INT5599

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Context Info
Confidence 0.52
First Reported 1991
Last Reported 2010
Negated 6
Speculated 5
Reported most in Abstract
Documents 25
Total Number 29
Disease Relevance 3.07
Pain Relevance 13.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) plasma membrane (Drd2) signal transducer activity (Drd2)
Anatomy Link Frequency
striatum 6
brain 3
neurons 2
dorsal 1
bladder 1
Drd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 147 100.00 Very High Very High Very High
dopamine receptor 46 100.00 Very High Very High Very High
Morphine 32 100.00 Very High Very High Very High
Enkephalin 25 100.00 Very High Very High Very High
agonist 23 100.00 Very High Very High Very High
nMDA receptor 22 100.00 Very High Very High Very High
antagonist 18 100.00 Very High Very High Very High
Glutamate 14 100.00 Very High Very High Very High
narcan 10 100.00 Very High Very High Very High
MU agonist 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 90 99.84 Very High Very High Very High
Disease 7 98.24 Very High Very High Very High
Dystonia 1 93.88 High High
Cognitive Disorder 11 93.56 High High
Opiate Addiction 10 92.76 High High
Depression 4 91.92 High High
Neuroblastoma 2 88.88 High High
Sleep Disorders 1 86.80 High High
Stress 14 85.84 High High
Schizophrenia 3 84.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of neonatal 6-hydroxydopamine injections on glutamate decarboxylase, preproenkephalin and dopamine D2 receptor mRNAs in the adult rat striatum.
Regulation (Effects) of dopamine D2 receptor in striatum associated with dopamine, glutamate and enkephalin
1) Confidence 0.52 Published 1993 Journal Brain Res. Section Title Doc Link 7902185 Disease Relevance 0 Pain Relevance 0.49
The effects of the selective dopamine D2 receptor antagonists YM-09151-2 and l-sulpiride on the in vivo release of dopamine (DA), L-3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) in rat striatum were investigated.
Spec (investigated) Regulation (effects) of dopamine D2 receptor in striatum associated with dopamine and antagonist
2) Confidence 0.45 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8473891 Disease Relevance 0 Pain Relevance 0.37
In addition, both fumes caused persistent down-regulation of dopamine D2 receptor (Drd2; 30-40%) and vesicular monoamine transporter 2 (Vmat2; 30-55%) mRNAs in the midbrain.
Regulation (regulation) of dopamine D2 receptor in midbrain associated with dopamine, midbrain and monoamine
3) Confidence 0.44 Published 2010 Journal Arch. Toxicol. Section Abstract Doc Link 20224926 Disease Relevance 0.47 Pain Relevance 0.34
Quantitative in situ hybridization evidence for differential regulation of proenkephalin and dopamine D2 receptor mRNA levels in the rat striatum: effects of unilateral intrastriatal injections of 6-hydroxydopamine.
Regulation (regulation) of D2 receptor mRNA in striatum associated with dopamine and enkephalin
4) Confidence 0.39 Published 1992 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 1312206 Disease Relevance 0 Pain Relevance 0.15
Furthermore, we studied the contribution of the dopamine D2 and serotonin 5-HT2A antagonist components of risperidone in establishing its effects on neuropeptide mRNA levels in the striatum.
Regulation (contribution) of dopamine D2 in striatum associated with dopamine, antagonist, neuropeptide and serotonin
5) Confidence 0.37 Published 1998 Journal Synapse Section Abstract Doc Link 9517839 Disease Relevance 0 Pain Relevance 0.31
CONCLUSION: On the basis of an analysis spanning the whole gene locus, from the DRD2 promoter to the ANKK1 rs1800497C>T polymorphism, DRD2 genetic polymorphisms modulate both the risk of opiate addiction, leading to the necessity of methadone substitution therapy, and the course of this therapy in terms of dosage requirements.


