INT55982

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Context Info
Confidence 0.55
First Reported 1994
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.02
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
Plasma 2
fat 2
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 13 100.00 Very High Very High Very High
noradrenaline 4 100.00 Very High Very High Very High
antagonist 14 99.52 Very High Very High Very High
Clonidine 3 98.30 Very High Very High Very High
Glutamate 1 96.68 Very High Very High Very High
agonist 9 94.48 High High
Calcium channel 9 91.44 High High
tolerance 2 84.64 Quite High
Neuropeptide 3 69.64 Quite High
Action potential 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Growth Problems 1 98.36 Very High Very High Very High
Targeted Disruption 6 98.16 Very High Very High Very High
Impaired Glucose Tolerance 4 84.64 Quite High
Diabetes Mellitus 3 81.04 Quite High
Congenital Anomalies 1 79.64 Quite High
Growth Hormone Deficiency 1 75.00 Quite High
Intrauterine Growth Retardation 1 71.76 Quite High
Cancer 3 50.72 Quite High
Obesity 2 31.12 Quite Low
Coronary Artery Disease 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concomitant treatment of animals with the beta-adrenergic antagonist propranolol completely blocked the noradrenaline-induced suppression of GH.
Negative_regulation (blocked) of Negative_regulation (suppression) of GH associated with antagonist and noradrenaline
1) Confidence 0.55 Published 1994 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 8045100 Disease Relevance 0 Pain Relevance 0.36
Plasma growth hormone (GH) levels at the end of insulin and clonidine tests were considered for classification of children into 3 categories according to severity of GH deficit: total deficit of GH (TD), partial deficit (PD, and familiar short stature (FSS; no deficit of GH).
Spec (partial) Negative_regulation (severity) of Spec (partial) Negative_regulation (deficit) of GH in Plasma associated with growth problems and clonidine
2) Confidence 0.40 Published 2002 Journal Metab. Clin. Exp. Section Abstract Doc Link 11782864 Disease Relevance 0.63 Pain Relevance 0.12
High-dose ghrelin reduced the loss of whole body fat (P < .04) and serum GH (P < .05).
Negative_regulation (reduced) of Negative_regulation (loss) of GH in fat
3) Confidence 0.24 Published 2010 Journal Cancer Section Body Doc Link 20186829 Disease Relevance 0.05 Pain Relevance 0
Several biochemical approaches have been studied to define GH deficiency in the adult and no universal consensus has yet been reached.
Negative_regulation (define) of Negative_regulation (deficiency) of GH
4) Confidence 0.23 Published 1996 Journal Horm. Res. Section Abstract Doc Link 8950617 Disease Relevance 0.15 Pain Relevance 0.12
In addition, this hypothalamic effect of ghrelin is independent of somatostatin, the inhibitor of the GH axis, since it is also found in somatostatin knockout mice.
Neg (independent) Negative_regulation (independent) of Negative_regulation (inhibitor) of GH associated with targeted disruption and somatostatin
5) Confidence 0.20 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2820089 Disease Relevance 0.18 Pain Relevance 0.28

General Comments

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