INT56014

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Context Info
Confidence 0.52
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.22
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pzp) extracellular region (Pzp)
Anatomy Link Frequency
radial 1
Pzp (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 3 100.00 Very High Very High Very High
antinociception 15 99.96 Very High Very High Very High
opioid receptor 6 99.08 Very High Very High Very High
narcan 3 92.88 High High
tail-flick 6 86.36 High High
agonist 6 76.28 Quite High
antagonist 3 74.72 Quite High
cerebral cortex 15 48.88 Quite Low
Pain 3 25.00 Low Low
Somatosensory cortex 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 3 94.40 High High
Neurodegenerative Disease 18 67.44 Quite High
Disseminated Intravascular Coagulation 30 53.36 Quite High
Malformations Of Cortical Development 21 30.56 Quite Low
Epilepsy 3 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low
Schizophrenia 3 5.00 Very Low Very Low Very Low
Intellectual Impairment 3 5.00 Very Low Very Low Very Low
Autism 3 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that heroin activated supraspinal delta 1 receptors and MAM acted on supraspinal delta 2 receptors to produce antinociception in Swiss Webster mice.
Gene_expression (produce) of MAM associated with antinociception
1) Confidence 0.52 Published 1994 Journal Life Sci. Section Abstract Doc Link 8046996 Disease Relevance 0 Pain Relevance 0.65
Previous work from this laboratory established that heroin and MAM, given intracerebroventricularly (i.c.v.) in Swiss Webster mice, produce antinociception through activation of supraspinal delta receptors.
Gene_expression (produce) of MAM associated with antinociception
2) Confidence 0.41 Published 1994 Journal Life Sci. Section Abstract Doc Link 8046996 Disease Relevance 0 Pain Relevance 0.55
The purpose of this study was to determine which delta (delta) opioid receptor subtype, delta 1 or delta 2, was involved in producing the antinociceptive action of heroin and 6-monacetylmorphine (MAM) in Swiss Webster mice.
Gene_expression (producing) of MAM associated with opioid receptor and antinociceptive
3) Confidence 0.41 Published 1994 Journal Life Sci. Section Abstract Doc Link 8046996 Disease Relevance 0 Pain Relevance 0.41
In MAM treated animals at a similar age, these markers are not expressed homogeneously and about half of radial glia express vimentin but do not express detectable levels of BLBP.
Neg (not) Gene_expression (expressed) of MAM in radial
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.16 Pain Relevance 0
To assess the effect of a diffuse source of reelin, MAM treated slices were incubated in medium containing recombinant reelin (1 nM) or plain medium as a control.
Gene_expression (source) of MAM
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
To create a focal and normotopic source of reelin, MAM slices were co-cultured with reelin-secreting HEK cells included in Matrigel and placed at the pial surface [39] (Figure 4a–c).
Gene_expression (source) of MAM
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.05 Pain Relevance 0

General Comments

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