Regulation (modulate) of DRD2
6) Confidence 0.37 Published 2009 Journal Pharmacogenet. Genomics Section Body Doc Link 19373123 Disease Relevance 0 Pain Relevance 0
D2 dopamine receptor agonists can reverse the effect of NMDA receptor blockade on bladder activity but were ineffective in reversing the block of sphincter activity.
Regulation (ineffective) of D2 dopamine receptor in bladder associated with nmda receptor, dopamine receptor and agonist
7) Confidence 0.36 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11312567 Disease Relevance 0.48 Pain Relevance 0.38
The purpose of our study was to examine the effects of D1-and D2-dopamine receptors blockade on the changes in the ventricular content of catecholamines in rats withdrawn from morphine.
Spec (examine) Regulation (effects) of D2-dopamine associated with catecholamine, dopamine receptor and morphine
8) Confidence 0.35 Published 2001 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 11697748 Disease Relevance 0 Pain Relevance 0.93
Chronic treatment of rats with the specific sigma ligand D-pentazocine fails to modulate dopamine D2 and sigma binding in brain.
Neg (fails) Regulation (modulate) of dopamine D2 in brain associated with fortral and dopamine
9) Confidence 0.28 Published 1991 Journal Eur. J. Pharmacol. Section Title Doc Link 1648492 Disease Relevance 0 Pain Relevance 0.57
The effects of bilateral olfactory bulbectomy (OBX) on prepro-enkephalin, thyrotropin-releasing hormone, and D-2 receptor mRNA levels in the ventral striatum were examined by in situ hybridization histochemistry.
Spec (examined) Regulation (effects) of D-2 receptor mRNA in ventral associated with enkephalin
10) Confidence 0.28 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657493 Disease Relevance 0 Pain Relevance 0.43
Changes in striatal dopamine uptake sites, D2 receptor and preproenkephalin (PPE) mRNA levels provoked by unilateral 6-hydroxydopamine-induced lesion of the nigrostriatal dopaminergic (DA) pathway were studied by quantitative autoradiography and in situ hybridization (ISH) in rats sacrificed at different post-lesion delays.
Regulation (Changes) of D2 receptor associated with dopamine
11) Confidence 0.27 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8231735 Disease Relevance 0 Pain Relevance 0.09
The aim of this study was to investigate the effect of extremely low-frequency electromagnetic field (ELF-EMF) exposure during morphine treatment on dopamine D2 receptor (D2R) density in the rat dorsal hippocampus following withdrawal.
Spec (investigate) Regulation (effect) of dopamine D2 receptor in hippocampus associated with dopamine, hippocampus, withdrawal and morphine
12) Confidence 0.26 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18276072 Disease Relevance 0 Pain Relevance 0.91
Microiontophoretic studies of the effects of D-1 and D-2 receptor agonists on type I caudate nucleus neurons: lack of synergistic interaction.
Regulation (effects) of D-2 receptor in neurons associated with anesthesia and agonist
13) Confidence 0.26 Published 1992 Journal Synapse Section Title Doc Link 1354398 Disease Relevance 0.07 Pain Relevance 0.37
These results demonstrate that haloperidol treatment acts at the gene level to modulate D2 receptor content in striatal dopaminoceptive neurons, and that the D2 receptor mRNA increase in postsynaptic neurons contributes to dopamine supersensitivity induced by neuroleptics in the rat.
Regulation (modulate) of D2 receptor in neurons associated with dopamine
14) Confidence 0.25 Published 1991 Journal Neuroscience Section Abstract Doc Link 1754061 Disease Relevance 0 Pain Relevance 0.15
The D2 dopamine receptor antagonist, sulpiride, did not change the mRNA levels of either GAD67 or PPE in the striatum.
Neg (not) Regulation (change) of D2 dopamine receptor in striatum associated with antagonist and dopamine receptor
15) Confidence 0.22 Published 1994 Journal Brain Res. Section Abstract Doc Link 8004444 Disease Relevance 0.07 Pain Relevance 0.40
In contrast, acute treatment with FNM for 3 h had no significant effects on D1 or D2 dopamine receptor mRNAs in striatum.
Neg (no) Regulation (effects) of D2 dopamine receptor in striatum associated with dopamine receptor
16) Confidence 0.21 Published 1994 Journal Neurochem. Int. Section Abstract Doc Link 7820070 Disease Relevance 0 Pain Relevance 0.87
In conclusion, the DRD2 genotype effects did not affect opioid maintenance treatment outcomes.
Neg (not) Regulation (affect) of DRD2 associated with opioid
17) Confidence 0.21 Published 2006 Journal Am. J. Med. Genet. B Neuropsychiatr. Genet. Section Abstract Doc Link 16583408 Disease Relevance 0.27 Pain Relevance 1.30
Quantitative densitometry was used to measure changes in mRNA levels for preproenkephalin A (ENK), D1 dopamine receptor, protachykinin (SubP), glutamic acid decarboxylase (GAD65), and D2 dopamine receptor.
Regulation (changes) of D2 dopamine receptor associated with dopamine receptor
18) Confidence 0.19 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630515 Disease Relevance 0 Pain Relevance 0.34
Time-course of changes in striatal levels of DA uptake sites, DA D2 receptor and preproenkephalin mRNAs after nigrostriatal dopaminergic denervation in the rat.
Regulation (changes) of D2 receptor associated with enkephalin
19) Confidence 0.17 Published 1993 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8231735 Disease Relevance 0 Pain Relevance 0.19
These compounds exhibited little or no affinity for dopamine-D2, kappa opiate or phencyclidine receptors and displayed high biological efficacy in assays of sigma receptor function, ability to produce alterations in motor behavior and inhibition of the muscarinic cholinergic phosphoinositide response.
Neg (little) Regulation (affinity) of dopamine-D2 associated with dopamine and opiate
20) Confidence 0.17 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1320690 Disease Relevance 0 Pain Relevance 0.19

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