INT56012

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Context Info
Confidence 0.05
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.67
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

PTDSS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ketamine 12 96.94 Very High Very High Very High
palliative 1 90.28 High High
Bile 2 65.84 Quite High
anesthesia 1 42.32 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 3 100.00 Very High Very High Very High
Obstructive Jaundice 1 92.04 High High
Malignant Neoplastic Disease 1 91.20 High High
Infection 1 87.44 High High
Hepatocellular Cancer 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adsorption of fibronectin to rubber--representing material used for biliary drainage--and subsequent adherence of Escherichia coli strain PSS1 and E. coli strain NG7C (which binds to immobilised fibronectin) were investigated.
Negative_regulation (adherence) of PSS1 associated with sprains and strains
1) Confidence 0.05 Published 1994 Journal J. Med. Microbiol. Section Abstract Doc Link 8046737 Disease Relevance 0.55 Pain Relevance 0.12
Therefore, this study shows that therapeutic concentrations of ketamine can disrupt F-actin and microtubular cytoskeletons possibly through suppression of intracellular calcium mobilization and cellular ATP synthesis due to down-regulation of the mitochondrial membrane potential and complex I enzyme activity.
Negative_regulation (down-regulation) of complex I enzyme associated with ketamine
2) Confidence 0.03 Published 2009 Journal Drug Metab. Dispos. Section Abstract Doc Link 18845661 Disease Relevance 0.13 Pain Relevance 0.38

General Comments

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