INT56029

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Context Info
Confidence 0.52
First Reported 1993
Last Reported 2008
Negated 1
Speculated 4
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 2.83
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nefm) cytoskeleton (Nefm)
Anatomy Link Frequency
plasma 1
spinal cord 1
perikaryons 1
bladder 1
internal 1
Nefm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 5 100.00 Very High Very High Very High
Central nervous system 2 99.96 Very High Very High Very High
long-term potentiation 5 99.56 Very High Very High Very High
cerebral cortex 3 99.48 Very High Very High Very High
induced neuropathy 10 98.72 Very High Very High Very High
Spinal cord 10 97.08 Very High Very High Very High
Sciatic nerve 10 96.24 Very High Very High Very High
Locus ceruleus 3 93.64 High High
Raphe 3 92.40 High High
Peripheral nervous system 2 89.44 High High
Disease Link Frequency Relevance Heat
Hypertrophy 1 99.56 Very High Very High Very High
Neuropathic Pain 11 98.72 Very High Very High Very High
Frailty 9 97.68 Very High Very High Very High
Adhesions 1 94.08 High High
Alzheimer's Dementia 2 92.12 High High
Drug Induced Neurotoxicity 7 91.56 High High
Overactive Bladder 3 91.20 High High
Poisoning 5 90.72 High High
Nerve Degeneration 1 89.16 High High
Neurodegenerative Disease 2 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the levels of mRNA expression of NF-H, NF-M, and NF-L genes were elevated consistently in CS(2)-treated groups.
Gene_expression (expression) of NF-M
1) Confidence 0.52 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 17120161 Disease Relevance 0.09 Pain Relevance 0.08
The contents of six cytoskeletal proteins (NF-L, NF-M, NF-H, alpha-tubulin, beta-tubulin, and beta-actin) in both fractions were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting.
Spec (determined) Gene_expression (contents) of NF-M
2) Confidence 0.48 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 17043767 Disease Relevance 0.35 Pain Relevance 0.18
For that, we investigated the changes of CaM, CaMKII, protein kinase C (PKC) and polymerization ratios (PRs) of NF-L, NF-M and NF-H in cerebral cortex (CC, including total cortex and some gray), spinal cord (SC) and sciatic nerve (SN) of rats treated with HD at a dosage of 1.75 or 3.50 mmol/kg for 8 weeks (five times per week).
Spec (investigated) Gene_expression (changes) of NF-M in spinal cord associated with kinase c, sciatic nerve, cerebral cortex and spinal cord
3) Confidence 0.44 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18582483 Disease Relevance 0.19 Pain Relevance 0.77
Then, the contents of six cytoskeletal protein (NF-L, NF-M, NF-H, alpha-tubulin, beta-tubulin, and beta-actin) in both fractions were determined by immunoblotting.
Spec (determined) Gene_expression (contents) of NF-M
4) Confidence 0.39 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16474999 Disease Relevance 0.08 Pain Relevance 0.12
Compared with the control, the levels of NF-L, NF-M, NF-H, beta-actin, tau, MAP2 proteins decreased and the level of alpha-tubulin increased in high ACR group, the levels of alpha-tubulin, beta-tubulin and MAP2 increased in low ACR group.
Gene_expression (levels) of NF-M
5) Confidence 0.38 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16845587 Disease Relevance 0.24 Pain Relevance 0.07
Rats were all killed after 8 weeks to evaluate the levels of neurofilament(NF)-L, NF-M, NF-H, beta-actin, alpha-tubulin, beta-tubulin, tau, MAP2 proteins in plasma using both SDS-PAGE and western blotting.
Gene_expression (levels) of NF-M in plasma
6) Confidence 0.38 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16845587 Disease Relevance 0.24 Pain Relevance 0.06
Mature neurons, whose perikaryons and axons are entirely located within the central nervous system, express the low molecular mass neurofilament protein and not the 57,000 mol. wt intermediate filament protein called "peripherin".
Neg (not) Gene_expression (express) of neurofilament protein in perikaryons associated with central nervous system
7) Confidence 0.36 Published 1993 Journal Neuroscience Section Abstract Doc Link 8450965 Disease Relevance 0 Pain Relevance 0.36
The relative levels of six cytoskeletal proteins (NF-L, NF-M, NF-H, alpha-tubulin, beta-tubulin, and beta-actin) in both fractions were determined by immunoblotting.
Spec (determined) Gene_expression (levels) of NF-M
8) Confidence 0.31 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17447142 Disease Relevance 0.16 Pain Relevance 0.11
RESULTS: The flinching and licking time of group NeF was shorter than that of group F, and the Fos expression of group NeF was weaker than that of group F.
Gene_expression (expression) of NeF
9) Confidence 0.20 Published 2003 Journal Sichuan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 14619585 Disease Relevance 0 Pain Relevance 0
Recent electrophysiologic and histologic studies in rats have revealed that chronic SCI induces various phenotypic changes in bladder afferent neurons such as: (1) somal hypertrophy along with increased expression of neurofilament protein; and (2) increased excitability due to the plasticity of Na+ and K+ ion channels.
Gene_expression (expression) of neurofilament protein in bladder associated with hypertrophy and frailty
10) Confidence 0.19 Published 1999 Journal Prog. Neurobiol. Section Abstract Doc Link 10221783 Disease Relevance 1.21 Pain Relevance 0.29
Levels of high molecular weight neurofilament protein and activity of the lysosomal enzyme arylsulphatase were measured as internal controls and indicators of neuronal damage.
Gene_expression (Levels) of neurofilament protein in internal
11) Confidence 0.07 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8047297 Disease Relevance 0.26 Pain Relevance 0.21

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