INT55986

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Context Info
Confidence 0.48
First Reported 1994
Last Reported 2001
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.76
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
locus coeruleus 6
pontine nucleus 2
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 9 98.76 Very High Very High Very High
Endogenous opioid 9 94.20 High High
Locus ceruleus 4 50.00 Quite Low
opiate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 16 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: This review focuses on corticotropin-releasing factor (CRF), a critical substrate of the stress response, and its potential for interactions with endogenous opioid systems within the pontine nucleus, locus coeruleus (LC), a brain region that has been implicated as a target in response to stress and opiates.
Positive_regulation (focuses) of corticotropin-releasing factor Binding (interactions) of in locus coeruleus
1) Confidence 0.48 Published 2001 Journal Psychopharmacology (Berl.) Section Body Doc Link 11797054 Disease Relevance 0.19 Pain Relevance 0
OBJECTIVE: This review focuses on corticotropin-releasing factor (CRF), a critical substrate of the stress response, and its potential for interactions with endogenous opioid systems within the pontine nucleus, locus coeruleus (LC), a brain region that has been implicated as a target in response to stress and opiates.
Positive_regulation (focuses) of CRF Binding (interactions) of in locus coeruleus
2) Confidence 0.48 Published 2001 Journal Psychopharmacology (Berl.) Section Body Doc Link 11797054 Disease Relevance 0.19 Pain Relevance 0
OBJECTIVE: This review focuses on corticotropin-releasing factor (CRF), a critical substrate of the stress response, and its potential for interactions with endogenous opioid systems within the pontine nucleus, locus coeruleus (LC), a brain region that has been implicated as a target in response to stress and opiates.
Positive_regulation (focuses) of corticotropin-releasing factor in pontine nucleus Binding (interactions) of in locus coeruleus
3) Confidence 0.16 Published 2001 Journal Psychopharmacology (Berl.) Section Body Doc Link 11797054 Disease Relevance 0.19 Pain Relevance 0
OBJECTIVE: This review focuses on corticotropin-releasing factor (CRF), a critical substrate of the stress response, and its potential for interactions with endogenous opioid systems within the pontine nucleus, locus coeruleus (LC), a brain region that has been implicated as a target in response to stress and opiates.
Positive_regulation (focuses) of CRF in pontine nucleus Binding (interactions) of in locus coeruleus
4) Confidence 0.16 Published 2001 Journal Psychopharmacology (Berl.) Section Body Doc Link 11797054 Disease Relevance 0.19 Pain Relevance 0
To evaluate the possible interaction of CRH and alpha MSH, eight women in the luteal phase underwent the following tests: 1) ovine CRH infused at 100 micrograms/h for 3 h, 2) alpha MSH (2.5 mg as an iv bolus 60 min after the start of saline infusion), 3) CRH plus alpha MSH (injected 60 min after the start of CRH infusion), and 4) placebo.
Spec (possible) Positive_regulation (evaluate) of CRH Binding (interaction) of
5) Confidence 0.06 Published 1994 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8045978 Disease Relevance 0 Pain Relevance 0.19

General Comments

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