation) of PC
2) Confidence 0.03 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.75 Pain Relevance 0.21
in the regulation of various pathological conditions, its effect resulting from the degradation of membrane PC.
Positive_regulation (resulting) of Protein_catabolism (degradation) of PC
3) Confidence 0.02 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.89 Pain Relevance 0.38

General Comments

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