INT56028

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.38
First Reported 1993
Last Reported 2006
Negated 3
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.60
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ncam1) aging (Ncam1) cell adhesion (Ncam1)
plasma membrane (Ncam1)
Anatomy Link Frequency
brain 1
piriform cortex 1
amygdala 1
neural 1
Ncam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 10 100.00 Very High Very High Very High
Pain 4 100.00 Very High Very High Very High
long-term potentiation 5 99.88 Very High Very High Very High
amygdala 6 98.14 Very High Very High Very High
Hippocampus 3 90.76 High High
lidocaine 10 87.92 High High
analgesia 1 50.00 Quite Low
Root ganglion neuron 1 50.00 Quite Low
anesthesia 2 25.00 Low Low
narcan 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Adhesions 23 100.00 Very High Very High Very High
Stress 8 100.00 Very High Very High Very High
Pain 4 100.00 Very High Very High Very High
Shock 14 98.22 Very High Very High Very High
Body Weight 8 95.52 Very High Very High Very High
Convulsion 8 85.12 High High
Alzheimer's Dementia 2 83.20 Quite High
Disease 4 72.24 Quite High
Ganglion Cysts 1 50.00 Quite Low
Pulmonary Hypertension 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: The effects of the anti-neural-cell-adhesion molecule (anti-NCAM) were assessed on cold water swim stress-induced antinociception in Wistar rats with Freund's adjuvant-induced inflammation of one hindpaw.
Regulation (effects) of anti-NCAM in neural
1) Confidence 0.38 Published 2006 Journal Anesth. Analg. Section Body Doc Link 17122239 Disease Relevance 0 Pain Relevance 0
There were no significant changes in behavioral pain thresholds, circulating corticosterone concentrations (after acute immobilization stress) or NCAM and synaptophysin levels in various brain regions by the diet treatments.
Neg (no) Regulation (changes) of NCAM in brain associated with stress and pain
2) Confidence 0.24 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12727319 Disease Relevance 1.15 Pain Relevance 0.36
In both piriform cortex and amygdala ECS also induced a significant decrease in D3-protein (a marker of mature synapses), but no change in NCAM (especially enriched in newly formed synapses).
Neg (no) Regulation (change) of NCAM in amygdala associated with shock and amygdala
3) Confidence 0.22 Published 1993 Journal Biol. Psychiatry Section Abstract Doc Link 8373917 Disease Relevance 0.96 Pain Relevance 0.57
Ninety minutes after the induction of LTP, the concentrations of NCAM and APP increased, in an NMDA-dependent manner, in the absence of changes in neurofilament and arylsulphatase levels.
Regulation (concentrations) of NCAM associated with long-term potentiation
4) Confidence 0.22 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8047297 Disease Relevance 0.24 Pain Relevance 0.22
In both piriform cortex and amygdala ECS also induced a significant decrease in D3-protein (a marker of mature synapses), but no change in NCAM (especially enriched in newly formed synapses).
Neg (no) Regulation (change) of NCAM in piriform cortex associated with shock and amygdala
5) Confidence 0.08 Published 1993 Journal Biol. Psychiatry Section Abstract Doc Link 8373917 Disease Relevance 0.96 Pain Relevance 0.57
The up-regulated genes include 7 MMPs (MMP 2, MMP 8, MMP 9, MMP 10, MMP 11, MMP 12, MMP 20), 1 serine protease (Plat), 3 cell adhesion molecules (ICAM-1, NCAM-1, Itgax), and 1 protease inhibitor (Serpinb2).
Regulation (regulated) of NCAM-1 associated with metalloproteinase and adhesions
6) Confidence 0.05 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.28 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox