INT56017

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Context Info
Confidence 0.44
First Reported 1994
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.24
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pzp) extracellular region (Pzp)
Pzp (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 8 100.00 Very High Very High Very High
Morphine 9 97.64 Very High Very High Very High
antinociception 12 95.92 Very High Very High Very High
narcan 5 95.36 Very High Very High Very High
tail-flick 4 92.88 High High
agonist 5 82.80 Quite High
Enkephalin 2 80.32 Quite High
Spinal cord 2 80.20 Quite High
antagonist 3 76.36 Quite High
Delta opioid receptors 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 3 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The unique receptor actions and changes produced by streptozotocin suggest that extrinsic in addition to genetic factors influence the opioid receptor selectivity of heroin and 6 MAM.
Regulation (influence) of MAM associated with opioid receptor
1) Confidence 0.44 Published 1998 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 9920201 Disease Relevance 0.24 Pain Relevance 0.85
Also, this MAM response was inhibited by i.t. administration of methysergide which is consistent with supraspinal mu receptor activation.
Regulation (response) of MAM
2) Confidence 0.23 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8138935 Disease Relevance 0 Pain Relevance 0.97
On the other hand, the ED50 value of MAM was increased 3-fold by NTB and was not altered by BNTX administration.
Regulation (value) of MAM
3) Confidence 0.18 Published 1994 Journal Life Sci. Section Abstract Doc Link 8046996 Disease Relevance 0 Pain Relevance 0.73

General Comments

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