INT56016

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Context Info
Confidence 0.47
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.11
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pzp) extracellular region (Pzp)
Anatomy Link Frequency
plasma 2
secondary somatosensory cortex 1
Pzp (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 3 100.00 Very High Very High Very High
cytokine 15 99.96 Very High Very High Very High
Inflammation 12 99.90 Very High Very High Very High
Peripheral nerve injury 9 98.92 Very High Very High Very High
antinociception 10 97.96 Very High Very High Very High
Somatosensory cortex 1 97.68 Very High Very High Very High
ketamine 1 96.32 Very High Very High Very High
anesthesia 1 95.60 Very High Very High Very High
tail-flick 4 92.52 High High
agonist 4 82.44 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 15 100.00 Very High Very High Very High
Neuropathic Pain 3 100.00 Very High Very High Very High
INFLAMMATION 12 99.90 Very High Very High Very High
Cancer 3 95.84 Very High Very High Very High
Necrosis 3 95.60 Very High Very High Very High
Toxicity 3 91.96 High High
Alzheimer's Dementia 2 89.76 High High
Death 3 68.08 Quite High
Injury 9 59.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the ED50 value of MAM was increased 3-fold by NTB and was not altered by BNTX administration.
Positive_regulation (increased) of MAM
1) Confidence 0.47 Published 1994 Journal Life Sci. Section Abstract Doc Link 8046996 Disease Relevance 0 Pain Relevance 0.73
These results suggest that heroin activated supraspinal delta 1 receptors and MAM acted on supraspinal delta 2 receptors to produce antinociception in Swiss Webster mice.
Positive_regulation (activated) of MAM associated with antinociception
2) Confidence 0.16 Published 1994 Journal Life Sci. Section Abstract Doc Link 8046996 Disease Relevance 0 Pain Relevance 0.68
Previously, we generated an alpha2M derivative (alpha(2)-macroglobulin activated for cytokine binding; MAC) similar in structure to alpha(2)M conformational intermediates, which binds tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and inhibits endotoxin toxicity.
Positive_regulation (activated) of macroglobulin associated with toxicity, necrosis, cancer and cytokine
3) Confidence 0.11 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17725582 Disease Relevance 1.05 Pain Relevance 0.53
Although inflammation is coupled to axonal regeneration, fulminant inflammation may increase nerve damage and neuropathic pain. alpha(2)-Macroglobulin (alpha2M) is a plasma protease inhibitor, cytokine carrier, and ligand for cell-signaling receptors, which exists in two well-characterized conformations and in less well-characterized intermediate states.
Spec (may) Positive_regulation (increase) of Macroglobulin in plasma associated with nervous system injury, inflammation, neuropathic pain and cytokine
4) Confidence 0.08 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17725582 Disease Relevance 0.86 Pain Relevance 0.49
A derivative of the plasma protease inhibitor alpha(2)-macroglobulin regulates the response to peripheral nerve injury.
Positive_regulation (derivative) of macroglobulin in plasma associated with nervous system injury, cytokine and peripheral nerve injury
5) Confidence 0.07 Published 2007 Journal J. Neurochem. Section Title Doc Link 17725582 Disease Relevance 1.03 Pain Relevance 0.59
After microinjection of [(125)I]activated alpha2-macroglobulin (alpha 2M), a typical LRP-1 ligand, into mouse secondary somatosensory cortex region under ketamine-xylazine anesthesia, residual radioactivity was not significantly decreased up to 90 min, whereas after microinjection of [(125)I]human A beta(1-40) [hA beta(1-40)], the residual radioactivity decreased time-dependently.
Positive_regulation (activated) of alpha2-macroglobulin in secondary somatosensory cortex associated with somatosensory cortex, anesthesia and ketamine
6) Confidence 0.04 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20367755 Disease Relevance 0.16 Pain Relevance 0.19

General Comments

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