INT56027

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 4.96
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ncam1) aging (Ncam1) cell adhesion (Ncam1)
plasma membrane (Ncam1)
Anatomy Link Frequency
dentate gyrus 2
neurons 2
telencephalon 1
brain 1
neural 1
Ncam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 3 100.00 Very High Very High Very High
antidepressant 4 99.78 Very High Very High Very High
Pain 7 99.74 Very High Very High Very High
long-term potentiation 15 99.52 Very High Very High Very High
fluoxetine 7 99.38 Very High Very High Very High
antagonist 1 96.44 Very High Very High Very High
Analgesic 8 95.84 Very High Very High Very High
Neuropathic pain 3 92.80 High High
gABA 2 91.20 High High
Hippocampus 3 87.40 High High
Disease Link Frequency Relevance Heat
Adhesions 21 100.00 Very High Very High Very High
Stress 8 100.00 Very High Very High Very High
Alzheimer's Dementia 6 100.00 Very High Very High Very High
Pain 8 99.74 Very High Very High Very High
Body Weight 3 93.96 High High
Neuropathic Pain 3 92.80 High High
Convulsion 4 88.76 High High
Injury 26 88.24 High High
Nociception 1 86.52 High High
Depression 5 83.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, PSA-NCAM surface translocation was inhibited reversibly by cooling the cultures at 20 degrees C, a procedure which blocks constitutive secretion and which resulted in accumulation of PSA-NCAM in the cytoplasm of oxytocinergic and non-oxytocinergic neurons.
Positive_regulation (accumulation) of NCAM in neurons
1) Confidence 0.69 Published 2001 Journal Neuroscience Section Abstract Doc Link 11311794 Disease Relevance 0.07 Pain Relevance 0.17
The extracellular concentrations of the amyloid precursor protein (APP) and neural-cell adhesion molecule (NCAM) in the dentate gyrus of the anaesthetized rat were assayed before and after the induction of long-term potentiation (LTP) in vivo.
Positive_regulation (concentrations) of NCAM in dentate gyrus associated with alzheimer's dementia, long-term potentiation and adhesions
2) Confidence 0.46 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8047297 Disease Relevance 0.28 Pain Relevance 0.17
Glial cell line-derived neurotrophic factor (GDNF) has a variety of functions affecting the survival and development of specified neural cell populations, mediated via transmission of intracellular signals through binding to its high-affinity receptor, GFR*1, and subsequent activation of a tyrosine receptor kinase, RET, neural cell adhesion molecule (NCAM), or other signaling molecules.
Positive_regulation (activation) of NCAM in neural associated with adhesions
3) Confidence 0.46 Published 2008 Journal Pain Section Abstract Doc Link 17967506 Disease Relevance 0.85 Pain Relevance 0.94
There were no significant changes in behavioral pain thresholds, circulating corticosterone concentrations (after acute immobilization stress) or NCAM and synaptophysin levels in various brain regions by the diet treatments.
Positive_regulation (circulating) of NCAM in brain associated with stress and pain
4) Confidence 0.44 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12727319 Disease Relevance 1.15 Pain Relevance 0.36
This reaction disappeared after exposure of the cultures to endoneuraminidase, an enzyme which specifically cleaves alpha-2-8-linked PSA from NCAM.
Positive_regulation (cleaves) of NCAM
5) Confidence 0.44 Published 2001 Journal Neuroscience Section Abstract Doc Link 11311794 Disease Relevance 0.19 Pain Relevance 0.16
In general, chronic fluoxetine treatment induces significant increases in the number of PSA-NCAM immunoreactive neurons and in neuropil immunostaining and coadministration of the 5-HT3 antagonist ondansetron blocks the effects of fluoxetine on PSA-NCAM expression.
Positive_regulation (increases) of PSA-NCAM in neuropil associated with antagonist and fluoxetine
6) Confidence 0.40 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16900104 Disease Relevance 0.27 Pain Relevance 0.78
This activation is especially pronounced in the piriform cortex and may be caused by a particularly marked synaptic vulnerability and remodeling in this area, as demonstrated by the increased NCAM/D3-ratio.
Positive_regulation (increased) of NCAM in piriform cortex
7) Confidence 0.39 Published 1993 Journal Biol. Psychiatry Section Abstract Doc Link 8373917 Disease Relevance 0.65 Pain Relevance 0.43
Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized rats.
Positive_regulation (Increase) of NCAM in dentate gyrus associated with anesthesia, alzheimer's dementia and long-term potentiation
8) Confidence 0.37 Published 1994 Journal Neurosci. Lett. Section Title Doc Link 8047297 Disease Relevance 0.28 Pain Relevance 0.31
Ninety minutes after the induction of LTP, the concentrations of NCAM and APP increased, in an NMDA-dependent manner, in the absence of changes in neurofilament and arylsulphatase levels.
Positive_regulation (increased) of NCAM associated with long-term potentiation
9) Confidence 0.37 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8047297 Disease Relevance 0.24 Pain Relevance 0.22
Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon.
Positive_regulation (induces) of PSA-NCAM in telencephalon associated with antidepressant
10) Confidence 0.21 Published 2007 Journal Eur Neuropsychopharmacol Section Title Doc Link 17307340 Disease Relevance 0.15 Pain Relevance 0.44
Non-myelinating Schwann cells (NCAM stained) in the distal nerve segment increased when repair was delayed, indicating abundant regeneration of non-myelinated axons after delayed nerve repair.
Positive_regulation (increased) of NCAM in nerve
11) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2556676 Disease Relevance 0.76 Pain Relevance 0.06
Clinical and histopathological data were reviewed and immunohistochemical analysis was performed for S100, CD56, neuron-specific enolase, epithelial membrane antigen, CK7, CK8, CK14, and CK20.
Positive_regulation (performed) of CD56 in neuron
12) Confidence 0.04 Published 2009 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 19913727 Disease Relevance 0.07 Pain Relevance 0.07

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